Pharmacophore-based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators.

Autor: Nofal HR; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Elmaaty AA; Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Ismail MF; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt., Ali AK; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt., Abbass EM; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2400217. Date of Electronic Publication: 2024 Jun 12.