Zobrazeno 1 - 10
of 1 127
pro vyhledávání: '"Nonribosomal peptide synthetase"'
Autor:
Barbara R. Terlouw, Friederike Biermann, Sophie P. J. M. Vromans, Elham Zamani, Eric J. N. Helfrich, Marnix H. Medema
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Natural products are molecules that fulfil a range of important ecological functions. Many natural products have been exploited for pharmaceutical and agricultural applications. In contrast to many other specialised metabolites, the products
Externí odkaz:
https://doaj.org/article/05b9a26e73d14f05a536e4c5488a18c0
Autor:
Haixia Zang, Yijia Cheng, Mengjia Li, Lin Zhou, Li-Li Hong, Hai Deng, Hou-Wen Lin, Yongjun Zhou
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Natural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of bioactivities. Biosynthesis of tetramates in microorganisms is normally directed by hybrid poly
Externí odkaz:
https://doaj.org/article/3c8eb3ebe787474681008fcc9b16838c
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 445-451 (2024)
The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins. Hence, the inhibition of A-domains could
Externí odkaz:
https://doaj.org/article/fda6b33ee917401da302b4b9d9863f7f
Publikováno v:
Marine Drugs, Vol 22, Iss 8, p 349 (2024)
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The
Externí odkaz:
https://doaj.org/article/0e500052f53c48028e4fa263110e0ec2
Autor:
Xiaolin Zou, Zhen Hui, Robert A. Shepherd, Shuaiqiang Zhao, Yanfei Wu, Zhuanglin Shen, Cuiping Pang, Shipeng Zhou, Zehai Yu, Jiahai Zhou, Bradley S. Moore, Laura M. Sanchez, Xiaoyu Tang
Publikováno v:
Advanced Science, Vol 11, Iss 4, Pp n/a-n/a (2024)
Abstract The assembly line biosynthesis of the powerful anticancer‐antiviral didemnin cyclic peptides is proposed to follow a prodrug release mechanism in Tristella bacteria. This strategy commences with the formation of N‐terminal prodrug scaffo
Externí odkaz:
https://doaj.org/article/ca18ab80f7494d1797d491c5704c17ef
Publikováno v:
Fungal Biology and Biotechnology, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract Background Secondary metabolites (SMs) from mushroom-forming fungi (Basidiomycota) and early diverging fungi (EDF) such as Mucoromycota are scarcely investigated. In many cases, production of SMs is induced by unknown stress factors or is ac
Externí odkaz:
https://doaj.org/article/1aa28ef0db804d1fa2968ab6b6bedeba
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Publikováno v:
Fungal Biology and Biotechnology, Vol 9, Iss 1, Pp 1-20 (2022)
Abstract The Diels–Alder (DA) reaction refers to a [4 + 2] cycloaddition reaction that falls under the category of pericyclic reactions. It is a reaction that allows regio- and stereo-selective construction of two carbon–carbon bonds simultaneous
Externí odkaz:
https://doaj.org/article/db512057c3ea4e2786fb824747526a72
Akademický článek
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