Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Noemi A. Zambetti"'
Autor:
Noemi A. Zambetti, Eric M. J. Bindels, Paulina M. H. Van Strien, Marijke G. Valkhof, Maria N. Adisty, Remco M. Hoogenboezem, Mathijs A. Sanders, Johanna M. Rommens, Ivo P. Touw, Marc H. G. P. Raaijmakers
Publikováno v:
Haematologica, Vol 100, Iss 10 (2015)
Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and mol
Externí odkaz:
https://doaj.org/article/bd2c443f30e24086ae9bd6bbe5c5cac0
Publikováno v:
Haematologica, Vol 98, Iss 1 (2013)
Externí odkaz:
https://doaj.org/article/3d0812674494422c9436ee70293179d6
Autor:
Amanda Long, Anagha Inguva, Marina Predovic, Jarrett R. Remsberg, Thomas W. Hanigan, Stewart K. Richardson, Noemi A. Zambetti, Micah J. Niphakis, Nhi Ngo, Amy R. Howell, Cassandra L. Henry, Ari J. Firestone, Benjamin F. Cravatt, Kenneth M. Lum, Ben Huang, Kevin Shannon, Radu M. Suciu, Melissa M. Dix
Publikováno v:
Nature chemical biology, vol 17, iss 8
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack spec
Autor:
Jarrett R, Remsberg, Radu M, Suciu, Noemi A, Zambetti, Thomas W, Hanigan, Ari J, Firestone, Anagha, Inguva, Amanda, Long, Nhi, Ngo, Kenneth M, Lum, Cassandra L, Henry, Stewart K, Richardson, Marina, Predovic, Ben, Huang, Melissa M, Dix, Amy R, Howell, Micah J, Niphakis, Kevin, Shannon, Benjamin F, Cravatt
Publikováno v:
Nature chemical biology. 17(8)
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack spec
Autor:
Benjamin F. Cravatt, Noemi A. Zambetti, Anagha Inguva, Benjamin J. Huang, Jarrett R. Remsberg, Ari J. Firestone, Kevin Shannon, Jasmine C. Wong, Scott C. Kogan, Amanda M. Long, Kevin M. Haigis, Radu M. Suciu, Marina Predovic
Publikováno v:
Blood, vol 135, iss 20
Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region of Ras isoforms underlie differential posttranslational modification and subcellular trafficking, potentially resulti
Autor:
Noemi A. Zambetti, Marc H.G.P. Raaijmakers, Theresia M. Westers, Remco Hoogenboezem, A.A. van de Loosdrecht, K Kenswill, Joop H. Jansen, Athina Mylona, N M Adisty, Eline M. P. Cremers, Mathijs A. Sanders, Si Chen, Eric M.J. Bindels
Publikováno v:
Leukemia
Leukemia, 30(9), 1938-+. Nature Publishing Group
Chen, S, Zambetti, N A, Bindels, E M J, Kenswill, K, Mylona, A M, Adisty, N M, Hoogenboezem, R M, Sanders, M A, Cremers, E M P, Westers, T M, Jansen, J H, van de Loosdrecht, A A & Raaijmakers, M H G P 2016, ' Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs ', Leukemia, vol. 30, no. 9, pp. 1938-+ . https://doi.org/10.1038/leu.2016.91
Leukemia, 30, 1938-1942
Leukemia, 30, 9, pp. 1938-1942
Leukemia, 30(9), 1938-+. Nature Publishing Group
Chen, S, Zambetti, N A, Bindels, E M J, Kenswill, K, Mylona, A M, Adisty, N M, Hoogenboezem, R M, Sanders, M A, Cremers, E M P, Westers, T M, Jansen, J H, van de Loosdrecht, A A & Raaijmakers, M H G P 2016, ' Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs ', Leukemia, vol. 30, no. 9, pp. 1938-+ . https://doi.org/10.1038/leu.2016.91
Leukemia, 30, 1938-1942
Leukemia, 30, 9, pp. 1938-1942
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs
Autor:
Jasmine C. Wong, Jarrett R. Remsberg, Ari J. Firestone, Amanda M. Long, Kevin M. Haigis, Benjamin F. Cravatt, Noemi A. Zambetti, Kevin Shannon, Anagha Inguva, Radu M. Suciu
Publikováno v:
Molecular Cancer Research. 18:A25-A25
