Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Noemí Esteras"'
Autor:
Noemí Esteras, Thomas S. Blacker, Evgeny A. Zherebtsov, Olga A. Stelmashuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102672- (2023)
The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy metabolism. Energy production and antioxidant defence employ NADH
Externí odkaz:
https://doaj.org/article/4123d5a1ee434661a0e1f99bf4759861
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Human iPSC lines represent a powerful translational model of tauopathies. We have recently described a pathophysiological phenotype of neuronal excitability of human cells derived from the patients with familial frontotemporal dementia and p
Externí odkaz:
https://doaj.org/article/1cbd9bad247941769df13f43f12c4042
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 410-422 (2017)
Tau protein inclusions are a frequent hallmark of a variety of neurodegenerative disorders. The 10+16 intronic mutation in MAPT gene, encoding tau, causes frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), by altering the spl
Externí odkaz:
https://doaj.org/article/65df10d00cd54bd19f7c8f197e04aa27
Autor:
Carolina Alquezar, Noemí Esteras, Ainhoa Alzualde, Fermín Moreno, Matilde S Ayuso, Adolfo López de Munain, Ángeles Martín-Requero
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37057 (2012)
BackgroundMutations in the progranulin (PGRN) gene, leading to haploinsufficiency, cause familial frontotemporal lobar degeneration (FTLD-TDP), although the pathogenic mechanism of PGRN deficit is largely unknown. Allelic loss of PGRN was previously
Externí odkaz:
https://doaj.org/article/8cfb0f14389d4adf9d517184e2e3f24f
Autor:
Noemí Esteras, Olga Stelmashchuk, Alexander V. Gourine, Ulugbek Zakirovich Mirkhodjaev, A. V. Berezhnov, Andrey Y. Abramov, Plamena R. Angelova, Henry Houlden, Nafisa R. Komilova
Publikováno v:
The FEBS Journal. 289:699-711
Parkinson's disease (PD) is a progressive neurodegenerative disorder induced by the loss of dopaminergic neurons in midbrain. The mechanism of neurodegeneration is associated with aggregation of misfolded proteins, oxidative stress, and mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696578e44eb019158067f9053c83d955
https://doi.org/10.1111/febs.16198
https://doi.org/10.1111/febs.16198
Autor:
Vincenzo Lariccia, Morana Jaganjac, Noemí Esteras, Marta Maiolino, Andrey Y. Abramov, Dmitri A. Rusakov, Selina Wray, Seema Qamar, Salvatore Amoroso, Olga Kopach
Publikováno v:
Alzheimer's & Dementia. 18:318-338
Introduction The second most common form of early-onset dementia-frontotemporal dementia (FTD)-is often characterized by the aggregation of the microtubule-associated protein tau. Here we studied the mechanism of tau-induced neuronal dysfunction in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca61a1e94019571e43716ed02b0548b
https://doi.org/10.1002/alz.12394
https://doi.org/10.1002/alz.12394
Autor:
Plamena R. Angelova, A. V. Kamynina, Olga M. Volpina, Andrey Y. Abramov, Noemí Esteras, D. O. Koroev
Publikováno v:
Journal of Cellular Physiology
The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein products and β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945e8d897d55559eace0f330ec85d378
https://doi.org/10.1002/jcp.30324
https://doi.org/10.1002/jcp.30324
Autor:
Evgeniy A. Zherebtsov, Olga Stelmashchuk, Andrey Y. Vinokurov, Noemí Esteras, XinPing Cheng, Plamena R. Angelova, Andrey Y. Abramov
Publikováno v:
Journal of Neurochemistry. 157:1234-1243
Brain is not homogenous and neurons from various brain regions are known to have different vulnerabilities to mitochondrial mutations and mitochondrial toxins. However, it is not clear if this vulnerability is connected to different energy metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932a4d11642d86583ffa058e8aba14f0
https://doi.org/10.1111/jnc.15239
https://doi.org/10.1111/jnc.15239
Autor:
Noemí Esteras, Andrey Y. Abramov
Publikováno v:
Free radical biologymedicine. 189
Mitochondria are unique and essential organelles that mediate many vital cellular processes including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45-related factor 2) has emerged in the last few years as an important modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743e320e5193d424346e082be8b61999
https://pubmed.ncbi.nlm.nih.gov/35918014
https://pubmed.ncbi.nlm.nih.gov/35918014
Publikováno v:
Medicinal Research Reviews. 41:770-784
The world's population aging progression renders age-related neurodegenerative diseases to be one of the biggest unsolved problems of modern society. Despite the progress in studying the development of pathology, finding ways for modifying neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2970fe50d6042e1d2705d693c519ae1e
https://doi.org/10.1002/med.21712
https://doi.org/10.1002/med.21712