Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Noel Francis"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Cytoprotection involving the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway is an important preventive strategy for normal cells against carcinogenesis. In our previous study, the chem
Externí odkaz:
https://doaj.org/article/3f3e31a039e649468752fb00e3253d42
Autor:
Janna Luessing, Maryam Sakhteh, Naoyuki Sarai, Louise Frizzell, Nikolay Tsanov, Kiefer Olaf Ramberg, Silvia Maretto, Peter Bernard Crowley, Noel Francis Lowndes
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109306- (2021)
Summary: 53BP1 is recruited to chromatin in the vicinity of DNA double-strand breaks (DSBs). We identify the nuclear kinesin, KIF18B, as a 53BP1-interacting protein and define its role in 53BP1-mediated DSB repair. KIF18B is a molecular motor protein
Externí odkaz:
https://doaj.org/article/4ff8cc20b6414bbf8d84ca540089cca2
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0223344 (2020)
Stilbenes are a group of chemicals characterized with the presence of 1,2-diphenylethylene. Previously, our group has demonstrated that synthesized (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) possesses potential chemoprevent
Externí odkaz:
https://doaj.org/article/ff74a31c3ce94a37a4e9eb05c44d9318
Autor:
John Kenneth Eykelenboom, Emma Christina Harte, Lynn Canavan, Ana Pastor-Peidro, Irene Calvo-Asensio, Marta Llorens-Agost, Noel Francis Lowndes
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 1095-1107 (2013)
Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent checkpoints regulate origin firin
Externí odkaz:
https://doaj.org/article/c24a8a79b3334c2188f6da805f084c88
Publikováno v:
Open Biology, Vol 6, Iss 9 (2016)
Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions. Here, we provide evidence supporting a novel role for p53 in the regu
Externí odkaz:
https://doaj.org/article/2d169f312e3f40ae8b317a9fdacf8fae
Autor:
Noel Francis Thomas, Chuan Gee Lim, Hiroshi Morita, Koichi Takeya, Khalijah Awang, Ibrahim Noorbatcha, Azhar Ariffin, Chin Hui Kee
Publikováno v:
Molecules, Vol 16, Iss 9, Pp 7267-7287 (2011)
The n-butyramido, isobutyramido, benzamido, and furancarboxamido functions profoundly modulate the electronics of the stilbene olefinic and NH groups and the corresponding radical cations in ways that influence the efficiency of the cyclization due p
Externí odkaz:
https://doaj.org/article/e3e884dd6e2e46aca0382b6ce020ffad
Publikováno v:
Molecules, Vol 16, Iss 2, Pp 1297-1309 (2011)
A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triaz
Externí odkaz:
https://doaj.org/article/196aa3ac69354ceb97db0871c7a43d93
Autor:
Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, Sri Nurestri Abd Malek
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer. The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of
Externí odkaz:
https://doaj.org/article/179423a031a146b0bd6ee0394bdeedcd
Autor:
Hexy, Mary, Jose, Subha Hency, Thomas, Abraham, Yedhukrishna, R., Varghese, Anvin Shaji, K.J., Noel Francis, Sheesh, Eby
Publikováno v:
In Biomedical Signal Processing and Control February 2025 100 Part A
Autor:
Carla Manuela Abreu, Ramesh Kumar, Danielle Hamilton, Andrew William Dawdy, Kevin Creavin, Sarah Eivers, Karen Finn, Jeremy Lynn Balsbaugh, Rosemary O'Connor, Patrick A Kiely, Jeffrey Shabanowitz, Donald F Hunt, Muriel Grenon, Noel Francis Lowndes
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003310 (2013)
The mediators of the DNA damage response (DDR) are highly phosphorylated by kinases that control cell proliferation, but little is known about the role of this regulation. Here we show that cell cycle phosphorylation of the prototypical DDR mediator
Externí odkaz:
https://doaj.org/article/33419ba8eac34a22b6783abd227ab08a