Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.

Autor: Ellis SLS; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Dada S; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Nohara LL; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Saranchova I; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Munro L; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Pfeifer CG; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Eyford BA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Morova T; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Williams DE; Departments of Chemistry and Earth Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Cheng P; Departments of Chemistry and Earth Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Lack NA; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; School of Medicine, Koç University, Istanbul, Türkiye., Andersen RJ; Departments of Chemistry and Earth Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Jefferies WA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Aug 10; Vol. 14, pp. 1119620. Date of Electronic Publication: 2023 Aug 10 (Print Publication: 2023).

Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours.

Autor: Dada S; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Ellis SLS; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Wood C; Biotechnology - Biomedical Science and Technology (BST), University of Applied Sciences, Mannheim, Germany., Nohara LL; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Dreier C; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Biotechnology - Biomedical Science and Technology (BST), University of Applied Sciences, Mannheim, Germany., Garcia NH; Pascal Biosciences, Seattle, WA, United States., Saranchova I; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Munro L; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Pfeifer CG; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Eyford BA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Kari S; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Garrovillas E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Caspani G; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Al Haddad E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Gray PW; Pascal Biosciences, Seattle, WA, United States., Morova T; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Lack NA; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; School of Medicine, Koç University, Istanbul, Türkiye., Andersen RJ; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada., Tjoelker L; Pascal Biosciences, Seattle, WA, United States., Jefferies WA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.; Department of Zoology, University of British Columbia, Vancouver, BC, Canada.; Department of Urological Science, University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Feb 22; Vol. 13, pp. 982082. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2022).

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi.

Autor: Herrera LJ; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America., Brand S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom., Santos A; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America., Nohara LL; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America., Harrison J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom., Norcross NR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom., Thompson S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom., Smith V; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom., Lema C; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America., Varela-Ramirez A; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America., Gilbert IH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom., Almeida IC; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America., Maldonado RA; The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Apr 29; Vol. 10 (4), pp. e0004540. Date of Electronic Publication: 2016 Apr 29 (Print Publication: 2016).

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.

Autor: Bertin S; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Aoki-Nonaka Y; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.; Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, 5274 Gakkocho 2-ban-cho, Chuo-ku, Niigata 951-8514, Japan., de Jong PR; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Nohara LL; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada., Xu H; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada., Stanwood SR; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada., Srikanth S; Department of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA., Lee J; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., To K; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Abramson L; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Yu T; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Han T; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Touma R; Department of Pediatrics University of California, San Diego, La Jolla, CA 92093, USA., Li X; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., González-Navajas JM; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Herdman S; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Corr M; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Fu G; Department of Immunology and Microbial Science, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian 361102, China., Dong H; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Gwack Y; Department of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA., Franco A; Department of Pediatrics University of California, San Diego, La Jolla, CA 92093, USA., Jefferies WA; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada., Raz E; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Publikováno v: Nature immunology [Nat Immunol] 2014 Nov; Vol. 15 (11), pp. 1055-1063. Date of Electronic Publication: 2014 Oct 05.

Lysophosphatidylcholine triggers TLR2- and TLR4-mediated signaling pathways but counteracts LPS-induced NO synthesis in peritoneal macrophages by inhibiting NF-κB translocation and MAPK/ERK phosphorylation.

Autor: Carneiro AB; Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil ; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular- INCT-EM, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Iaciura BM, Nohara LL, Lopes CD, Veas EM, Mariano VS, Bozza PT, Lopes UG, Atella GC, Almeida IC, Silva-Neto MA

Publikováno v: PloS one [PLoS One] 2013 Sep 30; Vol. 8 (9), pp. e76233. Date of Electronic Publication: 2013 Sep 30 (Print Publication: 2013).