Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nora Lam"'
Autor:
Michelle Miron, Wenzhao Meng, Aaron M. Rosenfeld, Shirit Dvorkin, Maya Meimei Li Poon, Nora Lam, Brahma V. Kumar, Yoram Louzoun, Eline T. Luning Prak, Donna L. Farber
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circula
Externí odkaz:
https://doaj.org/article/c9735e3dd8794a808679dc6e6b7b0c8f
Autor:
Margot Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Zharko Daniloski, John A Morris, Veit Hornung, Johannes Schumacher, Tuuli Lappalainen
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009684 (2021)
Functional mechanisms remain unknown for most genetic loci associated to complex human traits and diseases. In this study, we first mapped trans-eQTLs in a data set of primary monocytes stimulated with LPS, and discovered that a risk variant for auto
Externí odkaz:
https://doaj.org/article/a9681609f382419c9c62501e1adfff8e
Autor:
Maya M. L. Poon, Daniel P. Caron, Zicheng Wang, Steven B. Wells, David Chen, Wenzhao Meng, Peter A. Szabo, Nora Lam, Masaru Kubota, Rei Matsumoto, Adeeb Rahman, Eline T. Luning Prak, Yufeng Shen, Peter A. Sims, Donna L. Farber
Publikováno v:
Nature Immunology. 24:309-319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033281850135482864079a3a9e7c0209
https://doi.org/10.1038/s41590-022-01395-9
https://doi.org/10.1038/s41590-022-01395-9
Autor:
Basak B. Ural, Daniel P. Caron, Pranay Dogra, Steven B. Wells, Peter A. Szabo, Tomer Granot, Takashi Senda, Maya M. L. Poon, Nora Lam, Puspa Thapa, Yoon Seung Lee, Masaru Kubota, Rei Matsumoto, Donna L. Farber
Publikováno v:
Nat Med
The elderly are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a8c1b2a86e80da630ee006b53c4b8b
https://doi.org/10.1038/s41591-022-02073-x
https://doi.org/10.1038/s41591-022-02073-x
Autor:
Kathryn M. Hastie, Zeli Zhang, Maya M.L. Poon, Donna L. Farber, Erica Ollmann Saphire, Rei Matsumoto, Steven B. Wells, Thomas J. Connors, Marissa C. Bradley, Daniela Weiskopf, Basak Burcu Ural, Yu Kato, Alba Grifoni, Maigan A. Brusko, Alessandro Sette, Peter A. Szabo, Todd M. Brusko, Nora Lam, Yoon S. Lee, Masaru Kubota, Joshua I. Gray, Shane Crotty, Ksenia Rybkina, Nathaniel I. Bloom, Pranay Dogra
Publikováno v:
Sci Immunol
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ad8624093a3b28e6ebfa004280f20a
https://doi.org/10.1126/sciimmunol.abl9105
https://doi.org/10.1126/sciimmunol.abl9105
This protocol describes a method for the isolation of pan-lymphocytes, pan-myeloid cells, and progenitors from human lymph node tissue. By providing defined media formulations, volumes at each step, and a defined dilution factor for density centrifug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95727ea6a365fa5e87a3c955c7cfad7b
https://doi.org/10.17504/protocols.io.bwsapeae
https://doi.org/10.17504/protocols.io.bwsapeae
This protocol describes a method for the isolation of pan-lymphocytes and pan-myeloid cells from human whole blood. By providing defined media formulations, volumes at each step, and a defined dilution factor for density centrifugation, it yields con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98a6ae565b8b66a30926b21e05a3e33
https://doi.org/10.17504/protocols.io.bwr6pd9e
https://doi.org/10.17504/protocols.io.bwr6pd9e
This protocol describes a method for the isolation of pan-lymphocytes, pan-myeloid cells, and progenitors from human bone marrow aspirate. By providing defined media formulations, volumes at each step, and a defined dilution factor for density centri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364038a8000c46d4569f25ab935e4fac
https://doi.org/10.17504/protocols.io.bwrupd6w
https://doi.org/10.17504/protocols.io.bwrupd6w
Autor:
Lingyin Li, Bin Hu, Wenqiang Cao, Simon Lambert, Nora Lam, Sadhana Gaddam, Donna L. Farber, Fengqin Fang, Yong Wang, Jörg J. Goronzy, Cornelia M. Weyand, Chulwoo Kim, Huimin Zhang, Wenliang Zhu
Memory T cells exhibit considerable diversity that determines their ability to be protective and their durability. Here, we examined whether changes in T cell heterogeneity contribute to the age-associated failure of immune memory. By screening for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a108d4145656174da771b4479cd9c68e
https://doi.org/10.1101/2021.05.29.446296
https://doi.org/10.1101/2021.05.29.446296
Autor:
Donna L. Farber, Thomas J. Connors, Eline T. Luning Prak, Yufeng Shen, Peter A. Szabo, Maya M.L. Poon, Steven B. Wells, Todd M. Brusko, Daniela Weiskopf, Alba Grifoni, Wenzhao Meng, Rei Matsumoto, Pranay Dogra, Nora Lam, Eve Byington, Basak Burcu Ural, Masaru Kubota, Aaron M. Rosenfeld, Maigan A. Brusko, Alessandro Sette, Peter A. Sims
Publikováno v:
Cell reports
SUMMARY The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that shape maintenance and function of anti-viral T cell immunity in the body by compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b073e635d4e1ec6490abaef309f149
https://doi.org/10.2139/ssrn.3881346
https://doi.org/10.2139/ssrn.3881346