Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Noel G, McElvaney"'
Autor:
Brian J. Harvey, Noel G. McElvaney
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-30 (2024)
Abstract Biological sex differences exist for many airway diseases in which females have either worse or better health outcomes. Inflammatory airway diseases such as cystic fibrosis (CF) and asthma display a clear male advantage in post-puberty while
Externí odkaz:
https://doaj.org/article/863c57857957482596c0faa05c39f78a
Autor:
Ido Brami, Tsila Zuckerman, Ron Ram, Batia Avni, Galit Peretz, Daniel Ostrovsky, Yotam Lior, Caroline Faour, Oisin McElvaney, Noel G. McElvaney, Eli C. Lewis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 422 (2023)
α1-Antitrypsin (AAT), an acute-phase reactant not unsimilar to C-reactive protein (CRP), is a serine protease inhibitor that harbors tissue-protective and immunomodulatory attributes. Its concentrations appropriately increase during conditions of ex
Externí odkaz:
https://doaj.org/article/06a97daf5c92472e935ac2178e4a0801
Autor:
Alessandro N. Franciosi, April Tanzler, Jodi Goodwin, Pearce G. Wilcox, George M. Solomon, Albert Faro, Noel G. McElvaney, Damian G. Downey, Bradley S. Quon
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Background Increasing awareness of milder presentations of cystic fibrosis (CF) and greater interest in non-CF bronchiectasis are likely to lead to more CF screening by respiratory clinicians. As a result, adults who may not strictly fulfil CF diagno
Externí odkaz:
https://doaj.org/article/6f617089f9e54fb9bd7aabebc4efc679
Autor:
Jennifer Clarke, Pierce Geoghegan, Natalie McEvoy, Maria Boylan, Orna Ní Choileáin, Martin Mulligan, Grace Hogan, Aoife Keogh, Oliver J. McElvaney, Oisín F. McElvaney, John Bourke, Bairbre McNicholas, John G. Laffey, Noel G. McElvaney, Gerard F. Curley
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Objective We aimed to characterize the effects of prone positioning on respiratory mechanics and oxygenation in invasively ventilated patients with SARS-CoV-2 ARDS. Results This was a prospective cohort study in the Intensive Care Unit (ICU)
Externí odkaz:
https://doaj.org/article/94a79657b32f4c889115ec3f9fe0ca2d
Autor:
Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103894- (2022)
Summary: Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the protease-anti-protease balance in the circulation and
Externí odkaz:
https://doaj.org/article/8689f1b6c49645dc94c1c385411f7c38
Autor:
Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of
Externí odkaz:
https://doaj.org/article/af089efb2deb4f1abed964d43721db1d
Autor:
Paul J. McKiernan, Kevin P. Molloy, Arlene M. A. Glasgow, Noel G. McElvaney, Catherine M. Greene
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Altered microRNA expression patterns in bronchial brushings from people with versus without cystic fibrosis (CF) relate to functional changes and disease pathophysiology. The expression of microRNAs encoded on the X chromosome is also altered in peri
Externí odkaz:
https://doaj.org/article/68dd703e57e24bf2b32488e33cb71dc7
Autor:
Robin Caird, Michael Williamson, Azeez Yusuf, Debananda Gogoi, Michelle Casey, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6400 (2022)
In the lung, glycosaminoglycans (GAGs) are dispersed in the extracellular matrix (ECM) occupying the interstitial space between the capillary endothelium and the alveolar epithelium, in the sub-epithelial tissue and in airway secretions. In addition
Externí odkaz:
https://doaj.org/article/4924795d69214a859f5ae48ea939323e
Autor:
Oisín F. McElvaney, Daniel D. Fraughen, Oliver J. McElvaney, Tomás P. Carroll, Noel G. McElvaney
Publikováno v:
Expert Review of Respiratory Medicine. 17:191-202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5c31d0aa91579cf4328247c3daf9f0d
https://doi.org/10.1080/17476348.2023.2174973
https://doi.org/10.1080/17476348.2023.2174973
Autor:
Francesco Palmas, Jennifer Clarke, Romain A Colas, Esteban A Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J McElvaney, Oisin McElvaney, Razi Alalqam, Noel G McElvaney, Gerard F Curley, Jesmond Dalli
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256226 (2021)
Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths worldwide. A timely coordinated host-immune response represents the leading dr
Externí odkaz:
https://doaj.org/article/7f9563a15fbe4d7892bc459854e42685