Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response

Autor: James Cotterell, Adam C. N. Wong, Duncan T. Browman, Noman Bakhshi, Yue Qi, Man-Tat Lau, Josef M. Penninger, G. Gregory Neely, Yoann Planchenault, Yana A. Wilson, Lisa J. Oyston, Qiao-Ping Wang, Tiffany Cole, Herbert Herzog, Thang M. Khuong, Lei Zhang, Adam R. Cole, Stephen J. Simpson, Yong Qi Lin

Publikováno v: Cell Metabolism. 24:75-90

Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63bebf0e6aeaa94d3623fde72e82d553
https://doi.org/10.1016/j.cmet.2016.06.010

The transcriptional landscape of age in human peripheral blood

Autor: Russell P. Tracy, Nilesh J. Samani, Pascal P. Arp, Stefania Bandinelli, Anjali K. Henders, Karen N. Conneely, Sarah Williams-Blangero, John Hardy, Ingrid Meulenbelt, Henry Völzke, Stephen T. Turner, Astrid Suchy-Dicey, Peter M. Visscher, Yongmei Liu, Robert L. Johnson, Hans J. Grabe, Robert Walker, Dena G. Hernandez, Mike A. Nalls, Matthew P. Johnson, Katharina Schramm, Yolande F. M. Ramos, Jack W. Kent, Jingzhong Ding, Juan C. Troncoso, P. Eline Slagboom, Markus Perola, Sayuko Kobes, Michael Roden, Sharon L.R. Kardia, Lisa J. Oyston, Nicholas G. Martin, John Blangero, Mina Ryten, Quinta Helmer, Elisabeth B. Binder, Michael E. Weale, Mila Jhamai, Marjolein J. Peters, Pärt Peterson, Veryan Codd, Michael M. P. J. Verbiest, Yana A. Wilson, K. Maria Nylocks, Georg Homuth, Jennifer A. Brody, Daniel A. Enquobahrie, Allissa Dillman, Jerome I. Rotter, Joseph E. Powell, Thomas Kocher, Ronald H. Zielke, Taru Tukiainen, Daniah Trabzuni, Divya Mehta, Anna Murray, Lude Franke, Richard O'Brien, Philip L. De Jager, Torsten Klengel, David Melzer, Harald H H Göring, Holger Prokisch, George L. Sutphin, Peter J. Munson, Alan B. Zonderman, Luke C. Pilling, Sina A. Gharib, Noman Bakhshi, André G. Uitterlinden, Linda Broer, Adaikalavan Ramasamy, Qiao-Ping Wang, Elizabeth M. Kennedy, Paula Singmann, Cavin K. Ward-Caviness, Sonja Zeilinger, Joanne M. Murabito, Roby Joehanes, Jennifer A. Smith, Harm-Jan Westra, Colin Smith, Abraham Aviv, Bryan J. Traynor, Jeanine J. Houwing-Duistermaat, Thomas Illig, Dan L. Longo, Eric K. Moses, Claudia Schurmann, Liina Tserel, Albert Hofman, Wouter den Hollander, Grant W. Montgomery, Eva Reinmaa, Samuli Ripatti, Andrew B. Singleton, Alexandra Zhernakova, Marcel P. van der Brug, Annette Peters, Silva Kasela, Kerry J. Ressler, Alicia K. Smith, Joanne E. Curran, Lisette Stolk, Joyce B. J. van Meurs, Jeroen van Rooij, Tõnu Esko, Iiris Hovatta, Myriam Fornage, Barbara E. Stranger, Hanieh Yaghootkar, Leif Steil, Luigi Ferrucci, Johannes Kettunen, Mark R. Cookson, Alexander Teumer, Ron Korstanje, Bruce M. Psaty, Tianxiao Huan, Andres Metspalu, Christian Herder, Shannon Bean, Jian Yang, Lili Milani, Fernando Rivadeneira, Allan F. McRae, Veikko Salomaa, Towfique Raj, Yii-Der Ida Chen, Robert L. Hanson, G. Gregory Neely, Daniel Levy, Raphael Gibbs, Andrew D. Johnson, Sampath Arepalli, Margreet Kloppenburg, Melanie Waldenberger

Publikováno v: Nature Communications, 6
Nature Communications, 6:8570. Nature Publishing Group
Nature Communications
Nature Communications, 6. Nature Publishing Group
Nat. Commun. 6:8570 (2015)

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of Europ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71413550aa63aced5d1a8e2553a20fd
https://doi.org/10.1038/ncomms9570