Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nolan J, Hoffman"'
Autor:
Mehdi R. Belhaj, Nathan G. Lawler, John A. Hawley, David I. Broadhurst, Nolan J. Hoffman, Stacey N. Reinke
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Introduction: The AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis that becomes activated by exercise and binds glycogen, an important energy store required to meet exercise-induced energy demands. Disruption of AMPK-gl
Externí odkaz:
https://doaj.org/article/1ba21c4a7dcf4dbbbf6f821543c6071f
Autor:
Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy balance and metabolism and binds glycogen, the primary storage form of glucose in liver and skeletal muscle. The effects of disrupting whole-body AMPK-glycogen interact
Externí odkaz:
https://doaj.org/article/e253ca0f9f6143b8b3755cdb3ed0c4b8
Autor:
Hani Jieun Kim, Taiyun Kim, Nolan J. Hoffman, Di Xiao, David E. James, Sean J. Humphrey, Pengyi Yang
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108771- (2021)
Summary: Mass spectrometry (MS)-based phosphoproteomics has revolutionized our ability to profile phosphorylation-based signaling in cells and tissues on a global scale. To infer the action of kinases and signaling pathways in phosphoproteomic experi
Externí odkaz:
https://doaj.org/article/6d20131845ba4856a2d27bc5294dac18
Autor:
Nolan J. Hoffman, Jamie Whitfield, Natalie R. Janzen, Mehdi R. Belhaj, Sandra Galic, Lisa Murray-Segal, William J. Smiles, Naomi X.Y. Ling, Toby A. Dite, John W. Scott, Jonathan S. Oakhill, Robert Brink, Bruce E. Kemp, John A. Hawley
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101048- (2020)
Objective: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module (CBM). However, the phys
Externí odkaz:
https://doaj.org/article/87aacaf855cb400a99375db49d1f3201
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Accumulation of excess saturated free fatty acids such as palmitate (PAL) in skeletal muscle leads to reductions in mitochondrial integrity, cell viability and differentiation. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic
Externí odkaz:
https://doaj.org/article/22a343a4b0de4a26bb26abcc3985f5b2
Publikováno v:
Metabolites, Vol 11, Iss 3, p 151 (2021)
Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molec
Externí odkaz:
https://doaj.org/article/bbea208ac72e46c0ad4d72d34b90b2ed
Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle
Autor:
Robert S. Lee-Young, Nolan J. Hoffman, Kate T. Murphy, Darren C. Henstridge, Dorit Samocha-Bonet, Andrew L. Siebel, Peter Iliades, Borivoj Zivanovic, Yet H. Hong, Timothy D. Colgan, Michael J. Kraakman, Clinton R. Bruce, Paul Gregorevic, Glenn K. McConell, Gordon S. Lynch, Grant R. Drummond, Bronwyn A. Kingwell, Jerry R. Greenfield, Mark A. Febbraio
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1083-1091 (2016)
Objective: The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehyd
Externí odkaz:
https://doaj.org/article/b7a0d2f504b14b63ab5ea39dfdc8387f
Autor:
Maximilian Kleinert, Benjamin L. Parker, Rima Chaudhuri, Daniel J. Fazakerley, Annette Serup, Kristen C. Thomas, James R. Krycer, Lykke Sylow, Andreas M. Fritzen, Nolan J. Hoffman, Jacob Jeppesen, Peter Schjerling, Markus A. Ruegg, Bente Kiens, David E. James, Erik A. Richter
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 646-655 (2016)
Objective: We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1 inhibition had no effect. Therefore, we tested the hypothesis that mTORC2 regulates lipid metaboli
Externí odkaz:
https://doaj.org/article/db4cfad4b24e438e88473b12dcfae495
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Publikováno v:
eLife, Vol 7 (2018)
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://doaj.org/article/8a5796fc74b24c25b9c3c989e6b15e61
Autor:
Samuel Rogers, Rachael A. McCloy, Benjamin L. Parker, Rima Chaudhuri, Velimir Gayevskiy, Nolan J. Hoffman, D. Neil Watkins, Roger J. Daly, David E. James, Andrew Burgess
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 45-52 (2015)
The presence or absence of a phosphorylation on a substrate at any particular point in time is a functional readout of the balance in activity between the regulatory kinase and the counteracting phosphatase. Understanding how stable or short-lived a
Externí odkaz:
https://doaj.org/article/46621992fe4a45f4926e6cca55eceab8