Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Noel Horgan"'
Autor:
Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, Alberto Villanueva, Breandán N. Kennedy
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
Uveal melanoma (UM) is an intraocular cancer with propensity for liver metastases. The median overall survival (OS) for metastatic UM (MUM) is 1.07 years, with a reported range of 0.84–1.34. In primary UM, high cysteinyl leukotriene receptor 1 (Cys
Externí odkaz:
https://doaj.org/article/eac8866d1abb4c86aceb6f7196a8a3cd
Autor:
Charlotte Andrieu, Niamh McNamee, Anne-Marie Larkin, Alanna Maguire, Roopika Menon, Judith Mueller-Eisert, Noel Horgan, Susan Kennedy, Giuseppe Gullo, John Crown, Naomi Walsh
Publikováno v:
Medical Sciences, Vol 10, Iss 2, p 26 (2022)
Molecular and histopathological analysis of melanoma subtypes has revealed distinct epidemiological, genetic, and clinical features. However, immunotherapy for advanced metastatic melanoma patients does not differ based on subtype. Response to immune
Externí odkaz:
https://doaj.org/article/3453e78c93ba4a72b2f1c7a5332b0f8d
Publikováno v:
Case Reports in Oncological Medicine, Vol 2016 (2016)
Thyroid metastasis is a rare occurrence with cutaneous melanoma and even more uncommon with uveal melanoma. The management of such metastasis is uncertain due to its infrequency and, in the era of immunotherapy, the effect of these novel drugs on unc
Externí odkaz:
https://doaj.org/article/0520a8426b7c402f836626a786b9a6b1
Publikováno v:
Irish Journal of Medical Science (1971 -).
Aim We aim to evaluate the impact of the COVID-19 pandemic on ocular oncology in Ireland, comparing uveal melanoma trends in 2019 to 2020. Methods Patients included for analysis were those that presented to the ocular oncology service from January 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::288b65d223783f0aa56127899dd5a935
https://doi.org/10.1007/s11845-023-03310-z
https://doi.org/10.1007/s11845-023-03310-z
Autor:
Noel Horgan, Annett Linge, M. Clynes, Pathma Ramasamy, Paula Meleady, Anne-Marie Larkin, Stephen Beatty, Fionnuala McAree, Paul Moriarty, Conor Murphy, Susan Kennedy, Damien Tiernan
Publikováno v:
Journal of Clinical Pathology. 73:408-412
AimsUveal melanoma (UM) is the most common primary intraocular malignancy in adults, and 40% develop fatal metastatic disease. Overexpression of thioredoxin-dependent peroxidase reductase (PRDX3) has been implicated in several cancers, including pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9098765cea90f5954a9882a9634267a8
https://doi.org/10.1136/jclinpath-2019-206173
https://doi.org/10.1136/jclinpath-2019-206173
Autor:
Grace Mealy, Naomi Walsh, Caoimhe Goldrick, Letizia Palanga, Bobby Tang, Noel Horgan, John Crown, Susan Kennedy
Publikováno v:
Journal of Cancer
The molecular, histopathological, genomic and transcriptomic characteristics of uveal melanoma (UM) have identified four molecular subgroups with different clinical outcomes. Despite the improvements in UM classification and biological pathology, cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be5ebe205f2d8c45f5c183dc333bd22
https://pubmed.ncbi.nlm.nih.gov/34149931
https://pubmed.ncbi.nlm.nih.gov/34149931
Autor:
Giuseppe Gullo, Susan Kennedy, Noel Horgan, Paul M. Walsh, Valerie O'Neill, Moya Cunningham, Sandra Deady, Caroline Baily, Mary Dunne
Publikováno v:
Ocular Oncology and Pathology. 5:195-204
Purpose: To report the clinical features and epidemiology of uveal melanoma in Ireland. Methods: This was an observational study of 253 patients with a new diagnosis of uveal melanoma between June 2010 and December 2015. Main outcome measures include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3784c1c0b5cc8fa5fa5348e7c32f67a6
https://doi.org/10.1159/000492391
https://doi.org/10.1159/000492391
Publikováno v:
Ophthalmology. 128:1707
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a682f3013da00c1f45860f7bc1f7d58
https://doi.org/10.1016/j.ophtha.2021.04.023
https://doi.org/10.1016/j.ophtha.2021.04.023
Autor:
Tadhg Reddan, John Crown, Susan Kennedy, Aileen O'Meara, Fergus Keane, Cha Len Lee, Valerie O'Neill, Giuseppe Gullo, Helen Craig, Noel Horgan, Deirdre Smith, Emer Lynch, Naomi Walsh
Publikováno v:
Journal of Clinical Oncology. 39:e21585-e21585
e21585 Background: The treatment of MUM remains highly unsatisfactory. Single agent ICI produce low response rates. Two recent phase II trials of combination Ipilimumab and Nivolumab yielded response rates of 12% and 18%. We report the long-term surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6fe1c368a75231cd5bc1a4d827bf81d
https://doi.org/10.1200/jco.2021.39.15_suppl.e21585
https://doi.org/10.1200/jco.2021.39.15_suppl.e21585
Autor:
Noel Horgan, Damien Tiernan, Paula Meleady, Stephen Beatty, Paul Moriarty, Susan Kennedy, Conor Murphy, Martin Clynes, Pathma Ramasamy
Publikováno v:
Experimental Eye Research. 118:1-12
Uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence of 5-7 per million per year. It is associated with the development of metastasis in about 50% of cases, and 40% of patients with uveal melanoma die of metas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388879999e1f036c59d3603991f19755
https://doi.org/10.1016/j.exer.2013.09.005
https://doi.org/10.1016/j.exer.2013.09.005