Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nolan Casey"'
Autor:
Rebecca K Davidson, Staci A Weaver, Nolan Casey, Sukrati Kanojia, Elise Hogarth, Rebecca Schneider Aguirre, Emily K Sims, Carmella Evans-Molina, Jason M Spaeth
Publikováno v:
J Mol Endocrinol
Type 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function and identity. Pdx1 activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b6cf1d3f5ce8d9161120ca187f6ac2
https://doi.org/10.1530/jme-22-0011
https://doi.org/10.1530/jme-22-0011
Publikováno v:
Journal of Coastal Research, 2016 Sep 01. 32(5), 1016-1024.
Externí odkaz:
https://www.jstor.org/stable/43893615
Autor:
Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03ae668fe75f1bb64d63f350f20ed1
https://doi.org/10.2337/figshare.22236679
https://doi.org/10.2337/figshare.22236679
Publikováno v:
Diabetes. 71
During diabetes progression, a subset of failing β-cells incurs a loss of transcription factors (TFs) such as Pdx1, which drives expression of numerous β-cell functional genes including Ins2, MafA, and Slc2a2. Like other TFs, Pdx1 requires the recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da70916689feae14726db27e9877aea
https://doi.org/10.2337/db22-204-or
https://doi.org/10.2337/db22-204-or
Publikováno v:
Diabetes. 71
The main function of the pancreatic β-cell is glucose-stimulated insulin secretion (GSIS) which serves to maintain whole body glucose homeostasis. Under type 2 diabetic conditions, a subset of β-cells fail and lose expression of key transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::476b3853686f7a7f3aa672518202afbd
https://doi.org/10.2337/db22-1447-p
https://doi.org/10.2337/db22-1447-p
Publikováno v:
Castanea, 2010 Dec 01. 75(4), 506-516.
Externí odkaz:
https://www.jstor.org/stable/41058099
Publikováno v:
Diabetes. 70
A key feature of type 1 and type 2 diabetes is insufficient functional β-cell mass. Strategies to augment functional β-cell mass include directed differentiation of embryonic stem cells towards a β-cell fate, which requires extensive knowledge of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815f759e45e313bc646934e08134ac42
https://doi.org/10.2337/db21-177-or
https://doi.org/10.2337/db21-177-or
Publikováno v:
Diabetes. 70
Diabetes progression is partly characterized by a loss of key transcription factors (TFs) in a subset of failing β-cells. Among these TFs is Pdx1, which coordinates the expression of numerous genes related to β-cell function (MafA, Ins2, Ucn3), mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295ca543599e76d3f5dd04a1c9b54d26
https://doi.org/10.2337/db21-1243-p
https://doi.org/10.2337/db21-1243-p
Publikováno v:
Diabetes. 70
Pancreatic β-cells are crucial for glucose-stimulated insulin secretion (GSIS) and whole-body glucose homeostasis. Dysfunctional β-cell mass results in diabetes mellitus (DM), a growing pandemic causing global economic burden. Pancreas-enriched tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a79bb643c299bf11521080fba77fdb1
https://doi.org/10.2337/db21-1247-p
https://doi.org/10.2337/db21-1247-p
Publikováno v:
Transportation Research Record; January 2005, Vol. 1918 Issue: 1 p98-107, 10p