Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Noora, Puhakka"'
Autor:
Noora Puhakka, Shalini Das Gupta, Sara Leskinen, Mette Heiskanen, Janika N?ttinen, Ulla Aapola, Hannu Uusitalo, Asla Pitk?nen
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 359-366 (2023)
Traumatic brain injury (TBI) damages the glymphatic-lymphatic system. We hypothesized that brain injury associated with trauma results in the enrichment of brain-relevant proteins in deep cervical lymph nodes (DCLNs), the end station of meningeal lym
Externí odkaz:
https://doaj.org/article/bb3e46d14d1d4ef3a2c4d7681f7e74e2
Autor:
Natallie Kajevu, Anssi Lipponen, Pedro Andrade, Ivette Bañuelos, Noora Puhakka, Elina Hämäläinen, Teemu Natunen, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14049 (2023)
We tested a hypothesis that in silico-discovered compounds targeting traumatic brain injury (TBI)-induced transcriptomics dysregulations will mitigate TBI-induced molecular pathology and augment the effect of co-administered antiseizure treatment, th
Externí odkaz:
https://doaj.org/article/1f3bc2149fe249bdb536c8bf79bb03a8
Autor:
Anssi Lipponen, Natallie Kajevu, Teemu Natunen, Robert Ciszek, Noora Puhakka, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4116 (2023)
Analysis platforms to predict drug-induced seizure liability at an early phase of drug development would improve safety and reduce attrition and the high cost of drug development. We hypothesized that a drug-induced in vitro transcriptomics signature
Externí odkaz:
https://doaj.org/article/46ba25784dc24975adec02344f432ac5
Autor:
Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2823 (2023)
Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies. The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to the development of anti-epileptogenic treatments. Previous stud
Externí odkaz:
https://doaj.org/article/7cb1f8cc01744e48a0dd32c913752564
Autor:
Mette Heiskanen, Olli Jääskeläinen, Eppu Manninen, Shalini Das Gupta, Pedro Andrade, Robert Ciszek, Olli Gröhn, Sanna-Kaisa Herukka, Noora Puhakka, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15208 (2022)
Plasma neurofilament light chain (NF-L) levels were assessed as a diagnostic biomarker for traumatic brain injury (TBI) and as a prognostic biomarker for somatomotor recovery, cognitive decline, and epileptogenesis. Rats with severe TBI induced by la
Externí odkaz:
https://doaj.org/article/49991ee49d01431aad7523ce87096785
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 42-58 (2019)
A biomarker is a characteristic that is measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecular, histologic,
Externí odkaz:
https://doaj.org/article/799f11f55bff4bdd8dfc4a23d098fd96
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 136 (2022)
Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injur
Externí odkaz:
https://doaj.org/article/30ccca4e4d274c79ac4586cd391d04b9
Autor:
Jenni Karttunen, Mette Heiskanen, Vicente Navarro-Ferrandis, Shalini Das Gupta, Anssi Lipponen, Noora Puhakka, Kirsi Rilla, Arto Koistinen, Asla Pitkänen
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
The microRNA (miRNA) cargo contained in plasma extracellular vesicles (EVs) offers a relatively little explored source of biomarkers for brain diseases that can be obtained noninvasively. Methods to isolate EVs from plasma, however, are still being d
Externí odkaz:
https://doaj.org/article/714647fa127c45f289b2991561f1709d
Autor:
Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan KN, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen, Asla Pitkänen
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies in clinical use that favorably
Externí odkaz:
https://doaj.org/article/70e583e43a604244a0470a3b1f15a4a0
Autor:
Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara, Anssi Lipponen, Silvia Balosso, Elina Hämäläinen, Shalini Das Gupta, Noora Puhakka, Teemu Natunen, Teresa Ravizza, Annamaria Vezzani, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10555 (2021)
We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug N-acetylcysteine (NAC) or sulforaphane (SFN) as monotherapies or duotherapy in vitro in neuron-BV2 microglial co-cultures and validated the
Externí odkaz:
https://doaj.org/article/b998370c5ed947969d9f9c88922b1f47