Výsledky vyhledávání - "Nora Francini"

Akademický článek

Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics

Externí odkaz: https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947

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Akademický článek

Polymers for binding of the gram-positive oral pathogen Streptococcus mutans.

Autor: Eugene P Magennis, Nora Francini, Francesca Mastrotto, Rosa Catania, Martin Redhead, Francisco Fernandez-Trillo, David Bradshaw, David Churchley, Klaus Winzer, Cameron Alexander, Giuseppe Mantovani

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180087 (2017)

Streptococcus mutans is the most significant pathogenic bacterium implicated in the formation of dental caries and, both directly and indirectly, has been associated with severe conditions such as multiple sclerosis, cerebrovascular and peripheral ar

Externí odkaz: https://doaj.org/article/1fb1022d9ba94add968914f9e69db764

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A Reactive Oxygen Species-Scavenging ‘Stealth’ Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors

Autor: Richard d’Arcy, Farah El Mohtadi, Nora Francini, Carlisle R. DeJulius, Hyunmoon Back, Arianna Gennari, Mike Geven, Maria Lopez-Cavestany, Zulfiye Yesim Turhan, Fang Yu, Jong Bong Lee, Michael R. King, Leonid Kagan, Craig L. Duvall, Nicola Tirelli

Publikováno v: D'Arcy, R, El Mohtadi, F, Francini, N, Dejulius, C R, Back, H, Gennari, A, Geven, M, Lopez-Cavestany, M, Turhan, Z Y, Yu, F, Lee, J B, King, M R, Kagan, L, Duvall, C L & Tirelli, N 2022, ' A Reactive Oxygen Species-Scavenging Stealth' Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors ', Journal of the American Chemical Society, vol. 144, no. 46, pp. 21304-21317 . https://doi.org/10.1021/jacs.2c09232

This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d084ca9f80077be1bc82ced68025a47
https://doi.org/10.1021/jacs.2c09232

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Versatile Preparation of Branched Polylactides by Low-Temperature, Organocatalytic Ring-Opening Polymerization in N-Methylpyrrolidone and Their Surface Degradation Behavior

Autor: Athanassia Athanassiou, Arianna Gennari, Giulia Scoponi, Nora Francini, Richard d'Arcy, Veronica Paradiso, Nicola Tirelli, Carmine Capacchione, Roberto Donno

Publikováno v: Macromolecules

We describe how the organocatalytic, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-based lactide ring-opening polymerization can be effectively performed in a very polar solvent, N-methylpyrrolidone (NMP). Due to a low ceiling temperature, this “living�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d85bb9619dc65af02d6cf2515a12612
https://doi.org/10.1021/acs.macromol.1c01503

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Abstract 2706: Therapeutic silencing of Rictor using siRNA nanoparticles to selectively block mTORC2 signaling in triple negative breast cancer

Autor: Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Nora Francini, Richard A. d'Arcy, Rebecca S. Cook, Craig L. Duvall

Publikováno v: Cancer Research. 83:2706-2706

Triple negative breast cancers (TNBCs) are aggressive malignancies with a high rate of recurrence even after neoadjuvant chemotherapy (NAC) and resection. Nearly 50% of NAC-treated TNBC patients harboring residual disease display mutations in the pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48a889f88ef3773a5e347214b27650fd
https://doi.org/10.1158/1538-7445.am2023-2706

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Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

Autor: Athanassia Athanassiou, Iosifina Gounaki, Arianna Gennari, Rosalia Bertorelli, Danae Venieri, Giulia Suarato, Nora Francini, Despoina Kossyvaki, Nicola Tirelli, Maria Summa, Evie L. Papadopoulou

Publikováno v: Materials Advances. 1:1805-1816

Novel electrospun fibrous biocomposites have been fabricated, based on two naturally derived materials, namely wool keratin and cinnamon essential oil, and their efficacy for the treatment of skin burns caused by UVB exposure is demonstrated. The cin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cac01612b4a234a4f675ee39d88026a2
https://doi.org/10.1039/d0ma00416b

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