Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

Autor: Alicia López, Noelia Aparicio, M. Ruth Pazos, M. Teresa Grande, M. Asunción Barreda-Manso, Irene Benito-Cuesta, Carmen Vázquez, Mario Amores, Gonzalo Ruiz-Pérez, Elena García-García, Margaret Beatka, Rosa M. Tolón, Bonnie N. Dittel, Cecilia J. Hillard, Julián Romero

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)

Abstract Background Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially relevant in the context

Externí odkaz: https://doaj.org/article/1c0c192ba5124243a8c6c06f7122bce8

Supplementary Figures 1 - 6, Table 1, Methods from Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38γ and p38δ, Linking Inflammation and Cancer in Colitis-Associated Colon Cancer

Autor: Ana Cuenda, Jose Montans, Elena Collantes, Marian Fernandez-Estévez, Rafal Zur, Noelia Aparicio, Ana Risco, Ma Isabel Cerezo-Guisado, Alejandra Escós, Dayanira Alsina-Beauchamp, Paloma del Reino

Figure S1. Effect of p38gamma and p38delta deletion in early stages of colitis-associated colon cancer induced by AOM/DSS treatment. Figure S2. p38gamma and p38deltaexpression in AOM/DSS-treated and untreated mouse colon. WT, p38gamma /-, p38delta/-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586caa926e6c1c8817548c83fbcfa835
https://doi.org/10.1158/0008-5472.22403426.v1

Myeloid cell deficiency of p38 gamma/p38 delta protects against candidiasis and regulates antifungal immunity

Autor: Pilar Fajardo, Susana Alemany, Alejandra Escós, Mihai G. Netea, Dayanira Alsina-Beauchamp, Juan Jose Sanz-Ezquerro, Carlos del Fresno, Jorge Domínguez-Andrés, Noelia Aparicio, Natalia Shpiro, Diego Gonzalez‐Romero, Ana Cuenda, Miguel A. Martín-Serrano, Ana Risco, Carlos Ardavín, Ester Díaz-Mora, Rafal Zur, Gordon D. Brown

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
EMBO Molecular Medicine, 10, 5, pp.
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 5, Pp n/a-n/a (2018)
EMBO Molecular Medicine, 10,
Digital.CSIC. Repositorio Institucional del CSIC
instname

Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a235f86e70e7cd6bb71d9e5162e1893
http://hdl.handle.net/20.500.12105/6673

Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer

Autor: Dayanira Alsina-Beauchamp, Rafal Zur, Jose Montans, Alejandra Escós, Ana Cuenda, Ana Risco, Paloma del Reino, Elena Collantes, Ma Isabel Cerezo-Guisado, Marian Fernandez-Estevez, Noelia Aparicio

Publikováno v: Cancer research. 74(21)

p38 MAPK signaling has been implicated in the regulation of processes leading to cancer development and progression. Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of this association remains largely unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356c7dc2d271a67e6d0e31cacb7f7cca
https://pubmed.ncbi.nlm.nih.gov/25217523