Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Noor A. Lokman"'
Autor:
Riya Khetan, Preethi Eldi, Noor A. Lokman, Carmela Ricciardelli, Martin K. Oehler, Anton Blencowe, Sanjay Garg, Katherine Pillman, Hugo Albrecht
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract Genetic heterogeneity in ovarian cancer indicates the need for personalised treatment approaches. Currently, very few G-protein coupled receptors (GPCRs) have been investigated for active targeting with nanomedicines such as antibody-conjuga
Externí odkaz:
https://doaj.org/article/c01647f0a122462aaa86f0867aefdd8e
Autor:
Dilys Leung, Zoe K. Price, Noor A. Lokman, Wanqi Wang, Lizamarie Goonetilleke, Elif Kadife, Martin K. Oehler, Carmela Ricciardelli, George Kannourakis, Nuzhat Ahmed
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-23 (2022)
Abstract Background Epithelial ovarian cancer is the most lethal gynaecological cancer worldwide. Chemotherapy resistance represents a significant clinical challenge and is the main reason for poor ovarian cancer prognosis. We identified novel expres
Externí odkaz:
https://doaj.org/article/0bf982e54f6942ba87713c8c2e280ab1
Autor:
Zoe K. Price, Noor A. Lokman, Masato Yoshihara, Hiroaki Kajiyama, Martin K. Oehler, Carmela Ricciardelli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 696 (2022)
Disabled-2 (DAB2), a key adaptor protein in clathrin mediated endocytosis, is implicated in the regulation of key signalling pathways involved in homeostasis, cell positioning and epithelial to mesenchymal transition (EMT). It was initially identifie
Externí odkaz:
https://doaj.org/article/9f76f1e330f54edd9d82851654466255
Autor:
Muhammed H. Rahaman, Frankie Lam, Longjin Zhong, Theodosia Teo, Julian Adams, Mingfeng Yu, Robert W. Milne, Chris Pepper, Noor A. Lokman, Carmela Ricciardelli, Martin K. Oehler, Shudong Wang
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2178-2193 (2019)
Colorectal cancer (CRC) remains one of the most lethal human malignancies, and pursuit of new therapeutic targets for treatment has been a major research focus. Cyclin‐dependent kinase 9 (CDK9), which plays a crucial role in transcription, has emer
Externí odkaz:
https://doaj.org/article/cbaa876250d345bd9ed140b6e56eb1f2
Autor:
Noor A. Lokman, Rachel Ho, Kavyadharshini Gunasegaran, Wendy M. Bonner, Martin K. Oehler, Carmela Ricciardelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-12 (2019)
Abstract Background Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating
Externí odkaz:
https://doaj.org/article/655d7285af304e999c05fead853cdf0d
Autor:
Florian Weiland, Noor A. Lokman, Manuela Klingler-Hoffmann, Thomas Jobling, Andrew N. Stephens, Karin Sundfeldt, Peter Hoffmann, Martin K. Oehler
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ovarian cancer is the most lethal gynecologic malignancy. Early detection would improve survival, but an effective diagnostic test does not exist. Novel biomarkers for early ovarian cancer diagnosis are therefore warranted. We performed intraoperativ
Externí odkaz:
https://doaj.org/article/e688cee0f3b749709580f0d24b9e20f1
Autor:
Kathryn A. Palasis, Noor A. Lokman, Bryden C. Quirk, Alaknanda Adwal, Loretta Scolaro, Weikun Huang, Carmela Ricciardelli, Martin K. Oehler, Robert A. McLaughlin, Andrew D. Abell
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10844 (2021)
Local activation of an anti-cancer drug when and where needed can improve selectivity and reduce undesirable side effects. Photoswitchable drugs can be selectively switched between active and inactive states by illumination with light; however, the c
Externí odkaz:
https://doaj.org/article/38ae3d5432854cdaa9186ac918371334
Autor:
Noor A. Lokman, Carmela Ricciardelli, Andrew N. Stephens, Thomas W. Jobling, Peter Hoffmann, Martin K. Oehler
Publikováno v:
Diagnostics, Vol 11, Iss 1, p 69 (2021)
Ovarian cancer (OC) is commonly diagnosed at advanced stage when prognosis is poor. Consequently, there is an urgent clinical need to identify novel biomarkers for early detection to improve survival. We examined the diagnostic value of the calcium p
Externí odkaz:
https://doaj.org/article/24376952bc5b42eca92c86e8bddc56df
Autor:
Janelle Cheung, Noor A. Lokman, Riya D. Abraham, Anne M. Macpherson, Eunice Lee, Frank Grutzner, Nicolae Ghinea, Martin K. Oehler, Carmela Ricciardelli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 71 (2020)
Follicle-stimulating hormone (FSH) and luteinising hormone (LH) play important roles in regulating cell growth and proliferation in the ovary. However, few studies have explored the expression of FSH and LH receptors (FSHR and LHCGR) in ovarian cance
Externí odkaz:
https://doaj.org/article/4e7dc1c7f8be4ea99e59d92a77d43573
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 4122 (2018)
S100A10, which is also known as p11, is located in the plasma membrane and forms a heterotetramer with annexin A2. The heterotetramer, comprising of two subunits of annexin A2 and S100A10, activates the plasminogen activation pathway, which is involv
Externí odkaz:
https://doaj.org/article/5dae557babc04c248471cf5b1d909165