Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Noelle E. Huskey"'
Autor:
Noelle E. Huskey, Tingxia Guo, Kimberley J. Evason, Olga Momcilovic, David Pardo, Katelyn J. Creasman, Robert L. Judson, Robert Blelloch, Scott A. Oakes, Matthias Hebrok, Andrei Goga
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 374-389 (2015)
Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inh
Externí odkaz:
https://doaj.org/article/3a1e4906fb8c49fea99d78019f15620a
Autor:
François Kuonen, Ramon J. Whitson, Kerri E. Rieger, Gautam Shankar, Scott X. Atwood, Anthony E. Oro, Noelle E. Huskey, Prajakta D. Jaju, Kavita Y. Sarin
Publikováno v:
The Journal of investigative dermatology, vol 139, iss 7
J Invest Dermatol
J Invest Dermatol
Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive tumor responsiveness to Smoothened inhibitors (Smoi), resistance in advanced tumors remains c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd57a3c0456bcde9207581c8f382db3
https://escholarship.org/uc/item/8134c49f
https://escholarship.org/uc/item/8134c49f
Autor:
Brittany Anderton, Andrei Goga, Adam J. Dupuy, Jesse D. Riordan, Asha Balakrishnan, Kirk D. Jones, Mona Jodari, Holger Willenbring, David Brown, Raymond Ng, Guisheng Song, Lionel Lim, Aaron N. Chang, Xin Chen, Siu Tim Cheung, Noelle E. Huskey
Publikováno v:
Hepatology (Baltimore, Md.)
Hepatocellular carcinoma (HCC) is associated with poor survival for patients and few effective treatment options, raising the need for novel therapeutic strategies. MicroRNAs (miRNAs) play important roles in tumor development and show deregulated pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc9051f879ab32b14dc3db3b54e33ab
https://doi.org/10.1002/hep.26662
https://doi.org/10.1002/hep.26662
Autor:
Dai Horiuchi, Karl A. Merrick, Robert P. Fisher, Andrei Goga, Kevan M. Shokat, Chao Zhang, Lara Wohlbold, Noelle E. Huskey, Jasmina J. Allen
Publikováno v:
Molecular Cell. 42:624-636
Multiple cyclin-dependent kinases (CDKs) control eukaryotic cell division, but assigning specific functions to individual CDKs remains a challenge. During the mammalian cell cycle, Cdk2 forms active complexes before Cdk1, but lack of Cdk2 protein doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c283ffbce8a6e6461837da671db5726
https://doi.org/10.1016/j.molcel.2011.03.031
https://doi.org/10.1016/j.molcel.2011.03.031
Autor:
Peter Lengyel, Alex D. Shaw, Robert L. Judson, Akira Nguyen, Yuwei Phua, Thomas Preiss, Christopher S. Hackett, Robert Blelloch, Christopher S. Sullivan, Albert Chetcuti, Lionel Lim, Lesley J. Ashton, Asha Balakrishnan, William A. Weiss, Andrei Goga, Susan L. Woods, Noelle E. Huskey, Noelle D. L'Etoile, Yvan Chanthery, Murray D. Norris, Eric G. Marcusson, Alexander Swarbrick, Michelle Haber
Publikováno v:
Nature Medicine. 16:1134-1140
Inactivation of the p53 tumor suppressor pathway allows cell survival in times of stress and occurs in many human cancers; however, normal embryonic stem cells and some cancers such as neuroblastoma maintain wild-type human TP53 and mouse Trp53 (refe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07318eff677e5a602b8a3cd63bea02bf
https://doi.org/10.1038/nm.2227
https://doi.org/10.1038/nm.2227
Autor:
Stuart C. Feinstein, Sarah J. Benbow, Nichole E. LaPointe, Nicolette Dressler, Srinivasan Ramachandran, Thanh D. Do, Noelle E. Huskey, Megan Korff, Ratnesh Lal, Michelle R. Gaylord, H. Eric Feinstein, Michael T. Bowers, Kristi Lazar Cantrell, Nirav Patel, Brady Quon
Publikováno v:
Journal of neurochemistry. 137(6)
