Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

Autor: Sharon A. Williams, Louise E. Purton, Jacqueline E. Noll, Andrew C.W. Zannettino

Publikováno v: Blood Cancer Journal

In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains specific anatomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de97cf88e697ebf8edca77857ba1525e
https://doi.org/10.1038/bcj.2012.38

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.

Autor: Bhattacharjee R; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., Jolly LA; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia.; School of Biomedicine, The University of Adelaide, Adelaide, SA, 5005, Australia., Corbett MA; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., Wee IC; Discipline of Anatomy and Pathology, School of Biomedicine, The University of Adelaide, Adelaide, SA, 5005, Australia., Rao SR; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Proteomics, Metabolomics and MS-imaging Core Facility, South Australian Health and Medical Research Institute, and Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia., Gardner AE; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., Ritchie T; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., van Hugte EJH; Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, 6500, HB, the Netherlands., Ciptasari U; Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, 6500, HB, the Netherlands., Piltz S; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia.; School of Biomedicine, The University of Adelaide, Adelaide, SA, 5005, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia., Noll JE; School of Biomedicine, Faculty of Health and Medical Sciences, University of Adelaide and Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia., Nazri N; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Childhood Dementia Research Group, College of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Bedford Park, Adelaide, SA, 5042, Australia., van Eyk CL; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., White M; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia.; School of Biomedicine, The University of Adelaide, Adelaide, SA, 5005, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia., Fornarino D; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., Poulton C; Undiagnosed Diseases Program, Genetic Services of WA, King Edward Memorial Hospital, Subiaco, WA, 6008, Australia., Baynam G; Undiagnosed Diseases Program, Genetic Services of WA, King Edward Memorial Hospital, Subiaco, WA, 6008, Australia.; Western Australian Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco, WA, 6008, Australia.; Rare Care Centre, Perth Children's Hospital, Nedlands, WA, 6009, Australia., Collins-Praino LE; Discipline of Anatomy and Pathology, School of Biomedicine, The University of Adelaide, Adelaide, SA, 5005, Australia., Snel MF; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Proteomics, Metabolomics and MS-imaging Core Facility, South Australian Health and Medical Research Institute, and Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia., Nadif Kasri N; Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, 6500, HB, the Netherlands., Hemsley KM; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Childhood Dementia Research Group, College of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Bedford Park, Adelaide, SA, 5042, Australia., Thomas PQ; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia.; School of Biomedicine, The University of Adelaide, Adelaide, SA, 5005, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia., Kumar R; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia., Gecz J; Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia. jozef.gecz@adelaide.edu.au.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia. jozef.gecz@adelaide.edu.au.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 08; Vol. 15 (1), pp. 1210. Date of Electronic Publication: 2024 Feb 08.

Calorie restriction has no effect on bone marrow tumour burden in a Vk*MYC transplant model of multiple myeloma.

Autor: Bradey AL; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Fitter S; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Duggan J; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Wilczek V; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Williams CMD; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Cheney EA; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Noll JE; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Tangseefa P; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia., Panagopoulos V; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia. bill.panagopoulos@adelaide.edu.au.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia. bill.panagopoulos@adelaide.edu.au., Zannettino ACW; Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia.; Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia.; Department of Haematology, Royal Adelaide Hospital, Adelaide, Australia.; Central Adelaide Local Health Network, Adelaide, Australia.

Publikováno v: Scientific reports [Sci Rep] 2022 Jul 30; Vol. 12 (1), pp. 13128. Date of Electronic Publication: 2022 Jul 30.

CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.

Autor: Fitter S; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Bradey AL; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Kok CH; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Noll JE; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Wilczek VJ; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Venn NC; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia., Law T; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia., Paisitkriangkrai S; School of Computer Science, The University of Adelaide, Adelaide, SA, Australia., Story C; Department of Haematology-Oncology, Women's and Children's Hospital, Adelaide, SA, Australia., Saunders L; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Department of Haematology-Oncology, Women's and Children's Hospital, Adelaide, SA, Australia., Dalla Pozza L; Cancer Centre for Children at The Children's Hospital at Westmead, Westmead, NSW, Australia., Marshall GM; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.; School of Women's and Children's Health, University of NSW, Sydney, NSW, Australia., White DL; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Sutton R; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.; School of Women's and Children's Health, University of NSW, Sydney, NSW, Australia., Zannettino ACW; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Revesz T; Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.; Department of Haematology-Oncology, Women's and Children's Hospital, Adelaide, SA, Australia.

Publikováno v: British journal of haematology [Br J Haematol] 2021 Apr; Vol. 193 (1), pp. 171-175. Date of Electronic Publication: 2021 Feb 23.

Characterization of the role of Samsn1 loss in multiple myeloma development.

Autor: Friend NL; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Hewett DR; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Panagopoulos V; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Noll JE; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Vandyke K; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Mrozik KM; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Fitter S; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia., Zannettino ACW; Myeloma Research Laboratory Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide Adelaide Australia.; Precision Medicine Theme South Australian Health and Medical Research Institute Adelaide Australia.; Central Adelaide Local Health Network Adelaide Australia.

Publikováno v: FASEB bioAdvances [FASEB Bioadv] 2020 Aug 05; Vol. 2 (9), pp. 554-572. Date of Electronic Publication: 2020 Aug 05 (Print Publication: 2020).