Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Noel T. Southall"'
Autor:
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander I. Agoulnik
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Externí odkaz:
https://doaj.org/article/50c86baebeb04e3ebabf87beea0be0a0
Autor:
Pranav Shah, Vishal B. Siramshetty, Alexey V. Zakharov, Noel T. Southall, Xin Xu, Dac-Trung Nguyen
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-14 (2020)
Abstract Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the con
Externí odkaz:
https://doaj.org/article/1625cd47c9774f6a95d3d18250ef445d
Autor:
Amy E. Moritz, Nora S. Madaras, Laura R. Inbody, Amber M. Kelley, Disha M. Gandhi, Emmanuel O. Akano, Kuo H. Lee, R. Benjamin Free, Xin Hu, Noel T. Southall, Marc Ferrer, Lei Shi, Kevin J. Frankowski, David R. Sibley
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448763b860a4bf69bb423d98f6b99d0c
https://doi.org/10.1124/jpet.122.157730
https://doi.org/10.1124/jpet.122.157730
Autor:
Heide L. Ford, Rui Zhao, Juan Marugan, Samarjit Patnaik, James C. Costello, Angelo D'Alessandro, Daniel P. Regan, Daniel L. Gustafson, Marc Ferrer, Noel T. Southall, Xin Hu, Elena Barnaeva, Rebecca King, Lesley Mathews Griner, Jennyvette Trinidad-Pineiro, Lingdi Zhang, Dominique Ramirez, Michael U.J. Oliphant, Rachel Culp-Hill, Andrew Goodspeed, Matthew D. Galbraith, Deguang Kong, Jessica Y. Hsu, Melanie A. Blevins, Hengbo Zhou
Figure legends for all supplemental figures (1-6) describe key findings and experimental details.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275308f4b57166bf818bdb7c67c3ac5c
https://doi.org/10.1158/0008-5472.22425861.v1
https://doi.org/10.1158/0008-5472.22425861.v1
Autor:
Heide L. Ford, Rui Zhao, Juan Marugan, Samarjit Patnaik, James C. Costello, Angelo D'Alessandro, Daniel P. Regan, Daniel L. Gustafson, Marc Ferrer, Noel T. Southall, Xin Hu, Elena Barnaeva, Rebecca King, Lesley Mathews Griner, Jennyvette Trinidad-Pineiro, Lingdi Zhang, Dominique Ramirez, Michael U.J. Oliphant, Rachel Culp-Hill, Andrew Goodspeed, Matthew D. Galbraith, Deguang Kong, Jessica Y. Hsu, Melanie A. Blevins, Hengbo Zhou
Detailed information (source and working dilution) of antibodies have been used for WB, ICC and IHC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25de09a68bb66dbdf790bf8c9764742a
https://doi.org/10.1158/0008-5472.22425852.v1
https://doi.org/10.1158/0008-5472.22425852.v1
Autor:
Heide L. Ford, Rui Zhao, Juan Marugan, Samarjit Patnaik, James C. Costello, Angelo D'Alessandro, Daniel P. Regan, Daniel L. Gustafson, Marc Ferrer, Noel T. Southall, Xin Hu, Elena Barnaeva, Rebecca King, Lesley Mathews Griner, Jennyvette Trinidad-Pineiro, Lingdi Zhang, Dominique Ramirez, Michael U.J. Oliphant, Rachel Culp-Hill, Andrew Goodspeed, Matthew D. Galbraith, Deguang Kong, Jessica Y. Hsu, Melanie A. Blevins, Hengbo Zhou
Detailed description of methods used for compound 8430 synthesis, cell culture and compound 8430 pharmacokinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f07d1d2ca0a85d209aa2b5b5b29b9d
https://doi.org/10.1158/0008-5472.22425855.v1
https://doi.org/10.1158/0008-5472.22425855.v1
Autor:
Heide L. Ford, Rui Zhao, Juan Marugan, Samarjit Patnaik, James C. Costello, Angelo D'Alessandro, Daniel P. Regan, Daniel L. Gustafson, Marc Ferrer, Noel T. Southall, Xin Hu, Elena Barnaeva, Rebecca King, Lesley Mathews Griner, Jennyvette Trinidad-Pineiro, Lingdi Zhang, Dominique Ramirez, Michael U.J. Oliphant, Rachel Culp-Hill, Andrew Goodspeed, Matthew D. Galbraith, Deguang Kong, Jessica Y. Hsu, Melanie A. Blevins, Hengbo Zhou
Supplemental figures (1-6) demonstrate the efficacy of parental SIX1/EYA2 inhibitor, synthesis of compound 8430, endogenous SIX1 and EYA2 expression in tumor lines, as well as 8430's transcriptional impact, pharmacokinetic/toxicity and effect on meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4f0e342d3f567d958d9477fbdd8ef2
https://doi.org/10.1158/0008-5472.22425858
https://doi.org/10.1158/0008-5472.22425858
Autor:
Heide L. Ford, Rui Zhao, Juan Marugan, Samarjit Patnaik, James C. Costello, Angelo D'Alessandro, Daniel P. Regan, Daniel L. Gustafson, Marc Ferrer, Noel T. Southall, Xin Hu, Elena Barnaeva, Rebecca King, Lesley Mathews Griner, Jennyvette Trinidad-Pineiro, Lingdi Zhang, Dominique Ramirez, Michael U.J. Oliphant, Rachel Culp-Hill, Andrew Goodspeed, Matthew D. Galbraith, Deguang Kong, Jessica Y. Hsu, Melanie A. Blevins, Hengbo Zhou
Metastasis is the major cause of mortality for patients with cancer, and dysregulation of developmental signaling pathways can significantly contribute to the metastatic process. The Sine oculis homeobox homolog 1 (SIX1)/eyes absent (EYA) transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086bfbf3d1139106f6a56744dba674a1
https://doi.org/10.1158/0008-5472.c.6512157.v1
https://doi.org/10.1158/0008-5472.c.6512157.v1
Autor:
Amy E. Moritz, Nora S. Madaras, Laura R. Inbody, Amber M. Kelley, Disha M. Gandhi, Emmanuel Akano, Kuo H. Lee, R. B. Free, Xin Hu, Noel T. Southall, Marc Ferrer, Lei Shi, Kevin J. Frankowski, David R. Sibley
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2972247ea3513a2331f1885f0f03c996
https://doi.org/10.1096/fasebj.2022.36.s1.r2589
https://doi.org/10.1096/fasebj.2022.36.s1.r2589
Autor:
Noel T. Southall† and, Ken A. Dill
Publikováno v:
The Journal of Physical Chemistry B. 104:1326-1331
We model the aqueous solvation of a nonpolar solute as a function of its radius. We use a simplified statistical mechanical model of water, the Mercedes Benz (MB) model, in NPT Monte Carlo simulations. This model has previously been shown to predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284608dd927f13a323209803e0046cbc
https://doi.org/10.1021/jp992860b
https://doi.org/10.1021/jp992860b