Výsledky vyhledávání - "Nora E. Joseph"

Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications

The oligometastasis hypothesis suggests a spectrum of metastatic virulence where some metastases are limited in extent and curable with focal therapies. A subset of patients with metastatic colorectal cancer achieves prolonged survival after resectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ef25ca0c1612dc2b4cbbedc27b2acc
http://link.springer.com/article/10.1038/s41467-018-04278-6

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Pathologic Response to Primary Systemic Therapy With FOLFIRINOX in Patients With Resectable Pancreatic Cancer

Autor: Nora E Joseph, Robert D. Marsh, Ariel Polish

Publikováno v: American journal of clinical oncology. 42(10)

Background Primary systemic therapy in resectable pancreatic cancer is currently under investigation. FOLFIRINOX has been shown to be effective in both the adjuvant and metastatic settings and is increasingly being used on and off study in the neoadj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a467a8d51203c295ec7d38ca4ecaf
https://pubmed.ncbi.nlm.nih.gov/31569128

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Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

Autor: Anna P. Southworth, Gregory J. Baker, Jerrold R. Turner, Karen L. Edelblum, Wangsun Choi, Ma. Lora Drizella M. Ong, Gurminder Singh, Alicia M. Worthylake, Nora E. Joseph, Peter A. Savage, Sam C. Nalle, Li Zuo, Mario C. Manresa

Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation (HSCT) that affects multiple organs. GVHD-associated intestinal damage can be separated into two distinct phases, initiation and propagation, which correspo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1e608626408068b7e93007485e1ceb
https://europepmc.org/articles/PMC6355225/

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Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization

Autor: Qingfeng Zhu, Gianfranco Alpini, Bin Guan, Nailing Zhang, Douglas N. Robinson, Ying Liu, Yixin Ren, Tianzhi Luo, Nora E. Joseph, Duojia Pan, Alexandra Surcel, Tian Li Wang, Robert A. Anders, Haibo Bai, Nan Wu

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G396-G411

The Hippo pathway effector Yes-associated protein (YAP) regulates liver size by promoting cell proliferation and inhibiting apoptosis. However, recent in vivo studies suggest that YAP has important cellular functions other than controlling proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbeca6a0c2c947b95c4e48494972c8a
https://doi.org/10.1152/ajpgi.00027.2016

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Insufficient Autoantigen Presentation and Failure of Tolerance in a Mouse Model of Rheumatoid Arthritis

Autor: Nora E. Joseph, Jason Perera, Yuzhen Zhou, Xiao Liu, Jerrold R. Turner, Liping Meng, Haochu Huang

Publikováno v: Arthritis & Rheumatism. 65:2847-2856

Objective In the K/BxN mouse model of rheumatoid arthritis, T cells reactive for the self antigen glucose-6-phosphate isomerase (GPI) escape negative selection even though GPI expression is ubiquitous. We sought to determine whether insufficient GPI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::933cbe45ff684666103e8f619bd30f35
https://doi.org/10.1002/art.38085

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ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture

Autor: Mary M. Buschmann, Yitang Wang, Aaron Buckley, Matthew A. Odenwald, Jeffrey D. Hildebrand, Nora E. Joseph, Alan S. Fanning, Roman Pavlyuk, Nitesh Shashikanth, Wangsun Choi, Jerrold R. Turner, Michael H. Warren, Ben Margolis

Publikováno v: Journal of cell science. 130(1)

Epithelia within tubular organs form and expand lumens. Failure of these processes can result in serious developmental anomalies. Although tight junction assembly is crucial to epithelial polarization, the contribution of specific tight junction prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b344d78182a5f7ace6be985836dade
https://pubmed.ncbi.nlm.nih.gov/27802160

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USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst

Autor: Julia A. Bridge, Andrew E. Rosenberg, Jonathan A. Fletcher, Bae Li Hsi, Antonio R. Perez-Atayde, Andre M. Oliveira, Paola Dal Cin, Stanislawa Weremowicz, Nora E. Joseph

Publikováno v: Cancer Research. 64:1920-1923

Aneurysmal bone cyst (ABC) is a locally aggressive osseous lesion that typically occurs during the first two decades of life. ABC was regarded historically as a nonneoplastic process, but recent cytogenetic data have shown clonal rearrangements of ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f083480bcbafb325c5a43e3f4bd4fc
https://doi.org/10.1158/0008-5472.can-03-2827

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Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease

Autor: Eric D. Mortenson, Karen L. Edelblum, Galina Khramtsova, H. Aimee Kwak, Jerrold R. Turner, Nora E. Joseph, Peter A. Savage, Gurminder Singh, Sam C. Nalle

Publikováno v: Science translational medicine. 6(243)

Previous studies have shown a correlation between pretransplant conditioning intensity, intestinal barrier loss, and graft-versus-host disease (GVHD) severity. However, because irradiation and other forms of pretransplant conditioning have pleiotropi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a72d2a2b37849ccd0a6748533df9fcc
https://pubmed.ncbi.nlm.nih.gov/24990882

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