Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Nobuyuki Takakura"'
Autor:
Yuichi Matsui, Fumitaka Muramatsu, Hajime Nakamura, Yoshimi Noda, Kinnosuke Matsumoto, Haruhiko Kishima, Nobuyuki Takakura
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunctio
Externí odkaz:
https://doaj.org/article/41143db9623d4f73b40ca650899d8733
Autor:
Zeynep Bal, Nobuyuki Takakura
Publikováno v:
Gels, Vol 10, Iss 8, p 544 (2024)
Osteonecrosis of the femoral head (ONFH) is a vascular disease of unknown etiology and can be categorized mainly into two types: non-traumatic and traumatic ONFH. Thus, understanding osteogenic–angiogenic coupling is of prime importance in finding
Externí odkaz:
https://doaj.org/article/30ee9e90c1e5474e9a74869e59213f09
Autor:
Fitriana N. Rahmawati, Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Hirotaka Konishi, Weizhen Jia, Nobuyuki Takakura
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been characterized, nor has
Externí odkaz:
https://doaj.org/article/8a70438de9cb43258fd801f999c3a70e
Autor:
Koichi Inukai, Kazuyoshi Kise, Yumiko Hayashi, Weizhen Jia, Fumitaka Muramatsu, Naoki Okamoto, Hirotaka Konishi, Keigo Akuta, Hiroyasu Kidoya, Nobuyuki Takakura
Publikováno v:
Pathology and Oncology Research, Vol 29 (2023)
Several reports indicate that apelin is often over-expressed in tumors, and therefore it has been suggested that the apelin–apelin receptor (APJ) system may induce tumor progression. In contrast, our previous research revealed high expression of th
Externí odkaz:
https://doaj.org/article/6ae248833a1b4a64bf63218aed2a6e66
Autor:
Sachio Shibata, Satoshi Sogabe, Masanori Miwa, Takuya Fujimoto, Nobuyuki Takakura, Akihiko Naotsuka, Shuji Kitamura, Tomohiro Kawamoto, Tomoyoshi Soga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell pr
Externí odkaz:
https://doaj.org/article/f9c30a90aae44dd1abe0ffa04ef29aac
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth b
Externí odkaz:
https://doaj.org/article/4e8ea4612f98423499fc875b5a604869
Autor:
Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary an
Externí odkaz:
https://doaj.org/article/2d73afe6425b4fe38178265b2b6f30da
Autor:
Yohei Tsukada, Fumitaka Muramatsu, Yumiko Hayashi, Chiaki Inagaki, Hang Su, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditi
Externí odkaz:
https://doaj.org/article/3dc28d15ce0443be96af6006545bcfeb
Autor:
Kentaro Tsukamoto, Naoaki Shinzawa, Akito Kawai, Masahiro Suzuki, Hiroyasu Kidoya, Nobuyuki Takakura, Hisateru Yamaguchi, Toshiki Kameyama, Hidehito Inagaki, Hiroki Kurahashi, Yasuhiko Horiguchi, Yohei Doi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. Here, Tsukamoto et al. show that this effect is caused by a secreted protein that induces cell proliferation and angiogenesis by acting as an analog of
Externí odkaz:
https://doaj.org/article/7c6bada9dc8c434fa191c36a4398ea29
Autor:
Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi, Nobuyuki Takakura
Publikováno v:
Inflammation and Regeneration, Vol 39, Iss 1, Pp 1-8 (2019)
Abstract Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell properties because o
Externí odkaz:
https://doaj.org/article/f2c038482d5945bab51c15e4ea9b213b