Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Noel J Buckley"'
Autor:
Haiwei Zhang, Hongchen Li, Mingshun Lu, Shengnan Wang, Xueya Ma, Fei Wang, Jiaxi Liu, Xinyu Li, Haichao Yang, Fan Zhang, Haitao Shen, Noel J Buckley, Nikita Gamper, Ebenezer N Yamoah, Ping Lv
Publikováno v:
eLife, Vol 11 (2022)
Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that recognizes neuron-restrictive silencer elements in the mammalian genomes in a tissue- and cell-specific manner. The identity of REST target genes and molecu
Externí odkaz:
https://doaj.org/article/210f4196a7c74ead814971fb88884f77
Autor:
Rory Johnson, Christina Hui-leng Teh, Galih Kunarso, Kee Yew Wong, Gopalan Srinivasan, Megan L Cooper, Manuela Volta, Sarah Su-ling Chan, Leonard Lipovich, Steven M Pollard, R Krishna Murthy Karuturi, Chia-lin Wei, Noel J Buckley, Lawrence W Stanton
Publikováno v:
PLoS Biology, Vol 6, Iss 10, p e256 (2008)
The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcripti
Externí odkaz:
https://doaj.org/article/e24afa92417843969992a6d00db34686
Autor:
Yuh-Man Sun, Megan Cooper, Sophie Finch, Hsuan-Hwai Lin, Zhou-Feng Chen, Brenda P Williams, Noel J Buckley
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3656 (2008)
Neural development from blastocysts is strictly controlled by intricate transcriptional programmes that initiate the down-regulation of pluripotent genes, Oct4, Nanog and Rex1 in blastocysts followed by up-regulation of lineage-specific genes as neur
Externí odkaz:
https://doaj.org/article/4fb978f5b30f476b8c86b148e86d9844
Autor:
Shakti Gupta, Lucia Dutan Polit, Michael Fitzgerald, Helen A. Rowland, Divya Murali, Noel J. Buckley, Shankar Subramaniam
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionNeural induction of human induced pluripotent stem cells represents a critical switch in cell state during which pluripotency is lost and commitment to a neural lineage is initiated. Although many of the key transcription factors involved
Externí odkaz:
https://doaj.org/article/a30239e08ad74ede8fa328bc18a09c36
Autor:
Yuting Zhang, Upamanyu Ghose, Noel J. Buckley, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Lars Bertram, Simon Lovestone, Alejo J. Nevado-Holgado, Liu Shi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Background and objectiveBlood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential bio
Externí odkaz:
https://doaj.org/article/b37fc55ae6b040a88cecc56e7dd0a6f8
Autor:
Liu Shi, Colin R. Buchanan, Simon R. Cox, Robert F. Hillary, Riccardo E. Marioni, Archie Campbell, Caroline Hayward, Aleks Stolicyn, Heather C. Whalley, Mathew A. Harris, Jennifer Waymont, Gordon Waiter, Ellen Backhouse, Joanna M. Wardlaw, Douglas Steele, Andrew Mcintosh, Simon Lovestone, Noel J. Buckley, Alejo J. Nevado‐Holgado
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction This study aims to first discover plasma proteomic biomarkers relating to neurodegeneration (N) and vascular (V) damage in cognitively normal individuals and second to discover proteins mediating sex‐related difference in N an
Externí odkaz:
https://doaj.org/article/dc204ff9c6c74337954d2be2ac597762
Autor:
Jurgen Wess, Celine Valant, Andrew B. Tobin, David Thal, Roy D. Schwarz, Neil M. Nathanson, Ernst Mutschler, Fred Mitchelson, Chris Langmead, Günter Lambrecht, Heinz J. Kilbinger, Rudolf Hammer, Christian C. Felder, Frederick Ehlert, Richard M. Eglen, Arthur Christopoulos, R.A. John Challiss, Noel J. Buckley, David A. Brown, Sophie Bradley, Nigel J. M. Birdsall
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Autor:
Alicia Gómez-Pascual, Talel Naccache, Jin Xu, Koroush Hooshmand, Asger Wretlind, Martina Gabrielli, Marta Tiffany Lombardo, Liu Shi, Noel J. Buckley, Betty M. Tijms, Stephanie J. B. Vos, Mara ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Pop, Pablo Martinez-Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J. Nevado-Holgado, Petroula Proitsi, Claudia Verderio, Juan A. Botía, Cristina Legido-Quigley
Mild Cognitive Impairment (MCI) is a phase that can precede Alzheimer's Disease (AD). To better understand the molecular mechanisms underlying conversion from MCI to AD, we proposed a multiomics machine learning pipeline (four algorithms) to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7029d5eb866c304ac63275859d5c15
https://doi.org/10.1101/2023.03.02.23286674
https://doi.org/10.1101/2023.03.02.23286674
Autor:
Liu Shi, Jin Xu, Rebecca Green, Asger Wretlind, Jan Homann, Noel J. Buckley, Betty M. Tijms, Stephanie J. B. Vos, Christina M. Lill, Mara ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez‐Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J. Nevado‐Holgado, Petroula Proitsi, Cristina Legido‐Quigley
Publikováno v:
Alzheimer's & Dementia. Elsevier Science
Alzheimer's and Dementia. Elsevier
Shi, L, Xu, J, Green, R, Wretlind, A, Homann, J, Buckley, N J, Tijms, B M, Vos, S J B, Lill, C M, Kate, M T, Engelborghs, S, Sleegers, K, Frisoni, G B, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Streffer, J, Barkhof, F, Zetterberg, H, Visser, P J, Lovestone, S, Bertram, L, Nevado-Holgado, A J, Proitsi, P & Legido-Quigley, C 2023, ' Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12961
Alzheimer's & dementia
Alzheimer's and Dementia. Elsevier
Shi, L, Xu, J, Green, R, Wretlind, A, Homann, J, Buckley, N J, Tijms, B M, Vos, S J B, Lill, C M, Kate, M T, Engelborghs, S, Sleegers, K, Frisoni, G B, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Streffer, J, Barkhof, F, Zetterberg, H, Visser, P J, Lovestone, S, Bertram, L, Nevado-Holgado, A J, Proitsi, P & Legido-Quigley, C 2023, ' Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12961
Alzheimer's & dementia
IntroductionThis study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disea
Autor:
Sarah M. Goodday, Alejo J. Nevado-Holgado, Danielle Newby, Marco Fernandes, Noel J. Buckley, Laura Winchester, William Sproviero, Albert Prats-Uribe, Daniel Prieto Alhambra, Liu Shi
Publikováno v:
Biological Psychiatry. 89:817-824
Background Findings from randomized controlled trials have yielded conflicting results on the association between blood pressure (BP) and dementia traits. We tested the hypothesis that a causal relationship exists between systolic BP (SBP) and/or dia