Zobrazeno 1 - 10
of 1 769
pro vyhledávání: '"Non responders"'
Autor:
Jarosław Domaradzki, Dawid Koźlenia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract This study aimed to investigate cardiovascular and cardiorespiratory adaptations to exercise intervention among participants who showed higher (responders–Rs BFP) and lower (non-responders–NRs BFP) levels of body fat percentage (BFP) res
Externí odkaz:
https://doaj.org/article/bdf02dd6d3f14e6d8cf18c5eb6bd889b
Autor:
Johanne Dam Lyhne, Allan ‘Ben’ Smith, Lars Henrik Jensen, Torben Frøstrup Hansen, Lisbeth Frostholm, Signe Timm
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Patient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and generalizability of findings by introducing potential bias. This study aims to provide insight in
Externí odkaz:
https://doaj.org/article/b7a146b1928f4569b1f0dfe0298ddb4f
Autor:
Esperanza Muñoz-Muela, María Trujillo-Rodríguez, Ana Serna-Gallego, Abraham Saborido-Alconchel, Carmen Gasca-Capote, Ana Álvarez-Ríos, Ezequiel Ruiz-Mateos, Dmitri Sviridov, Andrew J. Murphy, Man K.S. Lee, Luis F. López-Cortés, Alicia Gutiérrez-Valencia
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105338- (2024)
Summary: Background: Among people living with HIV-1 (PHIV), immunological non-responders (INR) experience incomplete immune recovery despite suppressive antiretroviral treatment (ART), facing more severe non-AIDS events than immunological responders
Externí odkaz:
https://doaj.org/article/47ad10b8ca9a4c4b83f25cd317d658ff
Autor:
Xiuhan Yang, Cheng Zhen, Huihuang Huang, Yanmei Jiao, Xing Fan, Chao Zhang, Jinwen Song, Songshan Wang, Chunbao Zhou, XinXin Yang, Jinhong Yuan, Jiyuan Zhang, Ruonan Xu, Fu-Sheng Wang
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Increased CD4+GNLY+ T cells have been confirmed to be inversely associated with CD4+ T cell count in immunological non-responders (INRs), however, the underlying mechanisms are unknown. This study aimed to elucidate the characteristics of CD4+GNLY+ T
Externí odkaz:
https://doaj.org/article/8b456b83ac4e433d8662e830410734f1
Autor:
Leticia Szadai, Aron Bartha, Indira Pla Parada, Alexandra I.T. Lakatos, Dorottya M.P. Pál, Anna Sára Lengyel, Natália Pinto de Almeida, Ágnes Judit Jánosi, Fábio Nogueira, Beata Szeitz, Viktória Doma, Nicole Woldmar, Jéssica Guedes, Zsuzsanna Ujfaludi, Zoltán Gábor Pahi, Tibor Pankotai, Yonghyo Kim, Balázs Győrffy, Bo Baldetorp, Charlotte Welinder, A. Marcell Szasz, Lazaro Betancourt, Jeovanis Gil, Roger Appelqvist, Ho Jeong Kwon, Sarolta Kárpáti, Magdalena Kuras, Jimmy Rodriguez Murillo, István Balázs Németh, Johan Malm, David Fenyö, Krzysztof Pawłowski, Peter Horvatovich, Elisabet Wieslander, Lajos V. Kemény, Gilberto Domont, György Marko-Varga, Aniel Sanchez
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionWhile Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI ther
Externí odkaz:
https://doaj.org/article/fe95ef6a509c4265b300a1ff4e58f88f
Autor:
Wilhelm A. J. W. Vos, Adriana Navas, Elise M. G. Meeder, Marc J. T. Blaauw, Albert L. Groenendijk, Louise E. van Eekeren, Twan Otten, Nadira Vadaq, Vasiliki Matzaraki, Bram van Cranenbroek, Kees Brinkman, Jan van Lunzen, Leo A. B. Joosten, Mihai G. Netea, Willem L. Blok, Andre J. A. M. van der Ven, Hans J. P. M. Koenen, Janneke E. Stalenhoef
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionImmunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART). INR are at higher risk for non-HIV related morbidity
Externí odkaz:
https://doaj.org/article/fe9f62a30ced4509bab65036784e5714
Autor:
Maria Carolina Santos Guedes, Wlisses Henrique Veloso Carvalho-Silva, José Leandro Andrade-Santos, Maria Carolina Accioly Brelaz-de-Castro, Fabrício Oliveira Souto, Lílian Maria Lapa Montenegro, Rafael Lima Guimarães
Publikováno v:
Vaccines, Vol 12, Iss 6, p 612 (2024)
The mechanisms underlying unsatisfactory immune reconstitution in HIV-1 positive patients under ART have not been fully elucidated, even after years of investigation. Thus, this study aimed to assess the correlation between age and thymic production
Externí odkaz:
https://doaj.org/article/bfe134a62fdd459194df6263d2018b8b
Publikováno v:
Infection and Drug Resistance, Vol Volume 16, Pp 3871-3878 (2023)
Xuebin Tian,1,2,* Yiwen Xie,1,2,* Jingjing Chen,3,* Wanpeng Yin,1,2 Yu Long Zhao,1 Peng Yao,4 Mingqing Dong,4 Changzhong Jin,1,2 Nanping Wu1,2 1Cell Biology Research Platform, Jinan Microecological Biomedicine Shandong Laboratory, Jinan,
Externí odkaz:
https://doaj.org/article/04f487a8996240628ddd588eb6415903
Autor:
Katharina Kaltseis, Vera Filippi, Florian Frank, Christine Eckhardt, Alois Schiefecker, Gregor Broessner
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Objective Assessement of the responder and non-responder rate to consecutive monoclonal CGRP-antibody (CGRP-mAb) treatment, the presence of side effects, analysis of predictors of response and loss-of-effectiveness evaluation over time. Meth
Externí odkaz:
https://doaj.org/article/f4f5cf20e90b48aba90ff8c303226ab4
Autor:
Xiao-Yan Guo, Yun-Tian Guo, Ze-Rui Wang, Yan-Mei Jiao, Yue Hu, Li-Na Fan, Rui-Qin Cheng, Meng-Meng Qu, Chao Zhang, Jin-Wen Song, Ruo-Nan Xu, Xing Fan, Wen Xu, Ji-Yuan Zhang, Bing-Ke Bai, En-Qiang Linghu, Yao-Kai Chen, Ping Ma, Fu-Sheng Wang
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20790- (2023)
The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunologica
Externí odkaz:
https://doaj.org/article/714f65a1bd9046f296a5a998386a8594