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Akademický článek

LeishIF3d is a non-canonical cap-binding protein in Leishmania

Autor: Priyanka Bose, Nofar Baron, Durgeshwar Pullaiahgari, Anat Ben-Zvi, Michal Shapira

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the pre-initiation complex at the 5′ end of mRNAs driving translation initiation. The genome of Leishmania en

Externí odkaz: https://doaj.org/article/6e581d8123d14fed9f6e301731d04df2

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Akademický článek

Distinct features of the Leishmania cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated hemizygous deletion.

Autor: Nofar Baron, Nitin Tupperwar, Irit Dahan, Uzi Hadad, Geula Davidov, Raz Zarivach, Michal Shapira

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0008352 (2021)

Leishmania parasites cycle between sand-fly vectors and mammalian hosts adapting to alternating environments by stage-differentiation accompanied by changes in the proteome profiles. Translation regulation plays a central role in driving the differen

Externí odkaz: https://doaj.org/article/1aa5824e79004b0d8ab45cfc75bf2165

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Akademický článek

Characterization of an Atypical eIF4E Ortholog in Leishmania, LeishIF4E-6

Autor: Nitin Tupperwar, Rohit Shrivastava, Nofar Baron, Orli Korchev, Irit Dahan, Michal Shapira

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 23, p 12720 (2021)

Leishmania parasites are digenetic protists that shuffle between sand fly vectors and mammalian hosts, transforming from flagellated extracellular promastigotes that reside within the intestinal tract of female sand flies to the obligatory intracellu

Externí odkaz: https://doaj.org/article/422f12c63a5b4f478dc1bc26003610e0

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Akademický článek

LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in Leishmania

Autor: Rohit Shrivastava, Nitin Tupperwar, Bar Schwartz, Nofar Baron, Michal Shapira

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8, p 3979 (2021)

Leishmania parasites cycle between sand fly vectors and mammalian hosts, transforming from extracellular promastigotes that reside in the vectors’ alimentary canal to obligatory intracellular non-motile amastigotes that are harbored by macrophages

Externí odkaz: https://doaj.org/article/01a8ccabdd144638bb177f2eb41f0dee

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A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs

Autor: Mélissa Léger-Abraham, Rohit Shrivastava, Gerhard Wagner, Shimi Meleppattu, Nitin Tupperwar, Ayelet Gilad, Michal Shapira, Nofar Baron

Publikováno v: Nucleic Acids Research

Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the preinitiation complex at the 5′ end of mRNAs and regulates translation initiation. The requirement of Lei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51de8fa127ccb59a116b2719af02a5c4
http://europepmc.org/articles/PMC7192595

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Characterization of an Atypical eIF4E Ortholog in Leishmania, LeishIF4E-6

Autor: Irit Dahan, Orli Korchev, Nitin Tupperwar, Rohit Shrivastava, Michal Shapira, Nofar Baron

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12720
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12720, p 12720 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5f68f422840ebfc9af6cb49af2a3b1

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LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in Leishmania

Autor: Michal Shapira, Rohit Shrivastava, Bar Schwartz, Nofar Baron, Nitin Tupperwar

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3979, p 3979 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0df241b8e57e35159bf6a2fdb59e644
http://europepmc.org/articles/PMC8069130

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Distinct features of the Leishmania cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated heterozygous deletion

Autor: Nofar Baron, Nitin Tupperwar, Geula Davidov, Michal Shapira, Raz Zarivach

Leishmaniaparasites cycle between sand-fly vectors and mammalian hosts, adapting to alternating environments by stage-differentiation, accompanied by changes in the proteome profiles. Translation regulation plays a central role in driving the differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a829ca03777f305f1a8567e8ce7ff521

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Distinct features of the Leishmania cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated hemizygous deletion

Autor: Nitin Tupperwar, Geula Davidov, Uzi Hadad, Nofar Baron, Irit Dahan, Michal Shapira, Raz Zarivach

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0008352 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df7f2fe5a3e3a8504db8cad714279ef
https://pubmed.ncbi.nlm.nih.gov/33760809

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