Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nolan R. McGrady"'
Autor:
Michael L. Risner, Marcio Ribeiro, Nolan R. McGrady, Bhanu S. Kagitapalli, Xitiz Chamling, Donald J. Zack, David J. Calkins
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling nanotubes, gap junctions, and extracellular vesicles (
Externí odkaz:
https://doaj.org/article/ba8cbac6e19c414cbb766f5391c5ec38
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionIdentification of early adaptive and maladaptive neuronal stress responses is an important step in developing targeted neuroprotective therapies for degenerative disease. In glaucoma, retinal ganglion cells (RGCs) and their axons undergo
Externí odkaz:
https://doaj.org/article/6b398316a73042a495ab710828d24ef4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Neuronal type-specific physiologic heterogeneity can be driven by both extrinsic and intrinsic mechanisms. In retinal ganglion cells (RGCs), which carry visual information from the retina to central targets, evidence suggests intrinsic properties sha
Externí odkaz:
https://doaj.org/article/d3d7712c5f1048b58ecb99152f693a30
Autor:
Michael L. Risner, Silvia Pasini, Nolan R. McGrady, Karis B. D’Alessandro, Vincent Yao, Melissa L. Cooper, David J. Calkins
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-15 (2021)
Abstract Background Early challenges to axonal physiology, active transport, and ultrastructure are endemic to age-related neurodegenerative disorders, including those affecting the optic nerve. Chief among these, glaucoma causes irreversible vision
Externí odkaz:
https://doaj.org/article/94c82b4392a64c52a9266496288148af
Autor:
Nolan R. McGrady, Silvia Pasini, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, David J. Calkins
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Optic neuropathies are a major cause of visual disabilities worldwide, causing irreversible vision loss through the degeneration of retinal ganglion cell (RGC) axons, which comprise the optic nerve. Chief among these is glaucoma, in which sensitivity
Externí odkaz:
https://doaj.org/article/44603aba52ad4a869be36e73567ce630
Autor:
Louis-Philippe Croteau, Michael L. Risner, Lauren K. Wareham, Nolan R. McGrady, Xitiz Chamling, Donald J. Zack, David J. Calkins
Publikováno v:
Cells, Vol 11, Iss 20, p 3241 (2022)
Cell replacement therapies may be key in achieving functional recovery in neurodegenerative optic neuropathies diseases such as glaucoma. One strategy that holds promise in this regard is the use of human embryonic stem cell and induced pluripotent s
Externí odkaz:
https://doaj.org/article/7050f2aefc1048caa5c35aa11ef8465a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2021)
Early progression in neurodegenerative disease involves challenges to homeostatic processes, including those controlling axonal excitability and dendritic organization. In glaucoma, the leading cause of irreversible blindness, stress from intraocular
Externí odkaz:
https://doaj.org/article/98328bee1f684629a8b9579b5a1eb8ab
Autor:
Marcio Ribeiro, Nolan R. McGrady, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, David J. Calkins
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2911 (2022)
Vision loss through the degeneration of retinal ganglion cell (RGC) axons occurs in both chronic and acute conditions that target the optic nerve. These include glaucoma, in which sensitivity to intraocular pressure (IOP) causes early RGC axonal dysf
Externí odkaz:
https://doaj.org/article/12a37bfe109a4784b4724e5cf6bcee13
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheim
Externí odkaz:
https://doaj.org/article/0e88210da4b24e1b93ef7310cddc571a
Autor:
Nolan R. McGrady, Andrew M. Boal, Michael L. Risner, Magali Taiel, Jose A. Sahel, David J. Calkins
Publikováno v:
Molecular Therapy.