Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Noha Maklad"'
Autor:
Matthew M. Heeney, Miguel R. Abboud, Jessie Githanga, Baba P. D. Inusa, Julie Kanter, Alan D. Michelson, Videlis Nduba, Victor Musiime, Mohini Apte, Adlette Inati, Amar M. Taksande, Marielle Andersson, Magnus Åstrand, Noha Maklad, Mohammad Niazi, Anders Himmelmann, Anders R. Berggren
Publikováno v:
Blood. 140(13)
The phase 3 HESTIA3 study assessed the efficacy and safety of the reversible P2Y12 inhibitor ticagrelor vs placebo in preventing vaso-occlusive crises in pediatric patients with sickle cell disease (SCD). Patients aged 2 to 17 years were randomly ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d100cd709d2e45d7d920ee77c98509
https://pubmed.ncbi.nlm.nih.gov/36173660
https://pubmed.ncbi.nlm.nih.gov/36173660
Autor:
Kimberly F. Fennell, Zhijun Kang, Hirokazu Ueno, William E. Hoffman, Mihály Hajós, Thomas Allen Chappie, Mary Piotrowski, Noha Maklad, Jayvardhan Pandit, John M. Humphrey, Anne W. Schmidt, Edward X. Yang, Patrick Robert Verhoest, Bethany L. Kormos, Jiemin Lu, Eric P. Arnold, Cheng Chang, Christopher J. Schmidt, Robin J. Kleiman, Rebecca E. O’Connor, John F. Harms, Scot Richard Mente, Christopher John Helal, Tracey Boyden, Chewah Lee, Laura McDowell, Michael D. Forman
Publikováno v:
Journal of Medicinal Chemistry. 60:5673-5698
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify potent PDE2A inhibitors with improved brain pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146c156bc1785305e9a93e6cd8b6147
https://doi.org/10.1021/acs.jmedchem.7b00397
https://doi.org/10.1021/acs.jmedchem.7b00397
Autor:
Christopher J. Helal, Eric P. Arnold, Tracey L. Boyden, Cheng Chang, Thomas A. Chappie, Kimberly F. Fennell, Michael D. Forman, Mihaly Hajos, John F. Harms, William E. Hoffman, John M. Humphrey, Zhijun Kang, Robin J. Kleiman, Bethany L. Kormos, Erik A. LaChapelle, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E. O’Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W. Schmidt, Christopher J. Schmidt, Hirokazu Ueno, Patrick R. Verhoest, Edward X. Yang
Publikováno v:
Journal of medicinal chemistry. 61(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284ec23899d97800205ac23dc80d4562
https://pubmed.ncbi.nlm.nih.gov/28574706
https://pubmed.ncbi.nlm.nih.gov/28574706
Autor:
Mihály Hajós, William E. Hoffman, John F. Harms, Mary Piotrowski, Christopher J. Schmidt, Eric P. Arnold, Robin J. Kleiman, Edward X. Yang, Adam Ogden, Patricia A. Seymour, Jiemin Lu, Ethan Lawrence Fisher, Nichole Vansell, Patrick Robert Verhoest, Jayvardhan Pandit, Zhijun Kang, Hirokazu Ueno, John M. Humphrey, Bethany L. Kormos, Dina McGinnis, Thomas Allen Chappie, Noha Maklad, Laura McDowell, Cheng Chang, Rebecca E. O’Connor, Chewah Lee, Tracey Boyden, Christopher J. O’Donnell, Christopher John Helal
Publikováno v:
Journal of medicinal chemistry. 61(3)
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408cc7b21c310fe120ce681146fe8fb5
https://pubmed.ncbi.nlm.nih.gov/29293004
https://pubmed.ncbi.nlm.nih.gov/29293004
Autor:
Angela C. Doran, John T. Lazzaro, Ivan Viktorovich Efremov, Allen J. Duplantier, Kenneth G. Kraus, Sheryl A. McCarthy, Douglas K. Spracklin, Lei Zhang, Jiemin Lu, Theresa J. O’Sullivan, Judith A. Siuciak, Ashley N. Hanks, Alan H. Ganong, Bruce N. Rogers, Jessica A. Haas, John Candler, Noha Maklad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2524-2529
The discovery, synthesis and SAR of a novel series of 3-benzyl-1,3-oxazolidin-2-ones as positive allosteric modulators (PAMs) of mGluR2 is described. Expedient hit-to-lead work on a single HTS hit led to the identification of a ligand-efficient and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae2f0792ed614fca82f8250d78a7836
https://doi.org/10.1016/j.bmcl.2009.03.032
https://doi.org/10.1016/j.bmcl.2009.03.032
Publikováno v:
Canadian Journal of Chemistry. 84:561-568
Treatment of 6-(hydroxymethyl)furo[2,3-d]pyrimidin-2(3H)-one (2) with 1-iodoalkanes and potassium carbonate resulted in predominant formation of N3 (and minor amounts of O2) alkylated regioisomers. Treatment of the 3-alkyl products (3) with thionyl c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d94b8a1559361e40fa364b60daca0fb0
https://doi.org/10.1139/v06-042
https://doi.org/10.1139/v06-042
Autor:
Noha Maklad
Publikováno v:
ChemInform. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fd337d2e8a2c76bc17857a8fe1ea4f1
https://doi.org/10.1002/chin.201219242
https://doi.org/10.1002/chin.201219242
Autor:
Alan H. Ganong, Melinda D. Rottas, Jessica A. Haas, Sheryl A. McCarthy, Christopher J. Schmidt, Kenneth G. Kraus, Angela C. Doran, Edel Evrard, John Candler, Lei Zhang, Ashley N. Hanks, Allen J. Duplantier, Andy Q. Zhang, Noha Maklad, John T. Lazzaro, Weimin Qian, Ivan Viktorovich Efremov, Keith Jenza, Bruce N. Rogers, Michael Aaron Brodney, Judith A. Siuciak, F. David Tingley
Publikováno v:
Journal of medicinal chemistry. 54(6)
A novel series of mGluR2 positive allosteric modulators (PAMs), 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines, is herein disclosed. Structure-activity relationship studies led to potent, selective mGluR2 PAMs with excellent pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35f941c0527c9d6f18ef786569e5f3
https://pubmed.ncbi.nlm.nih.gov/21366332
https://pubmed.ncbi.nlm.nih.gov/21366332
Autor:
Allen J. Duplantier, Victoria A. Williams, James T. Downs, Stefanus J. Steyn, Subas M. Sakya, Jiemin Lu, Boris A. Chrunyk, Lain-Yen Hu, Noha Maklad, Lei Zhang, Michael John Bohanon, Stacey L. Becker, Christine A. Strick, Shenping Liu, Mary Piotrowski, Scot Richard Mente, Ayman El-Kattan, Sheehan Susan M, Mahmoud N. Mansour, Kris A. Borzilleri, Larry C. James
Publikováno v:
Journal of medicinal chemistry. 52(11)
3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystallization of 2 with the human DAAO enzyme def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf9ac2ceb83f75089e9eff06cce29e1
https://pubmed.ncbi.nlm.nih.gov/19438227
https://pubmed.ncbi.nlm.nih.gov/19438227