Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies

Autor: João B. Calixto, S.K. Oliveira, J.M. Siqueira, Juliana Cavalli, C.S. Freitas, E.L. Andrade, Allisson Freire Bento, R.C. Schwanke, Rodrigo Marcon

Publikováno v: Brazilian Journal of Medical and Biological Research, Volume: 49, Issue: 11, Article number: e5644, Published: 24 OCT 2016
Brazilian Journal of Medical and Biological Research, Vol 49, Iss 11
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.49 n.11 2016
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 49, Iss 11 (2016)

This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04259ca62a4817b4f7bc04fe56663b28
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100301&lng=en&tlng=en

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