Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Noel Edwards"'
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1404 (2022)
SLC6A14 (ATB0,+) is unique among SLC proteins in its ability to transport 18 of the 20 proteinogenic (dipolar and cationic) amino acids and naturally occurring and synthetic analogues (including anti-viral prodrugs and nitric oxide synthase (NOS) inh
Externí odkaz:
https://doaj.org/article/e25bf220a65546b59212d9766070a338
Autor:
Mohamed H. Al-Hamed, John A. Sayer, Nada Alsahan, Noel Edwards, Wafaa Ali, Maha Tulbah, Faiqa Imtiaz
Publikováno v:
Genes, Vol 13, Iss 10, p 1687 (2022)
The use of next-generation sequencing (NGS) has helped in identifying many genes that cause congenital anomalies of the kidney and urinary tract (CAKUT). Bilateral renal agenesis (BRA) is the most severe presentation of CAKUT, and its association wit
Externí odkaz:
https://doaj.org/article/0c635cf83f7b4e99a7b85f839a91fd0a
Autor:
Jamie Willows, Maryam Al Badi, Chloe Richardson, Aisha Al Sinani, Noel Edwards, Sarah Rice, John A. Sayer
Publikováno v:
F1000Research, Vol 8 (2019)
Genetic mutations causing familial hypomagnesaemia syndromes are well-recognised. Affected patients can present with severe symptoms of hypomagnesaemia, such as seizures or cardiac arrhythmia. We report an affected child, from a consanguineous family
Externí odkaz:
https://doaj.org/article/46fce2fed8144670a8b9ebcc9b078149
Publikováno v:
F1000Research, Vol 8 (2019)
Genetic mutations causing familial hypomagnesaemia syndromes are well-recognised. Affected patients can present with severe symptoms of hypomagnesaemia, such as seizures or cardiac arrhythmia. We report an affected child, from a consanguineous family
Externí odkaz:
https://doaj.org/article/7bdc5824a0364e3f841f3d6a90418d5b
Autor:
Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 65:6513-6540
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approac
Autor:
Mohamed H. Al-Hamed, John A. Sayer, Nada Alsahan, Noel Edwards, Wafaa Ali, Maha Tulbah, Faiqa Imtiaz
Publikováno v:
Genes; Volume 13; Issue 10; Pages: 1687
The use of next-generation sequencing (NGS) has helped in identifying many genes that cause congenital anomalies of the kidney and urinary tract (CAKUT). Bilateral renal agenesis (BRA) is the most severe presentation of CAKUT, and its association wit
Autor:
Carsten A. Wagner, Mikael Heglind, John A. Sayer, Sumaya Alkanderi, William van’t Hoff, Stephen B. Walsh, Detlef Bockenhauer, Daniel Nilsson, Abdulrahim R.A. Bakhsh, Emma Ashton, Sven Enerbäck, Arezoo Daryadel, Feras E.B. Kokash, Noel Edwards, Robert Kleta, Felice D'Arco, Soline Bourgeois, Asma Deeb
Publikováno v:
Journal of the American Society of Nephrology. 29:1041-1048
Maintenance of the composition of inner ear fluid and regulation of electrolytes and acid-base homeostasis in the collecting duct system of the kidney require an overlapping set of membrane transport proteins regulated by the forkhead transcription f
Autor:
Andrew K Watson, Catriona M.H. Anderson, David T. Thwaites, Rebecca J. Hall, Nichola J. Conlon, T. Martin Embley, Timothy R. Cheek, Noel Edwards
Publikováno v:
Cellular and Molecular Life Sciences
Amino acid transporters are essential components of prokaryote and eukaryote cells, possess distinct physiological functions, and differ markedly in substrate specificity. Amino acid transporters can be both drug targets and drug transporters (bioava
Autor:
Simon J. Cook, Mathew P. Martin, Julie A. Tucker, Miller Duncan Charles, Timothy J. Blackburn, Stephanie M. Myers, Ai-Ching Wong, Nick C. Martin, Mercedes Arasta, Martin E.M. Noble, Huw D. Thomas, Ruth H. Bawn, Lan-Zhen Wang, Noel Edwards, Pamela A. Lochhead, Celine Cano, Suzannah J. Harnor, Tristan Reuillon, Laurent Rigoreau, Lauren Molyneux, Roger J. Griffin, David R. Newell, Bernard T. Golding, Tim Hammonds, Amy B. Heptinstall, P.J. Owen, Stephen R. Wedge, Ian R. Hardcastle, Leon Pang, Jane A. Endicott
Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellular phenotypes including endothelial cell angiogenesis and tumour cell motility. Novel ERK5 inhibitors were identified using high throughput screening,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b20469b74ddfa9b4388aacc50467a77
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docx
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docx
Autor:
Honglin, Feng, Noel, Edwards, Catriona M H, Anderson, Mike, Althaus, Rebecca P, Duncan, Yu-Ching, Hsu, Charles W, Luetje, Daniel R G, Price, Alex C C, Wilson, David T, Thwaites
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Plant sap-feeding insects thrive despite feeding exclusively on a diet lacking in essential amino acids. This nutritional deficit is countered through endosymbiotic relationships with microbial symbionts. Nonessential amino acids, vital