Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Nobuyuki Yanagihara"'
Autor:
Kaori Kato, Masato Tsutsui, Shingo Noguchi, Yukitoshi Iha, Keisuke Naito, Takaaki Ogoshi, Chinatsu Nishida, Masahiro Tahara, Hirotaka Yamashita, Ke-Yong Wang, Yumiko Toyohira, Nobuyuki Yanagihara, Hiroaki Masuzaki, Hiroaki Shimokawa, Akihide Tanimoto, Kazuhiro Yatera
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice in which all three NOS isoforms were deleted. Under basal conditions, the triple n/
Externí odkaz:
https://doaj.org/article/7fac18b209204ef195b39fc6a91f7652
Autor:
Takafumi Horishita, Yuichi Ogata, Reiko Horishita, Ryo Fukui, Kuniaki Moriwaki, Susumu Ueno, Nobuyuki Yanagihara, Yasuhito Uezono, Yuka Sudo, Kouichiro Minami
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 4, Pp 140-147 (2020)
Carvacrol is the predominant monoterpene in essential oils from many aromatic plants. Several animal studies showing analgesic effects of carvacrol indicate potential of carvacrol as a new medication for patients with refractory pain. Voltage-gated s
Externí odkaz:
https://doaj.org/article/490bd51b04164ad497dfc78207fd2865
Autor:
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takashi Kawasaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 93-97 (2018)
The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure. The voltage-gated sodium channels (Nav) α subunit Nav1.3 is tho
Externí odkaz:
https://doaj.org/article/10d466bced6e43b88f420d6a937a3725
Autor:
Xiaojia Li, Takafumi Horishita, Yumiko Toyohira, Hui Shao, Jie Bai, Haixia Bo, Xinbo Song, Shin Ishikane, Yukari Yoshinaga, Noriaki Satoh, Masato Tsutsui, Nobuyuki Yanagihara
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 4, Pp 268-275 (2017)
Extract of pine nodules (matsufushi) formed by bark proliferation on the surface of trees of Pinus tabulaeformis or Pinus massoniana has been used as an analgesic for joint pain, rheumatism, neuralgia, dysmenorrhea and other complaints in Chinese tra
Externí odkaz:
https://doaj.org/article/fb1e89c5ffaa42ba89f934c09dc81430
Autor:
Masato Tsutsui, Akihide Tanimoto, Masahito Tamura, Hiroshi Mukae, Nobuyuki Yanagihara, Hiroaki Shimokawa, Yutaka Otsuji
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 1, Pp 42-52 (2015)
Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and endothelial NOSs), all of which are expressed in almost all tissues and organs in humans. The regulatory roles of NOSs in vivo have been investigated in pharmac
Externí odkaz:
https://doaj.org/article/a74e3ee762f64f6b839528794a32d12f
Autor:
Nobuyuki Yanagihara, Han Zhang, Yumiko Toyohira, Keita Takahashi, Susumu Ueno, Masato Tsutsui, Kojiro Takahashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 2, Pp 123-128 (2014)
Flavonoids are biologically active polyphenolic compounds widely distributed in plants. Recent research has focused on high dietary intake of flavonoids because of their potential to reduce the risks of diseases such as cardiovascular diseases, diabe
Externí odkaz:
https://doaj.org/article/13429865ba4348648ce2405a0ea0b6e9
Autor:
Hirohide Inagaki, Yumiko Toyohira, Keita Takahashi, Susumu Ueno, Go Obara, Toshinori Kawagoe, Masato Tsutsui, Toru Hachisuga, Nobuyuki Yanagihara
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 1, Pp 66-75 (2014)
Abstract.: We previously reported the occurrence and function of plasma membrane estrogen receptors in cultured bovine adrenal medullary cells. Here we report the effects of raloxifene and tamoxifen, selective estrogen receptor modulators, on plasma
Externí odkaz:
https://doaj.org/article/b603c4c15a304a1983129250dd2ef659
Autor:
Go Obara, Yumiko Toyohira, Hirohide Inagaki, Keita Takahashi, Takafumi Horishita, Takashi Kawasaki, Susumu Ueno, Masato Tsutsui, Takeyoshi Sata, Nobuyuki Yanagihara
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 2, Pp 138-147 (2013)
(±)-Pentazocine (PTZ), a non-narcotic analgesic, is used for the clinical management of moderate to severe pain. To study the effect of PTZ on the descending noradrenergic inhibitory system, in the present study we examined the effect of [3H]norepin
Externí odkaz:
https://doaj.org/article/de4da72bef9b4deeb0c4e7a436537c4e
Autor:
Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 1, Pp 54-58 (2012)
Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of
Externí odkaz:
https://doaj.org/article/dd256dd4d40f4de9bf27cc1b7230afde
Autor:
Naoya Morisada, Masayoshi Nomura, Hisae Nishii, Yumi Furuno, Mayuko Sakanashi, Ken Sabanai, Yumiko Toyohira, Susumu Ueno, Seiji Watanabe, Masahito Tamura, Tetsuro Matsumoto, Akihide Tanimoto, Yasuyuki Sasaguri, Hiroaki Shimokawa, Koichi Kusuhara, Nobuyuki Yanagihara, Akira Shirahata, Masato Tsutsui
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 4, Pp 379-389 (2010)
Abstract.: The role of nitric oxide (NO) derived from all three NO synthases (NOSs) in renal lesion formation remains to be fully elucidated. We addressed this point in mice lacking all NOSs. Renal injury was induced by unilateral ureteral obstructio
Externí odkaz:
https://doaj.org/article/ce00b35f732f45f1b7369366aef7d29a