Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Nolan Priedigkeit"'
Autor:
Thong T. Luong, Zheqi Li, Nolan Priedigkeit, Phoebe S. Parker, Stefanie Böhm, Kyle Rapchak, Adrian V. Lee, Kara A. Bernstein
Publikováno v:
PLoS Genetics, Vol 18, Iss 9 (2022)
Human RECQL4 is a member of the RecQ family of DNA helicases and functions during DNA replication and repair. RECQL4 mutations are associated with developmental defects and cancer. Although RECQL4 mutations lead to disease, RECQL4 overexpression is a
Externí odkaz:
https://doaj.org/article/b0869b1cbb9f4c4e8c2c9dbdee82b685
Autor:
Nolan Priedigkeit, Kai Ding, William Horne, Jay K. Kolls, Tian Du, Peter C. Lucas, Jens-Uwe Blohmer, Carsten Denkert, Anna Machleidt, Barbara Ingold-Heppner, Steffi Oesterreich, Adrian V. Lee
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER)-positive breast cancer. In this study, we aimed to determine acquired genomic changes in endocrine-resistant disease. Methods We performed DNA/RNA hybri
Externí odkaz:
https://doaj.org/article/8c263986a9324a718707574875504a29
Autor:
Sara Charmsaz, Ben Doherty, Sinéad Cocchiglia, Damir Varešlija, Attilio Marino, Nicola Cosgrove, Ricardo Marques, Nolan Priedigkeit, Siobhan Purcell, Fiona Bane, Jarlath Bolger, Christopher Byrne, Philip J. O’Halloran, Francesca Brett, Katherine Sheehan, Kieran Brennan, Ann M. Hopkins, Stephen Keelan, Petra Jagust, Stephen Madden, Chiara Martinelli, Matteo Battaglini, Steffi Oesterreich, Adrian V. Lee, Gianni Ciofani, Arnold D. K. Hill, Leonie S. Young
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast cancer molecular subtypes, including oestrogen receptor-positive disease,
Externí odkaz:
https://doaj.org/article/1f3f5704f584477bb63287d1160a16a1
Autor:
John A. Martignetti, Olga Camacho-Vanegas, Nolan Priedigkeit, Catalina Camacho, Elena Pereira, Li Lin, Leopold Garnar-Wortzel, Dagny Miller, Bojan Losic, Hardik Shah, Jun Liao, Jian Ma, Pratik Lahiri, Mark Chee, Eric Schadt, Peter Dottino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 1, Pp 97-103 (2014)
Retrospective studies have demonstrated that nearly 50% of patients with ovarian cancer with normal cancer antigen 125 (CA125) levels have persistent disease; however, prospectively distinguishing between patients is currently impossible. Here, we de
Externí odkaz:
https://doaj.org/article/e663291f25024bdbb6f4e397597a489e
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004967 (2015)
Genes involved in the same function tend to have similar evolutionary histories, in that their rates of evolution covary over time. This coevolutionary signature, termed Evolutionary Rate Covariation (ERC), is calculated using only gene sequences fro
Externí odkaz:
https://doaj.org/article/094bac0dad6742bca270e4e6b6c059c8
Abstract P6-14-02: Hope for OTHERS – An organ donation program for metastatic breast cancer research
Autor:
Steffi Oesterreich, Lori Miller, Margaret Q. Rosenzweig, Tanner L. Bartholow, Megan Yates, Ashuvinee Elangovan, Laura Savariau, Allison N. Casey, Nolan Priedigkeit, Kai Ding, Abdalla Wedn, Jie Bin Liu, Daniel D. Brown, Tara Hyder, Geoffrey Pecar, Neil Carleton, Humberto Trejo Bittar, Daniel Geisler, Oscar Lopez-Nunez, Amanda M. Clark, Alan Wells, Partha Roy, Shannon Puhalla, Naomi Howard, Christine Needles, Susan Trent, Stephanie Walker, Christine Hodgdon, Rohit Bhargava, Jennifer M. Atkinson, Adrian V. Lee
Publikováno v:
Cancer Research. 83:P6-14
Background: Previous studies have shown that rapid autopsies (RA) provide a unique opportunity for tissue collection from patients who succumb to the disease. Because cancer patients are unable to donate their organs to other people, this program pro
Autor:
Paolo Tarantino, Samuel M. Niman, Timothy K. Erick, Nolan Priedigkeit, Beth T. Harrison, Antonio Giordano, Faina Nakhlis, Jennifer R. Bellon, Tonia Parker, Sarah Strauss, Qingchun Jin, Tari A. King, Beth A. Overmoyer, Giuseppe Curigliano, Meredith M. Regan, Sara M. Tolaney, Filipa Lynce
Publikováno v:
European Journal of Cancer. 174:277-286
HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Patients diagnosed with HER2-negative IBC between December 1999
Autor:
Steffi Oesterreich, Adrian V. Lee, Peter C. Lucas, Esther Elishaev, Adam M. Brufsky, Ronald L. Hamilton, Jose P. Leone, Jens-Uwe Blohmer, Carsten Denkert, Maria M. Karsten, Kurt R. Weiss, Rohit Bhargava, Michelle M. Boisen, Rebecca J. Watters, Amir Bahreini, Ethan S. Sokol, Ryan J. Hartmaier, Nolan Priedigkeit, Ahmed Basudan
Table S1. Clinicopathological characteristics and sample distribution by site Table S2. Primers/probes design for ddPCR (ESR1, EIF2C, AP3P1) Table S3. Raw nanoString counts Table S4. Normalized copy number calls (ER+ samples) Table S5. Normalized cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9e59f5e3d10c1d4f9b6cf3550a23c1
https://doi.org/10.1158/1541-7786.22513387
https://doi.org/10.1158/1541-7786.22513387
Autor:
Steffi Oesterreich, Adrian V. Lee, Peter C. Lucas, Esther Elishaev, Adam M. Brufsky, Ronald L. Hamilton, Jose P. Leone, Jens-Uwe Blohmer, Carsten Denkert, Maria M. Karsten, Kurt R. Weiss, Rohit Bhargava, Michelle M. Boisen, Rebecca J. Watters, Amir Bahreini, Ethan S. Sokol, Ryan J. Hartmaier, Nolan Priedigkeit, Ahmed Basudan
Figure S1: Genomic organization of ESR1 nanoString probes Figure S2: Correlation of ESR1 amplification with mRNA expression Figure S3: ESR1 copy number status in ER+ primary-metastasis pairs Figure S4: Oncoprint visualization of copy number alteratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb4ca70d3e077735a7368e8ee70c5eb
https://doi.org/10.1158/1541-7786.22513390.v1
https://doi.org/10.1158/1541-7786.22513390.v1
Autor:
John A. Martignetti, Peter Dottino, Morten Mau-Sørensen, Mansoor R. Mirza, Michael Kauffman, Tami Rashal, Yosef Landesman, Dilara McCauley, Sharon Shacham, Jean-Noel Billaud, Richard Halpert, Rileen Sinha, Rong Chen, Andrew Uzilov, Robert Sebra, Tamara Kalir, Faisal Khan, Michael Donovan, Estefania Rodriguez, Nolan Priedigkeit, Fei Huang, Susan J. Ramus, Brad R. Evans, Elena Pereira, Eva Kalir, John F. Gerecitano, Nashat Y. Gabrail, Albiruni R.A. Razak, Thomas R. Silvers, Sandra Catalina Camacho, Ying Chen
Supplementary Material and Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd94388a9ace123fadf893e903e3182
https://doi.org/10.1158/1078-0432.22464165.v1
https://doi.org/10.1158/1078-0432.22464165.v1