Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Noel G. Harvey"'
Autor:
Laurence J. Hirsch, Diane E. Sutter, Leszek Nosek, Lutz Heinemann, Heinz-Joerg Kurth, Christoph Kapitza, Noel G. Harvey, Ulrike Hövelmann, Ronald J. Pettis
Publikováno v:
Diabetes Technology & Therapeutics. 13:443-450
This study assessed pharmacokinetics (PK) and pharmacodynamic postprandial glycemia (PPG) in patients with type 1 diabetes mellitus (T1DM) after a standardized liquid meal following insulin lispro (IL) or regular human insulin (RHI) given by micronee
Autor:
Stephane Bonnet, John A. Mikszta, Philippe Emile Fernand Laurent, Paul G. Alchas, Noel G. Harvey, Ronald J. Pettis, Paulina Regolini
Publikováno v:
Vaccine. 25:8833-8842
The advantages of intradermal (ID) vaccine administration have been well documented but difficulties in performing ID vaccination using existing techniques and equipment have limited it's clinical application. In the present study, a new ID injection
Autor:
John M. Brittingham, Joanne Huang, John P. Dekker, Beverly Dyas, John A. Mikszta, Chad J. Roy, Robert G. Ulrich, Vincent J. Sullivan, Cheryl H. Dean, Noel G. Harvey
Publikováno v:
Infection and Immunity. 74:6806-6810
The recombinant protective antigen (rPA) of Bacillus anthracis is a promising anthrax vaccine. We compared serum immunoglobulin G levels and toxin-neutralizing antibody titers in rabbits following delivery of various doses of vaccine by microneedle-b
Autor:
Wendy D. Woodley, Matthew S. Ferriter, Duane T. Brandau, Robert G. Ulrich, John A. Mikszta, C. Russell Middaugh, Noel G. Harvey, Ge Jiang, C. Robin Hwang, Kevin D. Mar, Sangeeta B. Joshi, Vincent J. Sullivan, Laura J. Peek, Juan Huang, Brandi Ford
Publikováno v:
Journal of Pharmaceutical Sciences. 95:80-96
Anthrax remainsaseriousthreatworldwideas abioterroragent. Asecond- generationanthraxvaccinecurrentlyunderclinicalevaluationconsistsofarecombinant Protective Antigen (rPA) of Bacillus anthracis. We have previously demonstrated that complete protection
Autor:
Ronald J. Pettis, Diane E. Sutter, John A. Mikszta, Jason B. Alarcon, John M. Brittingham, Noel G. Harvey
Publikováno v:
Nature Medicine. 8:415-419
Skin is an attractive target for delivery of genetic therapies and vaccines. However, new approaches are needed to access this tissue more effectively. Here, we describe a new delivery technology based on arrays of structurally precise, micron-scale
Autor:
Carl R. Delsorbo, Richard J. Spontak, Jonathan L. Walborn, Noel G. Harvey, Thomas A. Shepard, Richard M. Louth, D. A. Norman
Publikováno v:
Journal of Polymer Science Part B: Polymer Physics. 35:2617-2628
Recent studies have demonstrated that addition of a small quantity of dibenzylidene sorbitol (DBS) to a molten polymer may result in a physical gel if conditions permit the DBS molecules to self-organize into a three-dimensional network composed of h
Autor:
Noel G. Harvey, Yelena G. Tropsha
Publikováno v:
The Journal of Physical Chemistry B. 101:2259-2266
Poly(ethylene terephthalate) substrates were coated with thin films of silicon oxide deposited by magnetically enhanced chemical vapor deposition. The rates of oxygen and water vapor transport through the coated and uncoated film systems were obtaine
Autor:
Laurence J. Hirsch, Ronald J. Pettis, Elaine McVey, Barry H. Ginsberg, Diane E. Sutter, Lutz Heinemann, Leszek Nosek, Steven Keith, Noel G. Harvey, Marcus Hompesch, Christoph Kapitza
Publikováno v:
Diabetes technologytherapeutics. 13(4)
This study compared insulin lispro (IL) pharmacokinetics (PK) and pharmacodynamics (PD) delivered via microneedle intradermal (ID) injection with subcutaneous (SC) injection under euglycemic glucose clamp conditions.Ten healthy male volunteers were a
Publikováno v:
ChemInform. 22
Methods described previously for obtaining heterolysis (ΔH het ) and homolysis (ΔH homo ) enthalpies for bonds that can be cleaved to produce resonance-stabilized carbenium ions, anions, and radicals are extended to the study of carbon-oxygen bonds
Publikováno v:
ChemInform. 23