Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Noelle Dufour"'
Autor:
Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 259-276 (2017)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulat
Externí odkaz:
https://doaj.org/article/71c5f578d4f54a23910b98c544f67309
Autor:
Muhammad Qamar Saeed, Noelle Dufour, Cynthia Bartholmae, Urzula Sieranska, Malaika Knopf, Eloïse Thierry, Sylvain Thierry, Olivier Delelis, Nicolas Grandchamp, Héloïse Pilet, Philippe Ravassard, Julie Massonneau, Françoise Pflumio, Christof von Kalle, François Lachapelle, Alexis-Pierre Bemelmans, Manfred Schmidt, Ché Serguera
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes
Externí odkaz:
https://doaj.org/article/8f43f6c5cf2d499f95a79b299d2538d0
Autor:
Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106630- (2024)
Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) r
Externí odkaz:
https://doaj.org/article/014f66c687ef4b789460f73ea00cc84e
Autor:
Sueva Bernier, Alexis-Pierre Bemelmans, Noelle Dufour, Gilles Bonvento, Marie-Claude Gaillard, Géraldine Liot, Pauline Gipchtein, Noémie Cresto, Camille Gardier, Philippe Hantraye, Gwenaëlle Auregan, Nadja Van Camp, Daniela Molina, Caroline Jan, Martine Guillermier, Marie-Christine Chartier-Harlin, Francesco Gubinelli, Jean-Marc Taymans, Pauline Roost, Charlène Joséphine, Karine Cambon, Emmanuel Brouillet
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 6760, p 6760 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
International Journal of Molecular Sciences, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 6760, p 6760 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson’s disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e4f14cf397c9aa3340a960434da9ca
https://hal.science/hal-03452142
https://hal.science/hal-03452142
Autor:
Camille Gardier, Emmanuel Brouillet, Noémie Cresto, Gilles Bonvento, Martine Guillermier, Jean-Marc Taymans, Karine Cambon, Marie-Christine Chartier-Harlin, Charlène Joséphine, Géraldine Liot, Noelle Dufour, Nadja Van Camp, Alexis-Pierre Bemelmans, Sueva Bernier, Pauline Roost, Caroline Jan, Marie-Claude Gaillard, Pauline Gipstein, Daniela Molina, Philippe Hantraye, Gwenaelle Auregan, Francesco Gubinelli
Background: Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) likely play crucial roles both in sporadic and familial forms of Parkinson’s disease (PD). The most prevalent mutation in LRRK2 is the G2019S substitution, which induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6892095c35e9d3fc990954793c3b72
https://doi.org/10.21203/rs.3.rs-24218/v1
https://doi.org/10.21203/rs.3.rs-24218/v1
Autor:
Martine Guillermier, Marie-Claude Gaillard, Géraldine Liot, Déborah Bellet, Gwenaëlle Auregan, Elsa Diguet, Nicole Déglon, Noelle Dufour, Philippe Hantraye, Francesco Gubinelli, Julien Mitja, Karine Cambon, Noémie Cresto, Emmanuel Brouillet, Charlène Joséphine, Alain Joliot, Camille Gardier, Caroline Jan, Gilles Bonvento, Laurine Legroux, Alexis-Pierre Bemelmans
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Neurobiology of Disease, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
Neurobiology of Disease, Elsevier, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Neurobiology of Disease, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
International audience; The G2019S substitution in the kinase domain of LRRK2 (LRRK2 G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2 G2019S are thought to result from an increase in its kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24321246af441b617fd04891e482496
https://hal.archives-ouvertes.fr/hal-03043360/document
https://hal.archives-ouvertes.fr/hal-03043360/document
Autor:
María Angeles Carrillo-de Sauvage, Lucile Ben Haim, Gilles Bonvento, Laurene Abjean, Mylène Gaudin, Alexis Bemelmans, Fanny Petit, Jean-François Deleuze, Robert Olaso, Anne-Sophie Hérard, Sueva Bernier, Céline Derbois, Martine Guillermier, Carole Escartin, Noelle Dufour, Philippe Hantraye, Emmanuel Brouillet, Pauline Gipstein
Publikováno v:
Pathogenic mechanisms.
Astrocytes are essential partners for neurons and their role in Huntington’s disease (HD) is emerging. In HD, astrocytes change and become reactive. Astrocyte reactivity is characterized by morphological changes but its functional impact is still u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9dd52a00f54729813cb20a7525ffa33
https://doi.org/10.1136/jnnp-2018-ehdn.40
https://doi.org/10.1136/jnnp-2018-ehdn.40
Autor:
Nicolas Merienne, Noelle Dufour, A Viret, Philippe Hantraye, Maria Rey, Nicole Déglon, A Delzor
Publikováno v:
Gene Therapy, vol. 22, no. 10, pp. 830-839
Gene Ther.
Gene Ther.
Cell-type-specific gene silencing is critical to understand cell functions in normal and pathological conditions, in particular in the brain where strong cellular heterogeneity exists. Molecular engineering of lentiviral vectors has been widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15bc93a9a0b512270a3986e05f5a164
https://doi.org/10.1038/gt.2015.54
https://doi.org/10.1038/gt.2015.54
Autor:
Maria C. Pedroso de Lima, Luís Pereira de Almeida, Sandro Alves, Gwennaelle Auregan, Nicole Déglon, Raymonde Hassig, Clévio Nóbrega, Emmanuel Brouillet, Noelle Dufour, Philippe Hantraye, Isabel Nascimento-Ferreira
Publikováno v:
Human Molecular Genetics. 19:2380-2394
Machado-Joseph disease or spinocerebellar ataxia type 3 (MJD/SCA3) is a fatal, autosomal dominant disorder caused by a cytosine-adenine-guanine expansion in the coding region of the MJD1 gene. RNA interference has potential as a therapeutic approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ccef661e8ec602396674817912db20
https://doi.org/10.1093/hmg/ddq111
https://doi.org/10.1093/hmg/ddq111
Autor:
Jinho Kim, Mackenzie Welch, Robert J. Ferrante, Emmanuel Brouillet, Noelle Dufour, Philippe Hantraye, Nicole Déglon, Richard Gilmore, Gilles Bonvento, Mathilde Faideau, Kerry Cormier, Martine Guillermier, Gwennaelle Auregan
Publikováno v:
Human Molecular Genetics; Vol 19
Human Molecular Genetics
Human Molecular Genetics
Huntington's disease (HD) is a neurodegenerative disorder previously thought to be of primary neuronal origin, despite ubiquitous expression of mutant huntingtin (mHtt). We tested the hypothesis that mHtt expressed in astrocytes may contribute to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcf1040b7e98a816c45f2ed0d45e10e