Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nomalie Jaya"'
Autor:
Edward Koepf, Sarah L Demmon, Marisa K. Joubert, Swapnil Bhargava, Phillip Smith, Philip Tsai, Nomalie Jaya, Doreen Ciolek, Melody Trexler-Schmidt, Jennifer Halley
Publikováno v:
Biologicals. 67:9-20
Identification of Critical Quality Attributes (CQAs) and subsequent characterization in process development studies are the key elements of quality by design (QbD) for biopharmaceutical products. Since the inception of ICH Q8R2, several articles have
Autor:
Thorsten Verch, Cristiana Campa, Cyrille C. Chéry, Ruth Frenkel, Timothy Graul, Nomalie Jaya, Bassam Nakhle, Jeremy Springall, Jason Starkey, Jette Wypych, Todd Ranheim
Publikováno v:
The AAPS journal. 24(1)
Analytical methods are utilized throughout the biopharmaceutical and vaccines industries to conduct research and development, and to help control manufacturing inputs and outputs. These analytical methods should continuously provide quality data to s
Publikováno v:
Analytical Chemistry. 89:11227-11235
Peptide mapping with mass spectrometry (MS) detection is a powerful technique routinely used for interrogating physicochemical properties of proteins. Peptide mapping benefits from an efficient front-end separation to increase selectivity and reduce
Publikováno v:
Analytical Chemistry. 89:11236-11242
Reversed phase liquid chromatography with mass spectrometry (RPLC-MS) peptide mapping is routinely used for interrogating molecular and structural attributes such as amino acid composition, sequence variants, and post-translational modifications (PTM
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 145:91-97
Fragmentation of monoclonal antibodies is a critical quality attribute routinely monitored to assess the purity and integrity of the product from development to commercialization. Cleavage in the upper hinge region of IgG1 monoclonal antibodies is a
Publikováno v:
Analytical chemistry. 89(21)
Peptide mapping with mass spectrometry (MS) detection is a powerful technique routinely used for interrogating physicochemical properties of proteins. Peptide mapping benefits from an efficient front-end separation to increase selectivity and reduce
Autor:
Justin L. P. Benesch, Andrew Baldwin, Gillian R. Hilton, Elizabeth Vierling, Matthew F. Bush, Florian Stengel, Eman Basha, Hadi Lioe, Nomalie Jaya
Small Heat-Shock Proteins (sHSPs) are a family of molecular chaperones that help prevent irreversible aggregation through binding non-native target proteins to form large and heterogeneous complexes. These sHSP:target complexes are an integral part o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb33b384b190e0a8cd9acd2b4affa3d
https://ora.ox.ac.uk/objects/uuid:70135646-cbeb-4748-99c4-15fbee5e2e98
https://ora.ox.ac.uk/objects/uuid:70135646-cbeb-4748-99c4-15fbee5e2e98
Autor:
Justin L. P. Benesch, Andrew Baldwin, Elizabeth Vierling, Alexander J. Painter, Lewis E. Kay, Carol V. Robinson, Florian Stengel, Nomalie Jaya, Eman Basha
Publikováno v:
Proceedings of the National Academy of Sciences; Vol 107
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Small Heat Shock Proteins (sHSPs) are a diverse family of molecular chaperones that prevent protein aggregation by binding clients destabilized during cellular stress. Here we probe the architecture and dynamics of complexes formed between an oligome
Publikováno v:
Proceedings of the National Academy of Sciences. 106:15604-15609
Small heat shock proteins (sHSPs) serve as a first line of defense against stress-induced cell damage by binding and maintaining denaturing proteins in a folding-competent state. In contrast to the well-defined substrate binding regions of ATP-depend
Publikováno v:
Electrophoresis. 36(21-22)
Characterization of both the acidic and basic regions of imaged capillary isoelectric focusing (icIEF) profile of an IgG1 antibody was achieved through preparative immobilized pH gradient isoelectric focusing (IPG-IEF) fractionation. Recent attempts