Supplementary Figures S1 - S6, Tables S1 - S2 from First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

Autor: Timothy Guzi, Nancy E. Kohl, Christoph Lengauer, Christopher Winter, Adam Shutes, Natasja Brooijmans, Brian Hodous, Joseph L. Kim, Neil Bifulco, Nicolas Stransky, Weifan Weng, Nooreen Rubin, Michael Sheets, Chandra Miduturu, Margit Hagel

Supplementary Figure S1. Potency against FGFR family and kinome selectivity. Supplementary Figure S2. Kinases with a cysteine at the equivalent position to Cys552 in FGFR4. Supplementary Figure S3. MALDI Mass Spectrometry of FGFR4. Supplementary Figu

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https://doi.org/10.1158/2159-8290.22530420

Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma

Autor: Oleg Schmidt-Kittler, Michael Sheets, Yoon-Koo Kang, Chandrasekhar V. Miduturu, Richard D. Kim, Andy Boral, Joseph L. Kim, Nooreen Rubin, Neil Bifulco, Emily Rozsahegyi, Cori Ann Sherwin, Megan A. Hatlen, Natasja Brooijmans, Marion Dorsch, Hongliang Shi, Beni B. Wolf, Klaus P. Hoeflich, Christoph Lengauer, Timothy J. Guzi

Publikováno v: Cancer Discovery. 9:1686-1695

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide with no clinically confirmed oncogenic driver. Although preclinical studies implicate the FGF19 receptor FGFR4 in hepatocarcinogenesis, the dependence of human cancer on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb336958095dcb0a493f3604a752c01
https://doi.org/10.1158/2159-8290.cd-19-0367

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

Autor: Lily I. Pao, Quentin J. Baca, Clifford A. Lowell, Kenneth D. Swanson, David E. Golan, Nooreen Rubin, Takashi Matozaki, Benjamin G. Neel, Francis J. Alenghat

Publikováno v: Journal of cell science, vol 125, iss Pt 22
Alenghat, FJ; Baca, QJ; Rubin, NT; Pao, LI; Matozaki, T; Lowell, CA; et al.(2012). Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement. Journal of Cell Science, 125(22), 5535-5545. doi: 10.1242/jcs.111260. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1xx8h9bk

Macrophages migrate to sites of insult during normal inflammatory responses. Integrins guide such migration, but the transmission of signals from integrins into the requisite cytoskeletal changes is poorly understood. We have discovered that the hema

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https://escholarship.org/uc/item/1xx8h9bk