Systemic and Renal Dynamics of Free Sulfhydryl Groups during Living Donor Kidney Transplantation

Autor: Nora A. Spraakman, Annemieke M. Coester, Arno R. Bourgonje, Vincent B. Nieuwenhuijs, Jan-Stephan F. Sanders, Henri G. D. Leuvenink, Harry van Goor, Gertrude J. Nieuwenhuijs-Moeke

Publikováno v: International Journal of Molecular Sciences, 23(17):9789. MDPI AG
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9789

During ischemia–reperfusion injury (IRI), reactive oxygen species are produced that can be scavenged by free sulfhydryl groups (R-SH, free thiols). In this study, we hypothesized that R-SH levels decrease as a consequence of renal IRI and that R-SH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699ce1e7a90063d56ca5f2644bd88c50
https://research.rug.nl/en/publications/283a63a1-a84d-4417-b4d4-ff65ba4d6667

Proteomic analysis of machine perfusion solution from brain dead donor kidneys reveals that elevated complement, cytoskeleton and lipid metabolism proteins are associated with 1-year outcome

Autor: Honglei Huang, Bas W M van Balkom, Adam M. Thorne, Rutger J. Ploeg, Sarah Bonham, Henri G. D. Leuvenink, L Leonie van Leeuwen, Nora A Spraakman, Aukje Brat, Benedikt M. Kessler

Publikováno v: Transplant International, 34(9), 1618-1629. Wiley

Assessment of donor kidney quality is based on clinical scores or requires biopsies for histological assessment. Noninvasive strategies to identify and predict graft outcome at an early stage are, therefore, needed. We evaluated the perfusate of dona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffff8f2a7d4481fb9e602ac32825243
https://pubmed.ncbi.nlm.nih.gov/34448265