Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Noemi Alejandra Saavedra-Avila"'
Autor:
Shivani Singh, David Kanzin, Sarah Chavez, Noemi Alejandra Saavedra-Avila, Tony W. Ng, Regy Lukose, Oren Mayer, John Kim, Bing Chen, Mei Chen, Steven A. Porcelli, William R. Jacobs, Sangeeta Tiwari
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1571 (2024)
Tuberculosis (TB) continues to be a major global health burden and kills over a million people annually. New immunization strategies are required for the development of an efficacious TB vaccine that can potentially induce sterilizing immunity. In th
Externí odkaz:
https://doaj.org/article/29883398ba6c467bb279faa3db5abe23
Autor:
Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differen
Externí odkaz:
https://doaj.org/article/5d32e342b826403ea225e6efd39248ae
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Bacillus Calmette-Guerin (BCG) has been used as a vaccine against tuberculosis since 1921 and remains the only currently approved vaccine for this infection. The recent discovery that BCG protects against initial infection, and not just against progr
Externí odkaz:
https://doaj.org/article/c547c42d72854c42a6de49cfe1782ea5
Autor:
José A. Gascón, Noemi Alejandra Saavedra-Avila, Carolina Schäfer, Matthew J. Guberman-Pfeffer, Santosh Keshipeddy, Amy R. Howell, Ayax Pérez-Gallegos, Leandro J. Carreño, Neeraj K. Saini, Steven A. Porcelli
Publikováno v:
ACS Chem Biol
Activation of invariant natural killer T (iNKT) cells by α-galactosylceramides (α-GalCers) stimulates strong immune responses and potent anti-tumor immunity. Numerous modifications of the glycolipid structure have been assessed to derive activating
Autor:
Grégoire Lauvau, John Chan, Nazanin Khajoueinejad, Christopher T. Johndrow, Michael F. Goldberg, William R. Jacobs, Noemi Alejandra Saavedra-Avila, Steven A. Porcelli, Jiayong Xu, Betsy C. Herold, Tony W. Ng, Alison J. Johnson, Shajo Kunnath-Velayudhan, John Kim, Pooja Arora, Christopher Petro, Neeraj K. Saini
Publikováno v:
ImmunoHorizons. 3:161-171
During Ag priming, naive CD4+ T cells differentiate into subsets with distinct patterns of cytokine expression that dictate to a major extent their functional roles in immune responses. We identified a subset of CD4+ T cells defined by secretion of I
Autor:
Liam R. Cox, Amareeta K. Besra, Himanshu Kharkwal, Natacha Veerapen, Gurdyal S. Besra, Alan Howell, Christopher T. Johndrow, Lianjun Zhang, Noemi Alejandra Saavedra-Avila, Peter J. Jervis, Leandro J. Carreño, Elizabeth E. Evans, Steven A. Porcelli, Samantha Rothberg, Alena Donda, Steven C. Almo, Maurice Zauderer, Shalu Sharma Kharkwal, Scott J. Garforth, Jinghang Zhang
Publikováno v:
Cancer Res
CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong antitumor immunity when stimulated by glycolipid agonists. However, attempts to develop effective iNKT cell agonists for clinical applications have been thwarted by potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9e51cc5ecf1296bf2eb078435815ad
https://europepmc.org/articles/PMC8137529/
https://europepmc.org/articles/PMC8137529/
Autor:
Shajo, Kunnath-Velayudhan, Michael F, Goldberg, Neeraj K, Saini, Tony W, Ng, Pooja, Arora, Christopher T, Johndrow, Noemi Alejandra, Saavedra-Avila, Alison J, Johnson, Jiayong, Xu, John, Kim, Nazanin, Khajoueinejad, Christopher D, Petro, Betsy C, Herold, Gregoire, Lauvau, John, Chan, William R, Jacobs, Steven A, Porcelli
Publikováno v:
ImmunoHorizons
During Ag priming, naive CD4+ T cells differentiate into subsets with distinct patterns of cytokine expression that dictate to a major extent their functional roles in immune responses. We identified a subset of CD4+ T cells defined by secretion of I
Autor:
Santosh Keshipeddy, Xiangshu Wen, Weiming Yuan, Jae Ho Lo, Jérôme Le Nours, Dale I. Godfrey, Matthew J. Guberman-Pfeffer, Steven A. Porcelli, Divya Chennamadhavuni, Leandro J. Carreño, Rhys Pryce, Jamie Rossjohn, Tang Yongqing, Stewart K. Richardson, Noemi Alejandra Saavedra-Avila, Amy R. Howell, José A. Gascón, Hui-Fern Koay, Pooja Arora, Srinivasan Sundararaj
Publikováno v:
Cell chemical biology. 25(7)
Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous studies using mouse models identified sphinganine
Autor:
Tony W. Ng, Claudia Gravekamp, Steven A. Porcelli, Shalu Sharma, Noemi Alejandra Saavedra-Avila, Christopher T. Johndrow
Publikováno v:
Cancer Immunology Research. 7:A151-A151
Listeria monocytogenes (Lm) is a gram-positive bacterium associated with gastrointestinal infections. Initially, infects epithelial cells in the small intestine, then migrates to other organs where it is taken up mainly by phagocytic cells. Once phag
Publikováno v:
Clinical & Translational Immunology
Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. The most extensively st