Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release.

Autor: Zhou X; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH Zürich, Zürich, Switzerland., Stine C; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA.; Molecular and Cellular Biology, University of Washington School of Medicine, Seattle, WA, USA., Prada PO; Max Planck Institute for Metabolism Research, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; School of Applied Sciences, State University of Campinas (UNICAMP), Limeira, Sao Paulo, Brazil., Fusca D; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Institute of Zoology, Department of Biology, University of Cologne, Cologne, Germany., Assoumou K; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland., Dernic J; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland., Bhat MA; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland., Achanta AS; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA., Johnson JC; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA., Pasqualini AL; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA., Jadhav S; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA., Bauder CA; Max Planck Institute for Metabolism Research, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Steuernagel L; Max Planck Institute for Metabolism Research, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Ravotto L; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland., Benke D; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH Zürich, Zürich, Switzerland., Weber B; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH Zürich, Zürich, Switzerland., Suko A; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA., Palmiter RD; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute and Departments of Biochemistry and Genome Sciences, University of Washington, Seattle, WA, 98195, USA., Stoeber M; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland., Kloppenburg P; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Institute of Zoology, Department of Biology, University of Cologne, Cologne, Germany., Brüning JC; Max Planck Institute for Metabolism Research, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Cologne, Germany., Bruchas MR; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA. mbruchas@uw.edu.; Departments of Anesthesiology and Pharmacology and Bioengineering, University of Washington, Seattle, WA, USA. mbruchas@uw.edu.; Molecular and Cellular Biology, University of Washington School of Medicine, Seattle, WA, USA. mbruchas@uw.edu., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland. patriarchi@pharma.uzh.ch.; Neuroscience Center Zurich, University and ETH Zürich, Zürich, Switzerland. patriarchi@pharma.uzh.ch.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 25; Vol. 15 (1), pp. 5353. Date of Electronic Publication: 2024 Jun 25.

An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food.

Autor: Wilson L; Department of Psychology, Wake Forest University, Winston-Salem, NC, USA. Electronic address: lindsey.wilson@duke.edu., Klausner M; Department of Psychology, Wake Forest University, Winston-Salem, NC, USA., Chuang S; Department of Psychology, Wake Forest University, Winston-Salem, NC, USA., Patel S; Department of Psychology, Wake Forest University, Winston-Salem, NC, USA. Electronic address: patesh20@wfu.edu., Pratt WE; Department of Psychology, Wake Forest University, Winston-Salem, NC, USA. Electronic address: prattwe@wfu.edu.

Publikováno v: Behavioural brain research [Behav Brain Res] 2024 Mar 28; Vol. 462, pp. 114895. Date of Electronic Publication: 2024 Feb 03.

Induction of orofacial pain potentiates fibromyalgia symptoms in mice: Relevance of nociceptin system.

Autor: Volkweis MCC; PUCRS, Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil., Tomasi LA; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Curso de Graduação em Farmácia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil., Santos GC; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Curso de Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil., Dagnino APA; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Porto Alegre, RS, Brazil., Estrázulas M; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Porto Alegre, RS, Brazil., Campos MM; PUCRS, Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Curso de Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Porto Alegre, RS, Brazil. Electronic address: maria.campos@pucrs.br.

Publikováno v: Life sciences [Life Sci] 2024 Dec 01; Vol. 358, pp. 123183. Date of Electronic Publication: 2024 Oct 28.

Effect of chronic delivery of the NOP/MOR partial agonist AT-201 and NOP antagonist J-113397 on heroin relapse in a rat model of opioid maintenance.

Autor: Bossert JM; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A.. jennifer.bossert@nih.gov., Caldwell KE; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A., Korah H; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A., Batista A; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A., Bonbrest H; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A., Fredriksson I; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A., Jackson SN; Translational Analytical Core, IRP/NIDA/NIH, Baltimore, MD, U.S.A., Sulima A; Molecular Targets and Medications Discovery Branch, IRP/NIDA, NIAAA/NIH, Baltimore, MD, U.S.A., Rice KC; Molecular Targets and Medications Discovery Branch, IRP/NIDA, NIAAA/NIH, Baltimore, MD, U.S.A., Zaveri NT; Astraea Therapeutics, 320 Logue Avenue, Mountain View, CA, USA., Shaham Y; Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, U.S.A.

Publikováno v: Psychopharmacology [Psychopharmacology (Berl)] 2024 Dec; Vol. 241 (12), pp. 2497-2511. Date of Electronic Publication: 2024 Sep 13.

LY2940094, an NOPR antagonist, promotes oligodendrocyte generation and myelin recovery in an NOPR independent manner.

Autor: Duan Y; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China., Ye C; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Liao J; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Xie X; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China. Electronic address: xxie@simm.ac.cn.

Publikováno v: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2024 Sep; Vol. 21 (5), pp. e00424.