Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality

Autor: Singh, Sarbjit, Goo, Ja-Il, Noh, Hyojin, Lee, Sung Jae, Kim, Myoung Woo, Park, Hyejun, Jalani, Hitesh B., Lee, Kyeong, Kim, Chunsook, Kim, Won-Ki, Ju, Chung, Choi, Yongseok

Publikováno v: In Bioorganic & Medicinal Chemistry 15 February 2017 25(4):1394-1405

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Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor.

Autor: Hwang CY; Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.; Aventi, Inc., Daejeon, Korea., Yu SJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Won JK; Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea., Park SM; Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.; KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Korea., Noh H; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Lee S; Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Cho EJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Lee JH; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Lee KB; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea., Kim YJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Suh KS; Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea., Yoon JH; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Cho KH; Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. ckh@kaist.ac.kr.

Publikováno v: Cancer gene therapy [Cancer Gene Ther] 2022 Jun; Vol. 29 (6), pp. 845-858. Date of Electronic Publication: 2021 Aug 06.