A dynamic cycle of palmitoylation and depalmitoylation stably localizes N-Ras, but not K-Ras-4b, at the plasma membrane. This selective dependency suggests that targeting palmitoylation could inhibit the growth of NRAS-mutant cancers while leaving no
Autor:
Si Chen, Paulina M. H. van Strien, Arjan A. van de Loosdrecht, Maria Athina Mylona, Remco Hoogenboezem, Eric Bindels, Noemi A. Zambetti, Ivo P. Touw, Taco W. Kuijpers, Cindy S. van der Leije, Marc H.G.P. Raaijmakers, Bram C. J. van der Eerden, Theresia M. Westers, Johannes P.T.M. van Leeuwen, Chiara Milanese, Maria Niken Adisty, Zhen Ping, Mathijs A. Sanders, Eline M. P. Cremers, Keane Jared Guillaume Kenswil, Pier G. Mastroberardino, Roland Kanaar, Thomas Vogl
Publikováno v:
Cell Stem Cell, 19(5), 613-627. Cell Press
Zambetti, N A, Ping, Z, Chen, S, Kenswil, K J G, Mylona, M A, Sanders, M A, Hoogenboezem, R M, Bindels, E M J, Adisty, M N, Van Strien, P M H, van der Leije, C S, Westers, T M, Cremers, E M P, Milanese, C, Mastroberardino, P G, van Leeuwen, J P T M, van der Eerden, B C J, Touw, I P, Kuijpers, T W, Kanaar, R, van de Loosdrecht, A A, Vogl, T & Raaijmakers, M H G P 2016, ' Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia ', Stem Cell Research, vol. 19, no. 5, pp. 613-627 . https://doi.org/10.1016/j.stem.2016.08.021
Stem Cell Research, 19(5), 613-627. Elsevier
Cell stem cell, 19(5), 613-627. Cell Press
Zambetti, N A, Ping, Z, Chen, S, Kenswil, K J G, Mylona, M A, Sanders, M A, Hoogenboezem, R M, Bindels, E M J, Adisty, M N, Van Strien, P M H, van der Leije, C S, Westers, T M, Cremers, E M P, Milanese, C, Mastroberardino, P G, van Leeuwen, J P T M, van der Eerden, B C J, Touw, I P, Kuijpers, T W, Kanaar, R, van de Loosdrecht, A A, Vogl, T & Raaijmakers, M H G P 2016, ' Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia ', Stem Cell Research, vol. 19, no. 5, pp. 613-627 . https://doi.org/10.1016/j.stem.2016.08.021
Stem Cell Research, 19(5), 613-627. Elsevier
Cell stem cell, 19(5), 613-627. Cell Press
Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and relevance to human disease remain poorly defined. Here, we show that perturbation of mesenchymal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d102a855d3cb385dbcbd2d8b47b15757
http://hdl.handle.net/11697/131073
http://hdl.handle.net/11697/131073
Autor:
Cindy S. van der Leije, Zhen Ping, Arjan van der Loosdrecht, Pier G. Mastroberardino, Keane Jared Guillaume Kenswil, Marc H.G.P. Raaijmakers, Johannes P.T.M. van Leeuwen, Thomas Vogl, Maria Athina Mylona, Eric Bindels, Bram C. J. van der Eerden, Remco Hoogenboezem, Eline M. P. Cremers, Theresia M. Westers, Kuijpers Taco, Noemi A. Zambetti, Ivo P. Touw, Chiara Milanese, Paulina M. H. van Strien, Maria Niken Adisty, Mathijs A. Sanders, Si Chen, Roland Kanaar
Publikováno v:
Blood. 128:428-428
Primary alterations of the mesenchymal niche can induce myelodysplasia and acute myeloid leukemia in mouse models, introducing a concept of niche-driven leukemogenesis (Raaijmakers et al, Nature 2010). The molecular mechanisms and human relevance of
Autor:
Remco Hoogenboezem, Eric M.J. Bindels, Maria N. Adisty, Noemi A. Zambetti, Marc H.G.P. Raaijmakers, Mathijs A. Sanders, Marijke Valkhof, Ivo P. Touw, Paulina M. H. van Strien, Johanna M. Rommens
Publikováno v:
Blood. 124:355-355
Shwachman-Diamond Syndrome (SDS) is a congenital bone marrow failure disorder characterized by neutropenia and predisposition to leukemia. SDS is associated with loss-of-function mutations in the SBDSgene, involved in ribosome biogenesis, but the cel