Epilepsy biomarkers – Toward etiology and pathology specificity

Autor: Asla Pitkänen, Xavier Ekolle Ndode-Ekane, Niina Lapinlampi, Noora Puhakka

Publikováno v: Neurobiology of Disease, Vol 123, Iss , Pp 42-58 (2019)

A biomarker is a characteristic that is measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecular, histologic,

Externí odkaz: https://doaj.org/article/799f11f55bff4bdd8dfc4a23d098fd96

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Autor: Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan KN, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen, Asla Pitkänen

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)

Abstract Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies in clinical use that favorably

Externí odkaz: https://doaj.org/article/70e583e43a604244a0470a3b1f15a4a0

Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury-The EPITARGET Cohort

Autor: Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkänen

Publikováno v: International Journal of Molecular Sciences, 24(3):2823. Multidisciplinary Digital Publishing Institute (MDPI)
Heiskanen, M, Das Gupta, S, Mills, J D, van Vliet, E A, Manninen, E, Ciszek, R, Andrade, P, Puhakka, N, Aronica, E & Pitkänen, A 2023, ' Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort ', International Journal of Molecular Sciences, vol. 24, no. 3, 2823 . https://doi.org/10.3390/ijms24032823
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2823
International journal of molecular sciences, 24(3):2823. Multidisciplinary Digital Publishing Institute (MDPI)

Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies. The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to the development of anti-epileptogenic treatments. Previous stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632054b79b8b7d71b1e6ee471297b72e
https://doi.org/10.3390/ijms24032823

Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury.

Autor: Noora Puhakka, Anna Maria Bot, Niina Vuokila, Konrad Jozef Debski, Katarzyna Lukasiuk, Asla Pitkänen

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0172521 (2017)

Traumatic brain injury (TBI) can result in several dentate gyrus-regulated disabilities. Almost nothing is known about the chronic molecular changes after TBI, and their potential as treatment targets. We hypothesized that chronic transcriptional alt

Externí odkaz: https://doaj.org/article/9bb1c9c2c34c4752abc017c797d14d0d

Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology

Autor: Pitkänen, Noora Puhakka, Shalini Das Gupta, Niina Vuokila, Asla

Publikováno v: Biomedicines; Volume 10; Issue 1; Pages: 136

Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::440f52c12e6806a915193a9eb3b1ad6b