Ambimodal Bispericyclic [6 + 4]/[4 + 6] Transition State Competes with Diradical Pathways in the Cycloheptatriene Dimerization: Dynamics and Experimental Characterization of Thermal Dimers

Autor: Qingyang Zhou, Mathias K. Thøgersen, Nomaan M. Rezayee, Karl Anker Jørgensen, K. N. Houk

Publikováno v: Zhou, Q, Thøgersen, M K, Rezayee, N M, Jørgensen, K A & Houk, K N 2022, ' Ambimodal Bispericyclic [6 + 4]/[4 + 6] Transition State Competes with Diradical Pathways in the Cycloheptatriene Dimerization : Dynamics and Experimental Characterization of Thermal Dimers ', Journal of the American Chemical Society, vol. 144, no. 48, pp. 22251-22261 . https://doi.org/10.1021/jacs.2c10407

The thermal dimerization of cycloheptatriene is predicted to occur by a concerted [6 + 4] cycloaddition via an ambimodal [6 + 4]/[4 + 6] transition state (TS) and a competing stepwise diradical (6 + 2) cycloaddition; both dimers subsequently undergo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcca48fb3868d6292ba653226c72491
https://doi.org/10.1021/jacs.2c10407

An Asymmetric SN2 Dynamic Kinetic Resolution

Autor: Nomaan M. Rezayee, Gabriel J. Reyes-Rodríguez, Johannes N. Lamhauge, Kendall N. Houk, Chenxi Lu, Sif T. Linde, Karl Anker Jørgensen, Valdemar J. Enemærke

Publikováno v: Rezayee, N M, Enemærke, V J, Linde, S T, Lamhauge, J N, Reyes-Rodríguez, G J, Jørgensen, K A, Lu, C & Houk, K N 2021, ' An Asymmetric S N 2 Dynamic Kinetic Resolution ', Journal of the American Chemical Society, vol. 143, no. 19, pp. 7509-7520 . https://doi.org/10.1021/jacs.1c02193

The SN2 reaction exhibits the classic Walden inversion, indicative of the stereospecific backside attack of the nucleophile on the stereogenic center. Observation of the inversion of the stereocenter provides evidence for an SN2-type displacement. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de56545caa73ef1a2a644ac7fe9c3867
https://doi.org/10.1021/jacs.1c02193

Prevalence of Diarylprolinol Silyl Ethers as Catalysts in Total Synthesis and Patents

Autor: Gabriel J. Reyes-Rodríguez, Karl Anker Jørgensen, Andreu Vidal-Albalat, Nomaan M. Rezayee

Publikováno v: Reyes-Rodríguez, G J, Rezayee, N M, Vidal-Albalat, A & Jørgensen, K A 2019, ' Prevalence of Diarylprolinol Silyl Ethers as Catalysts in Total Synthesis and Patents ', Chemical Reviews, vol. 119, no. 6, pp. 4221-4260 . https://doi.org/10.1021/acs.chemrev.8b00583

Diarylprolinol silyl ethers are among the most utilized stereoselective organocatalysts for the construction of complex molecules. With their debut in 2005, these catalysts have been applied in numerous method developments primarily leveraging enamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287a13271f0a9d70609714c243366bc5
https://doi.org/10.1021/acs.chemrev.8b00583

Oxidative organocatalysed enantioselective coupling of indoles with aldehydes that forms quaternary carbon stereocentres

Autor: Line Næsborg, Karl Anker Jørgensen, Henriette N. Tobiesen, Thanh V. Q. Nguyen, Nomaan M. Rezayee, Vibeke Henriette Lauridsen

Publikováno v: Chemical Science
Rezayee, N, Lauridsen, V H, Naesborg, L, Nguyen, T V Q, Tobiesen, H N & Jorgensen, K A 2019, ' Oxidative organocatalysed enantioselective coupling of indoles with aldehydes that forms quaternary carbon stereocentres ', Chemical Science, vol. 10, no. 12, pp. 3586-3591 . https://doi.org/10.1039/c9sc00196d

The first organocatalysed, metal-free cross-nucleophile coupling of indoles with α-branched aldehydes forming acyclic stereoselective quaternary carbon centres is presented.
The first organocatalysed, metal-free cross-nucleophile coupling of in

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https://pubmed.ncbi.nlm.nih.gov/30996950

Base-Free Iridium-Catalyzed Hydrogenation of Esters and Lactones

Autor: Timothy P. Brewster, Zuzana Culakova, Melanie S. Sanford, Nomaan M. Rezayee, Karen I. Goldberg

Publikováno v: ACS Catalysis. 6:3113-3117

Half-sandwich iridium bipyridine complexes catalyze the hydrogenation of esters and lactones under base-free conditions. The reactions proceed with a variety of ester and lactone substrates. Mechanistic studies implicate a pathway involving rate-limi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d0544b3aedf8ec93ff2b5355df43853
https://doi.org/10.1021/acscatal.6b00263