Despite extensive structure-function analyses, the molecular mechanisms of normal and pathological tau action remain poorly understood. How does the C-terminal microtubule-binding region regulate microtubule dynamics and bundling? In what biophysical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7a87a2dea0d271ee2d90abfd0a6ad4
https://pubmed.ncbi.nlm.nih.gov/26953146
https://pubmed.ncbi.nlm.nih.gov/26953146
Autor:
Eric S. Wang, Nichole A. Reyes, Scott A. Oakes, Noelle E. Huskey, Robert Blelloch, Collin Melton, Andrei Goga, Olga Momcilovic
Publikováno v:
Current biology : CB. 25(23)
The intrinsic (mitochondrial) apoptotic pathway is a conserved cell death program crucial for eliminating superfluous, damaged, or incorrectly specified cells [1], and the multi-domain pro-death BCL-2 family proteins BAX and BAK are required for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b51fab8e2f9292995bbe04454b956b3
https://pubmed.ncbi.nlm.nih.gov/26585277
https://pubmed.ncbi.nlm.nih.gov/26585277
Autor:
Noelle E. Huskey, Scott A. Oakes, Lionel Lim, Eric S. Wang, Morgan L. Truitt, John-Paul Upton, Michael T. McManus, Feroz R. Papa, Andrei Goga, Dan Han, Davide Ruggero, Likun Wang
Publikováno v:
Science (New York, N.Y.), vol 338, iss 6108
To Die For The unfolded protein response (UPR) adjusts the protein folding capacity of the endoplasmic reticulum (ER) to match demand. UPR signaling requires IRE1α, an ER transmembrane kinase-endoribonuclease (RNase) that becomes activated by unfold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254569fb9325a837c3da6c82f0791b99
https://escholarship.org/uc/item/87q1790v
https://escholarship.org/uc/item/87q1790v
Autor:
James W. Smyth, Dai Horiuchi, Gordon B. Mills, Sarah E. Davis, Andrei Goga, Katelyn J. Creasman, Noelle E. Huskey, Laura J. Esserman, Ana M. Gonzalez-Angulo, Alexey V. Bazarov, Marc E. Lenburg, Sanjay Chandriani, Paul Yaswen, Leonard Kusdra
Publikováno v:
Horiuchi, D; Kusdra, L; Huskey, NE; Chandriani, S; Lenburg, ME; Gonzalez-Angulo, AM; et al.(2012). MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. Journal of Experimental Medicine, 209(4), 679-696. doi: 10.1084/jem.20111512. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4q1317r7
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 209, iss 4
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 209, iss 4
Triple-negative breast cancers with elevated MYC are sensitized to CDK inhibition.
Estrogen, progesterone, and HER2 receptor-negative triple-negative breast cancers encompass the most clinically challenging subtype for which targeted therapeutic
Estrogen, progesterone, and HER2 receptor-negative triple-negative breast cancers encompass the most clinically challenging subtype for which targeted therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba562f9c23c97d32d96b0d9753cc40a4
http://www.escholarship.org/uc/item/4q1317r7
http://www.escholarship.org/uc/item/4q1317r7
Autor:
Noelle E. Huskey, Dai Horiuchi, LJ Esserman, Sarah E. Davis, Andrei Goga, Marc E. Lenburg, Gordon B. Mills, Ana M. Gonzalez-Angulo, S Chandriani, Katelyn J. Creasman, Leonard Kusdra
Publikováno v:
Cancer Research. 70:S5-4
Background: Breast cancer lacking the estrogen, progesterone and ERBB2 receptors, (“triple-negative”) encompasses an aggressive sub-type that is associated with a higher incidence of early tumor recurrence and poor patient outcome, particularly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03d530f2c8cbf4213513ed97c78203a
https://doi.org/10.1158/0008-5472.sabcs10-s5-4
https://doi.org/10.1158/0008-5472.sabcs10-s5-4