Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Noor, Gammoh"'
Autor:
Agata N. Makar, Alina Boraman, Peter Mosen, Joanne E. Simpson, Jair Marques, Tim Michelberger, Stuart Aitken, Ann P. Wheeler, Dominic Winter, Alex von Kriegsheim, Noor Gammoh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen,
Externí odkaz:
https://doaj.org/article/6883251db50c4cf790616ebe8bd9529f
Autor:
Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen, Andrew J. Finch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand a
Externí odkaz:
https://doaj.org/article/f58e694b2f6c429fb6bed6c1ae69a6f7
Autor:
María Ángeles Marqués-Torrejón, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via m
Externí odkaz:
https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae
Autor:
Joanne E. Simpson, Noor Gammoh
Publikováno v:
Open Biology, Vol 10, Iss 9 (2020)
Glioblastoma is the most common and aggressive adult brain tumour, with poor median survival and limited treatment options. Following surgical resection and chemotherapy, recurrence of the disease is inevitable. Genomic studies have identified key dr
Externí odkaz:
https://doaj.org/article/685ab3507c4342e18e26d53edbabfd00
Publikováno v:
Debnath, J, Gammoh, N & Ryan, K M 2023, ' Autophagy and autophagy-related pathways in cancer ', Nature reviews Molecular cell biology . https://doi.org/10.1038/s41580-023-00585-z
Maintenance of protein homeostasis and organelle integrity andfunction is critical for cellular homeostasis and cell viability. Autophagyis the principal mechanism that mediates the delivery of variouscellular cargoes to lysosomes for degradation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f71831141504f59a23881bb37a83b8
https://escholarship.org/uc/item/6h86s344
https://escholarship.org/uc/item/6h86s344
Publikováno v:
The FEBS Journal. 287:4806-4821
Autophagosomes are vital organelles required to facilitate the lysosomal degradation of cytoplasmic cargo, thereby playing an important role in maintaining cellular homeostasis. A number of autophagy-related (ATG) protein complexes are recruited to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f746c1c5acb372b402ee73dfb5fee0f5
https://doi.org/10.1111/febs.15334
https://doi.org/10.1111/febs.15334
Autor:
Melanie Clements, Neza Alfazema, Noor Gammoh, Charles A. C. Williams, Claudia Garcia-Diaz, Jane Fraser, Nerea Arranz-Emparan, Carla Blin, Maria Angeles Marques-Torrejon, Steven M. Pollard, Benjamin Southgate, Simona Parrinello
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Marques, M A, Williams, C, Southgate, B, Alfazema, N, Clements, M, Garcia-Diaz, C, Blin, C, Arranz Emparan, N, Fraser, J, Gammoh, N, Parrinello, S & Pollard, S M 2021, ' LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells ', Nature Communications . https://doi.org/10.1038/s41467-021-22813-w
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Marques, M A, Williams, C, Southgate, B, Alfazema, N, Clements, M, Garcia-Diaz, C, Blin, C, Arranz Emparan, N, Fraser, J, Gammoh, N, Parrinello, S & Pollard, S M 2021, ' LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells ', Nature Communications . https://doi.org/10.1038/s41467-021-22813-w
Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture and characterize in vitro primed quiescent NSCs and identify LRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44f00af03c17ccd8fd2c1c02d4205d9
http://europepmc.org/articles/PMC8110534
http://europepmc.org/articles/PMC8110534
Autor:
Noor Gammoh
Publikováno v:
Gammoh, N 2020, ' The multifaceted functions of ATG16L1 in autophagy and related processes ', Journal of Cell Science . https://doi.org/10.1242/jcs.249227
Autophagy requires the formation of membrane vesicles, known as autophagosomes, that engulf cellular cargoes and subsequently recruit lysosomal hydrolases for the degradation of their contents. A number of autophagy-related proteins act to mediate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35620e1e8e293ad0ae21380d30897271
https://www.pure.ed.ac.uk/ws/files/159754938/The_multifaceted_functions_of_ATG16L1_in_autophagy_and_related_processes.pdf
https://www.pure.ed.ac.uk/ws/files/159754938/The_multifaceted_functions_of_ATG16L1_in_autophagy_and_related_processes.pdf
Autor:
David Mellis, Andrea Martello, Domenico D'Arca, Lisa Imrie, Andrea Caporali, Noor Gammoh, John C. Dawson, Elisa Parish, Neil O. Carragher, Nicholas L. Mills, Angela Lauriola, Martina Vidmar, Mairi Brittan, Tijana Mitić
Publikováno v:
EMBO Reports
Martello, A, Lauriola, A, Mellis, D, Parish, E, Dawson, J C, Imrie, L, Vidmar, M, Gammoh, N, Mitić, T, Brittan, M, Mills, N L, Carragher, N O, D'arca, D & Caporali, A 2020, ' Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy ', EMBO Reports . https://doi.org/10.15252/embr.201948192
Martello, A, Lauriola, A, Mellis, D, Parish, E, Dawson, J C, Imrie, L, Vidmar, M, Gammoh, N, Mitić, T, Brittan, M, Mills, N L, Carragher, N O, D'arca, D & Caporali, A 2020, ' Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy ', EMBO Reports . https://doi.org/10.15252/embr.201948192
Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252268a62a4ffc2874c85e117a1d5a01
https://hdl.handle.net/11380/1201619
https://hdl.handle.net/11380/1201619