Výsledky vyhledávání - "Noelle Leary"

Akademický článek

Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes

Autor: Noelle Leary, Sarina Walser, Yuliang He, Nikola Cousin, Paulo Pereira, Alessandro Gallo, Victor Collado‐Diaz, Cornelia Halin, Susana Garcia‐Silva, Hector Peinado, Lothar C. Dieterich

Publikováno v: Journal of Extracellular Vesicles, Vol 11, Iss 2, Pp n/a-n/a (2022)

Abstract Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of a pre‐metastatic niche. However, the signals leading to the

Externí odkaz: https://doaj.org/article/9ed222a2b5bb42e0a2c19f621003b1bf

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Isolation and Fluorescent Labeling of Extracellular Vesicles from Cultured Tumor Cells

Autor: Noelle, Leary, Sarina, Walser, Lothar C, Dieterich

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2504

Extracellular vesicles (EVs), comprising exosomes, ectosomes, and apoptotic bodies, are an important component of molecular cell-to-cell communication, and are critically involved in the pathophysiology of various diseases, including tumors. In order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f594d23931271f769dbffcc010d13348
https://pubmed.ncbi.nlm.nih.gov/35467288

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Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Autor: Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai

SummaryApolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e65379af953ea122df84bcbf9fcdeb2
https://doi.org/10.1101/2022.03.21.484146

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Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

Autor: Gwyneth Welch, Carles Boix, Eloi Schmauch, Jose Davila-Velderrain, Matheus B. Victor, Vishnu Dileep, Lorenzo Bozzelli, Qiao Su, Jemmie Cheng, Audrey Lee, Noelle Leary, Andreas Pfenning, Manolis Kellis, Li-Huei Tsai

DNA double strand breaks (DSBs) are linked to aging, neurodegeneration, and senescence1,2. However, the role played by neurons burdened with DSBs in disease-associated neuroinflammation is not well understood. Here, we isolate neurons harboring DSBs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f75198fd9deae4fd1c2934c9a6fef54
https://doi.org/10.1101/2021.12.23.474002

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Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons

Autor: Andreas Hierlemann, Giulio Zorzi, Noelle Leary, Marie Engelene J. Obien, Michele Fiscella

Publikováno v: Frontiers in Cellular Neuroscience
Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays

Poster Presentation & Abstract
Frontiers in Cellular Neuroscience
ISSN:1662-5102
Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed6d9d0b58daf5dae06ea2232d45efd

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