Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Nobuyuki Udagawa"'
Autor:
Katsuhiko Takahashi, Hitoshi Amano, Tomohiko Urano, Minqi Li, Meiko Oki, Kazuhiro Aoki, Norio Amizuka, Keiichi I. Nakayama, Keiko Nakayama, Nobuyuki Udagawa, Nobuaki Higashi
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
A cyclin-dependent kinase (CDK) inhibitor, p57Kip2, is an important molecule involved in bone development; p57Kip2-deficient (p57-/-) mice display neonatal lethality resulting from abnormal bone formation and cleft palate. The modulator 1α,25-dihydr
Externí odkaz:
https://doaj.org/article/a71aa69fb2fa462f83fc66e330f4eba1
Autor:
Daisuke Nishida, Atsushi Arai, Lijuan Zhao, Mengyu Yang, Yuko Nakamichi, Kanji Horibe, Akihiro Hosoya, Yasuhiro Kobayashi, Nobuyuki Udagawa, Toshihide Mizoguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Bone-resorbing osteoclasts are regulated by the relative ratio of the differentiation factor, receptor activator NF-kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG). Dental tissue-localized-resorbing cells called odontocl
Externí odkaz:
https://doaj.org/article/0bc798aa5f944ff192e4fdd53c5c0b34
Autor:
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita‐Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, Nobuyuki Udagawa, Johji Kato, Kazuo Kitamura
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 8 (2022)
Background The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor‐kappa B ligand in the vascular structure, has not been elucidated. The study aim was to determine if osteoprote
Externí odkaz:
https://doaj.org/article/225fb59da20e4b74987309e83af4e1a3
Autor:
Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, Nobuyuki Udagawa, Shintaro Sato, Tsuneyasu Kaisho, Toshihiko Iwanaga, Koji Hase
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cel
Externí odkaz:
https://doaj.org/article/99645e0b7f85428f9c603bf38fe18aa1
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4895 (2022)
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the pr
Externí odkaz:
https://doaj.org/article/1918465f3c9d4414b4ecfcc2b57824d3
Autor:
Mengyu Yang, Atsushi Arai, Nobuyuki Udagawa, Toru Hiraga, Zhao Lijuan, Susumu Ito, Toshihisa Komori, Takeshi Moriishi, Koichi Matsuo, Kouji Shimoda, Ali H. Zahalka, Yasuhiro Kobayashi, Naoyuki Takahashi, Toshihide Mizoguchi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Bone marrow mesenchymal stem and progenitor cells (BM-MSPCs) maintain homeostasis of bone tissue by providing osteoblasts. Although several markers have been identified for labeling of MSPCs, these labeled cells still contain non-BM-MSPC pop
Externí odkaz:
https://doaj.org/article/cadaaf04dcdd4fafb0cada7bb88b1263
Autor:
Yuki Ozaki, Masanori Koide, Yuriko Furuya, Tadashi Ninomiya, Hisataka Yasuda, Midori Nakamura, Yasuhiro Kobayashi, Naoyuki Takahashi, Nobuo Yoshinari, Nobuyuki Udagawa
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184904 (2017)
Osteoblasts express two key molecules for osteoclast differentiation, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG), a soluble decoy receptor for RANKL. RANKL induces osteoclastogenesis, while OPG inhibits it by blocking the b
Externí odkaz:
https://doaj.org/article/2487bcb9da944fa09fe246d8594a0abf
Autor:
Kohei Murakami, Yasuhiro Kobayashi, Shunsuke Uehara, Takako Suzuki, Masanori Koide, Teruhito Yamashita, Midori Nakamura, Naoyuki Takahashi, Hiroyuki Kato, Nobuyuki Udagawa, Yukio Nakamura
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181126 (2017)
The Janus kinases (Jaks) are hubs in the signaling process of more than 50 cytokine or hormone receptors. However, the function of Jak in bone metabolism remains to be elucidated. Here, we showed that the inhibition of Jak1 and/or Jak2 in osteoblast-
Externí odkaz:
https://doaj.org/article/ae3fb9ed16314cea8aa3e2c0e0e8c621
Autor:
Teruhito Yamashita, Shunsuke Uehara, Nobuyuki Udagawa, Feng Li, Shigetoshi Kadota, Hiroyasu Esumi, Yasuhiro Kobayashi, Naoyuki Takahashi
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85878 (2014)
Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. Here, we showed that arctigenin inhibit
Externí odkaz:
https://doaj.org/article/ee6323f7d958456e910e8521ad946a62
Autor:
Yukina Miyamoto, Tomoka Hasegawa, Hiromi Hongo, Tomomaya Yamamoto, Mai Haraguchi-Kitakamae, Miki Abe, Haruhi Maruoka, Hotaka Ishizu, Tomohiro Shimizu, Yasuyuki Sasano, Nobuyuki Udagawa, Minqi Li, Norio Amizuka
Publikováno v:
Journal of Oral Biosciences. 65:175-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b845a9caacaaddc9c9dead4925ea00
https://doi.org/10.1016/j.job.2023.04.003
https://doi.org/10.1016/j.job.2023.04.003