Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Noelle S Williams"'
Autor:
Jugal Mohapatra, Kyuto Tashiro, Ryan L Beckner, Jorge Sierra, Jessica A Kilgore, Noelle S Williams, Glen Liszczak
Publikováno v:
eLife, Vol 10 (2021)
Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification catalyzed by the PARP1/2:HPF1 complex. As the list of PARP1/2:HPF1 substrates continues to expand, there is a need for technologies to prepare mono- and poly-ADP-r
Externí odkaz:
https://doaj.org/article/ea3c6786663341ab8b0fac2fd78370b2
Autor:
M Carmen Lafita-Navarro, Niranjan Venkateswaran, Jessica A Kilgore, Suman Kanji, Jungsoo Han, Spencer Barnes, Noelle S Williams, Michael Buszczak, Sandeep Burma, Maralice Conacci-Sorrell
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009117 (2020)
Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA re
Externí odkaz:
https://doaj.org/article/b18a09d25d7e4899a2e3c4dfd0fa497b
Autor:
Rachel Tesla, Charlotte Guhl, Gordon C. Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M. Fass, Zachary Rosenthal, Stephen J. Haggarty, Noelle S. Williams, Bruce A. Posner, Joseph M. Ready, Joachim Herz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to progranulin deficiency are not well understood, and there is curr
Externí odkaz:
https://doaj.org/article/c7ffddc3386d4b01812406f15f938067
Autor:
Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro, Yi-Heng Hao, Lizbeth Perez-Castro, Pedro A. S. Nogueira, Ashley Solmonson, Ilgen Mender, Jessica A. Kilgore, Shun Fang, Isabella N. Brown, Li Li, Emily Parks, Igor Lopes dos Santos, Mahima Bhaskar, Jiwoong Kim, Yuemeng Jia, Andrew Lemoff, Nick V. Grishin, Lisa Kinch, Lin Xu, Noelle S. Williams, Jerry W. Shay, Ralph J. DeBerardinis, Hao Zhu, Maralice Conacci-Sorrell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to t
Externí odkaz:
https://doaj.org/article/6ee60b31df8e443cb81fea064aabbe4b
Autor:
Zachary C. Rosenthal, Daniel M. Fass, N. Connor Payne, Angela She, Debasis Patnaik, Krista M. Hennig, Rachel Tesla, Gordon C. Werthmann, Charlotte Guhl, Surya A. Reis, Xiaoyu Wang, Yueting Chen, Michael Placzek, Noelle S. Williams, Jacob Hooker, Joachim Herz, Ralph Mazitschek, Stephen J. Haggarty
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-29 (2024)
Abstract Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN are one of the most common genetic causes of FTD, near ubiquitously resulting in pro
Externí odkaz:
https://doaj.org/article/0ce6be333ade4397a3f955c44b12062e
Autor:
Bray Denard, Andrea Pavia-Jimenez, Weina Chen, Noelle S Williams, Harris Naina, Robert Collins, James Brugarolas, Jin Ye
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129233 (2015)
Doxorubicin has been shown to inhibit proliferation of cancer cells through proteolytic activation of CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor synthesized as a membrane-bound precursor. Upon doxorubicin treatme
Externí odkaz:
https://doaj.org/article/13d1229d141540a5b643ffc9d0a2992d
Autor:
Mehabaw G Derebe, Clare M Zlatkov, Sureka Gattu, Kelly A Ruhn, Shipra Vaishnava, Gretchen E Diehl, John B MacMillan, Noelle S Williams, Lora V Hooper
Publikováno v:
eLife, Vol 3 (2014)
Retinol plays a vital role in the immune response to infection, yet proteins that mediate retinol transport during infection have not been identified. Serum amyloid A (SAA) proteins are strongly induced in the liver by systemic infection and in the i
Externí odkaz:
https://doaj.org/article/3fbebc60fef6401a9e151b8eb1d0299c
Autor:
Yong Lu, Lin You, Liping Li, Jessica A. Kilgore, Shun Liu, Xiaoyu Wang, Yuanwei Dai, Qi Wei, Heping Shi, Lei Han, Lijun Sun, Zhijian J. Chen, Xuewu Zhang, Noelle S. Williams, Chuo Chen
Publikováno v:
ACS Central Science, Vol 9, Iss 12, Pp 2298-2305 (2023)
Externí odkaz:
https://doaj.org/article/2953af03e6d94562ad4941b50201775d
Autor:
Mahmoud S. Ahmed, Ayman B. Farag, Ian N. Boys, Ping Wang, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Jennifer L. Eitson, Maikke B. Ohlson, Wenchun Fan, Matthew B. McDougal, Katrina Mar, Suwannee Thet, Francisco Ortiz, Soo Young Kim, Ashley Solmonson, Noelle S. Williams, Andrew Lemoff, Ralph J. DeBerardinis, John W. Schoggins, Hesham A. Sadek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114614- (2023)
The continuing heavy toll of the COVID-19 pandemic necessitates development of therapeutic options. We adopted structure-based drug repurposing to screen FDA-approved drugs for inhibitory effects against main protease enzyme (Mpro) substrate-binding
Externí odkaz:
https://doaj.org/article/23a65e76569a486bbf633ca2ee9aedab
Autor:
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W. Boudreau, Lindsay E. Chatkewitz, Jessica A. Kilgore, Kashif Rafiq Zahid, Noelle S. Williams, Yaomin Chen, Shaohui Liu, Paul J. Hergenrother, Xiumei Huang
Publikováno v:
Cancers, Vol 15, Iss 24, p 5844 (2023)
Lung and breast cancers rank as two of the most common and lethal tumors, accounting for a substantial number of cancer-related deaths worldwide. While the past two decades have witnessed promising progress in tumor therapy, developing targeted tumor
Externí odkaz:
https://doaj.org/article/e68fc5c06b6b49fc825f9ed81528a168