Výsledky vyhledávání - "Noele Certain"

Akademický článek

Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

Autor: Kelvin Chan, Jacquelyn Nestor, Tomás S. Huerta, Noele Certain, Gabrielle Moody, Czeslawa Kowal, Patricio T. Huerta, Bruce T. Volpe, Betty Diamond, Lonnie P. Wollmuth

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample

Externí odkaz: https://doaj.org/article/a8fc9079fa874a23beb127b18897c7a5

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Differential regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) receptor tetramerization by auxiliary subunits

Autor: Noele Certain, Quan Gan, Joseph Bennett, Helen Hsieh, Lonnie P. Wollmuth

Publikováno v: bioRxiv

AMPA receptor (AMPAR) auxiliary subunits are specialized, non-transient binding partners of AMPARs that modulate their ion channel gating properties and pharmacology, as well as their biogenesis and trafficking. The most well characterized families o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2ea87be949fb2616d564b567e0050
https://europepmc.org/articles/PMC9934675/

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Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

Autor: Patricio T. Huerta, Bruce T. Volpe, Lonnie P. Wollmuth, Czeslawa Kowal, Kelvin Chan, Noele Certain, Gabrielle Moody, Betty Diamond, Tomás S. Huerta, Jacquelyn Nestor

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications

Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of autoantibodies (DNRAbs) cross-react with the GluN2A and GluN2B subunits of the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883c28bb5a38918fae5c3537ef5f9856
https://doaj.org/article/a8fc9079fa874a23beb127b18897c7a5

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NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity

Autor: Johansen B. Amin, Noele Certain, Miaomiao He, Lonnie P. Wollmuth, Aaron Gochman

NMDA receptors (NMDAR) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission in the nervous system. A central feature of NMDAR physiology is the opening of the ion channel driven by presynaptically-releas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4c539960370feec877ddc7670f45fb
https://doi.org/10.1101/2020.06.09.142687

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Lupus auto-antibodies act as positive allosteric modulators at NMDA receptors and induce spatial memory deficits

Autor: Patricio T. Huerta, Gabrielle Moody, Bruce T. Volpe, Jacquelyn Nestor, Lonnie P. Wollmuth, Czeslawa Kowal, Betty Diamond, Kelvin Chan, Tomás S. Huerta, Noele Certain

Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of auto-antibodies (DNRAbs) cross-react with the GluN2A and GluN2B subunits of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db2e8ded8408a3d0cb03a9614a36154

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