Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Noel A. Powell"'
Autor:
Surabhi Nair, Mohammed Q. Qutaish, Noel Aaron Powell, Dima Chaar, Ali Ghayoor, Jack Heimann, Jesse J. Winters, Jenna M. Sullivan, Larry W. Hardy, Jon Oscherwitz, Israel Liberzon, Lauren E. Chaby, Ildiko Polyak, Elizabeth Rodriguez
Publikováno v:
Behavioural Brain Research. 396:112902
To interrogate whether altered function of the hippocampal-mPFC circuit underlies the deficit in fear extinction recall in rats subjected to single-prolonged stress (SPS), changes in brain region-specific metabolic rate were measured in male rats (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b3db76315ba0485690508e9a6816e3
https://doi.org/10.1016/j.bbr.2020.112902
https://doi.org/10.1016/j.bbr.2020.112902
Autor:
Justin A. Caravella, Daliya Banerjee, Noel A. Powell, Jason D. Fontenot, Andres McKenzie, Istvan J. Enyedy, Victor Sukbong Hong, Douglas Marcotte, Laura Silvian, Jianhua Chao, Kurt Van Vloten
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2459-2463
RORγ plays a critical role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including T cells, γδ T cells, and innate lymphoid cells. RORγ-mediated inflammation has been linked to susceptibility to Crohn's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136b750dc7319912bb39e7e65933a62
https://doi.org/10.1016/j.bmcl.2016.03.109
https://doi.org/10.1016/j.bmcl.2016.03.109
Autor:
Q. Kevin Fang, John Emmerson Campbell, Una Campbell, Philip Jones, Noel Aaron Powell, Vadim Alexandrov, Emily Sabath, Liming Shao, Kerry L. Spear, Irene Morganstern, Thomas H. Large, Taleen Hanania, Hua M. Zhong
Publikováno v:
MedChemComm. 7:1093-1101
Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe09535f97f43c9fa55f35e30eca47e3
https://doi.org/10.1039/c6md00128a
https://doi.org/10.1039/c6md00128a
Autor:
Cornel Catana, Lisa A. Perrin, Jeff Ohren, Jeremy J. Edmunds, John Quin, Derek James Sheehan, Sangita M. Baxi, Jennifer K. Hoffman, Jeffrey T. Kohrt, Amy M. Delaney, Fred L. Ciske, Michael Kaufman, Noel A. Powell, Patrick I. McConnell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1046-1050
We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e92f1efe3db497d0cd75fdd02d80d7f
https://doi.org/10.1016/j.bmcl.2012.12.013
https://doi.org/10.1016/j.bmcl.2012.12.013
Autor:
Jo Ann Davis, Christopher F. Bigge, Mehran Jalaie, Seungil Han, Jeffrey F. Ohren, Jing Chen, Noel A. Powell, Fred A. Ciske, Agustin Casimiro-Garcia, Teresa Ellis, Ronald J. Heemstra, Declan Flynn, Nadia Esmaeil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:767-772
Identification of a series of imidazo[4,5-c]pyridin-4-one derivatives that act as dual angiotensin II type 1 (AT1) receptor antagonists and peroxisome proliferator-activated receptor-γ (PPARγ) partial agonists is described. Starting from a known AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d7100e721853331ca8766501b9c589
https://doi.org/10.1016/j.bmcl.2012.11.088
https://doi.org/10.1016/j.bmcl.2012.11.088
Autor:
Yuli Wang, Derek James Sheehan, Cornel Catana, Doh-Yeel Lee, Amy M. Delaney, Lisa A. Perrin, Fang Sun, Jeff Ohren, Frank Schwende, Kevin J. Filipski, Patrick I. McConnell, Jeffrey T. Kohrt, Noel A. Powell, Michael Kaufman, Francis Bourbonais, Huifen Chen, Jeremy E. Edmunds
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:190-193
We report the discovery of a novel series of spiroindoline-based inhibitors of Sky kinase that bind in the ATP-binding site and exhibit high levels of kinome selectivity through filling the Ala571-subpocket. These inhibitors exhibit moderate oral bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0525eacb86f519d2a615c9d6eaf5f300
https://doi.org/10.1016/j.bmcl.2011.11.036
https://doi.org/10.1016/j.bmcl.2011.11.036
Autor:
Noel A. Powell, Joseph E. Duran, Timothy J. Hagen, Robert M. Kennedy, Fred L. Ciske, Daniel D. Holsworth, Cuiman Cai, Jeremy J. Edmunds, Daniele M. Leonard
Publikováno v:
Tetrahedron Letters. 51:4441-4444
We have optimized the Pd-catalyzed intramolecular α-arylation of 2-(2-halo-benzyl)-cyclohexanones and found that the use of 2-(dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl (X-Phos) as an added ligand led to a reproducible, effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9638ff892a3e7619ecfabc921fb66316
https://doi.org/10.1016/j.tetlet.2010.06.085
https://doi.org/10.1016/j.tetlet.2010.06.085
Publikováno v:
International Journal of Peptide and Protein Research. 44:427-434
RGD peptides are known as important ligands for integrin receptors in the cell adhesion process. The selectivity of RGD peptides for a certain integrin receptor is partly dependent on the RGD conformation and the residues surrounding the RGD sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d812abd4fbd532bdbff7c876602eca
https://doi.org/10.1111/j.1399-3011.1994.tb00178.x
https://doi.org/10.1111/j.1399-3011.1994.tb00178.x
Autor:
Chad A. Van Huis, Wendy Collard, Cuiman Cai, Michelle Mastronardi, Roxane Collins, Michael J. Ryan, Jeremy J. Edmunds, Erli Zhang, Mehran Jalaie, Chungang Gu, Ken Mennen, John W. Bryant, Patrick I. McConnell, Fred L. Ciske, Suzie Ferreira, Jacqueline E. Day, Daniel D. Holsworth, Noel A. Powell, Igor Mochalkin
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5912-5949
We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitution pattern exhibit potent renin inhibition and go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5134728dfb02df8a38ff3f31d48c05e
https://doi.org/10.1016/j.bmc.2007.05.069
https://doi.org/10.1016/j.bmc.2007.05.069
Autor:
Joanne L. Viney, Victor Hong, Arthur G. Taveras, Chi-Chi Peng, Daliya Banerjee, Kevin Guertin, Laura Silvian, Richard H. Hutchings, Howard Jones, Douglas Marcotte, Liaomin Peng, Noel A. Powell, Kevin Little, Jianhua Chao, Tonika Bohnert, Kurt Van Vloten, Istvan J. Enyedy, Jason D. Fontenot
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(15)
RORγt is a pivotal regulator of a pro-inflammatory gene expression program implicated in the pathology of several major human immune-mediated diseases. Evidence from mouse models demonstrates that genetic or pharmacological inhibition of RORγ activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12513df04b12ba87745ee6c80e88a93
https://pubmed.ncbi.nlm.nih.gov/26048806
https://pubmed.ncbi.nlm.nih.gov/26048806