Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Noel Yan-Ki Chan"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:97-105
During myocardial ischemia/reperfusion, lipid peroxidation leads to the formation of toxic aldehydes that contribute to ischemic dysfunction. Mitochondrial aldehyde dehydrogenase type 2 (ALDH2) alleviates ischemic heart damage and reperfusion arrhyth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9068b66d2618342e1ef87efcb88d7540
https://doi.org/10.1124/jpet.112.196626
https://doi.org/10.1124/jpet.112.196626
Publikováno v:
Circulation. 125:298-307
Background— Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with recombinant brain natriuretic peptide (nesiritide) failed to prove it. Unsuspected proadrenergic effects might oppose the anticipated bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f27ee8e2621bb47faa6b4b38e9cb35b
https://doi.org/10.1161/circulationaha.111.059097
https://doi.org/10.1161/circulationaha.111.059097
Publikováno v:
Journal of Medicinal Chemistry. 50:6458-6461
A new two-step methodology achieves stereoselective synthesis of beta-nicotinamide riboside and a series of related amide, ester, and acid nucleosides. Compounds were prepared through a triacetylated-nicotinate ester nucleoside, via coupling of eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38addc356925f266e3cc367d37cd0502
https://doi.org/10.1021/jm701001c
https://doi.org/10.1021/jm701001c
Autor:
Roberto Levi, Mariselis Salazar-Rodriguez, Silvia Aldi, Alice Marino, Noel Yan-Ki Chan, Kengo Tomita, Kenichiro Koda, Robin L. Thurmond, Ken-ichi Takano
Publikováno v:
The Journal of pharmacology and experimental therapeutics, Vol. 349, no.3, p. 508-17 (2014)
Renin released by ischemia/reperfusion (I/R) from cardiac mast cells (MCs) activates a local renin-angiotensin system (RAS) causing arrhythmic dysfunction. Ischemic preconditioning (IPC) inhibits MC renin release and consequent activation of this loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8915483efd12edefe9301c4d78a022
https://pubmed.ncbi.nlm.nih.gov/24696042
https://pubmed.ncbi.nlm.nih.gov/24696042
Autor:
Emily Mangano, Maria Cimini, Chiara Mangiaracina, Polina Goichberg, Ada Pesapane, Emeka Ifedigbo, Giulia Borghetti, Andrea Sorrentino, Kazuya Isobe, Mario Ricciardi, Sergio Signore, Anna Czarna, Toru Hosoda, Marcello Rota, Junghyun Kim, Ewa Wybieralska, Augustine M.K. Choi, Annarosa Leri, Donato Cappetta, Piero Anversa, Noel Yan-Ki Chan, Fumihiro Sanada, Barbara Ogorek, Jan Kajstura, Mark A. Perrella
Rationale: Hypoxia favors stem cell quiescence, whereas normoxia is required for stem cell activation, but whether cardiac stem cell (CSC) function is regulated by the hypoxic/normoxic state of the cell is currently unknown. Objective: A balance betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b56d8d1de69e89d972bfafb78d3fe6
http://hdl.handle.net/11585/630889
http://hdl.handle.net/11585/630889
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 343(3)
We reported previously that natriuretic peptides, including brain natriuretic peptide (BNP), promote norepinephrine release from cardiac sympathetic nerves and dopamine release from differentiated pheochromocytoma PC12 cells. These proexocytotic effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da0aed0969a622b7af91f08f53acaaa
https://pubmed.ncbi.nlm.nih.gov/22923736
https://pubmed.ncbi.nlm.nih.gov/22923736
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 340(1)
In severe myocardial ischemia, histamine 3 (H₃) receptor activation affords cardioprotection by preventing excessive norepinephrine release and arrhythmias; pivotal to this action is the inhibition of neuronal Na⁺/H⁺ exchanger (NHE). Conversely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d371b002d89ac5ee8fc5ddf3919a240
https://pubmed.ncbi.nlm.nih.gov/22011436
https://pubmed.ncbi.nlm.nih.gov/22011436
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d9fcdd921deeb9eee5344c0ddeda601
https://doi.org/10.1096/fasebj.25.1_supplement.1085.14
https://doi.org/10.1096/fasebj.25.1_supplement.1085.14
Autor:
Racha Estephan, Kenichiro Koda, Federico Corti, Randi B. Silver, Daria Mochly-Rosen, Noel Yan-Ki Chan, Roberto Levi, Mariselis Salazar-Rodriguez
Publikováno v:
Circulation. 122(8)
Background— Renin released by ischemia/reperfusion from cardiac mast cells activates a local renin-angiotensin system (RAS). This exacerbates norepinephrine release and reperfusion arrhythmias (ventricular tachycardia and fibrillation), making RAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6305b9c3bf556f9e0f23ebfc3f6bf3
https://pubmed.ncbi.nlm.nih.gov/20697024
https://pubmed.ncbi.nlm.nih.gov/20697024
Publikováno v:
The FASEB Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a7f5135881315c0c45b69ee7b3ba1e
https://doi.org/10.1096/fasebj.24.1_supplement.lb521
https://doi.org/10.1096/fasebj.24.1_supplement.lb521