Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nobuyuki Murayama"'
Autor:
Nobuyuki Murayama, Takashi Izumi, Shin-ichi Inoue, Takuo Washio, Makiko Yamada, Hideo Takakusa, Eiko Suzuki, Masakatsu Kotsuma, Makoto Takei
Publikováno v:
Xenobiotica. 47:1090-1103
1. Esaxerenone (CS-3150) is a novel non-steroidal mineralocorticoid receptor antagonist. The pharmacokinetics, tissue distribution, excretion, and metabolism of esaxerenone were evaluated in rats and monkeys. 2. Following intravenous dosing of esaxer
Autor:
Yuri Tsuruya, Noriko Okudaira, Hiroyuki Kusuhara, Yuji Kumagai, Dominik Heer, Atsushi Kurihara, Nobuyuki Murayama, Yuichiro Imamura, Kazuya Maeda, Katja Damme, Yuichi Sugiyama, Takashi Izumi
Publikováno v:
Drug Metabolism and Disposition. 42:685-694
6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells. This study aimed to examine the contribution of OAT3
Publikováno v:
Drug Metabolism and Disposition. 41:1888-1895
Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor blocker (ARB). We recently identified carboxymethylenebutenolidase homolog (CMBL) as the responsible enzyme for OM bioactivation in humans. In the present study, we compared t
Autor:
Takashi Izumi, Noriko Okudaira, Yoshiyuki Yabe, Takanori Aoki, Nobuyuki Murayama, Atsushi Kurihara, Noriko Masubuchi, Masataka Oitate, Tsuyoshi Karibe, Takashi Ito
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:423-430
Interspecies allometric scaling is a useful tool for calculating human pharmacokinetic (PK) parameters from data in animals. In this study, in order to determine the scaling exponent in a simple allometric equation that can predict human clearance (C
Autor:
Takashi Izumi, Nobuyuki Murayama, Katsuhisa Inoue, Yuichiro Imamura, Hiroyuki Kusuhara, Yuichi Sugiyama, Hiroaki Yuasa, Atsushi Kurihara, Noriko Okudaira, Osamu Okazaki
Publikováno v:
Clinical Pharmacology & Therapeutics. 89:81-88
The aim of this study was to examine the mechanism underlying the elevation in serum creatinine levels caused by a novel des-fluoro(6)-quinolone antibacterial agent, DX-619, in healthy subjects. hOCT2 showed a prominent uptake of creatinine (K(m) = 5
Publikováno v:
Journal of Pharmaceutical Sciences. 95:1763-1770
This study evaluates the distribution profile in tissues and concentrative uptake mechanism for a cationic compound of DX-9065a in rats. After a single intravenous dosing of [ 14 C]-DX-9065a to male rats, higher levels of radioactivity were observed
Autor:
Masami Fujita, Hirohisa Yamada, Takashi Inoue, Yasuko Terada, Satoshi Kunitada, Nobuyuki Murayama, Makoto Tanaka, Yasuo Ikeda
Publikováno v:
Clinical Pharmacology & Therapeutics. 66:258-264
Objective The aim of this study was to assess the tolerability, pharmacokinetic and pharmacodynamic properties of DX-9065a, a novel low-molecule specific factor Xa inhibitor in healthy male volunteers. Methods DX-9065a was intravenously administered
Autor:
Kenichi Sudo, Nobuyuki Murayama
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 692:389-396
A simple HPLC method for determination of DX-9065a in human urine and feces was developed. The drug was extracted by Bond Elut CBA, a cation-exchange solid-phase extraction cartridge. The extracted drug was analyzed by HPLC with UV detection at 242 n
Publikováno v:
BUNSEKI KAGAKU. 44:839-843
シクロヘキサン環を有する抗アレルギー用薬をヒトに投与後得られた尿試料から,代謝物M-6を新たに単離同定した.M-6はシクロヘキサン環3位のエクアトリアル位に水酸化を受けた結果不斉
Autor:
Atsushi Kurihara, Noriko Okudaira, Katsuhisa Inoue, Yuichiro Imamura, Takashi Izumi, Hiroaki Yuasa, Nobuyuki Murayama, Hiroyuki Kusuhara, Yuichi Sugiyama
Publikováno v:
Pharmaceutical research. 30(2)
To examine the effect of the fluoroquinolone DX-619 on CYP3A4 and urinary excretion of 6β-hydroxycortisol, an endogenous probe of hepatic CYP3A4 activity, in healthy subjects.The effect of DX-619 on CYP3A4 was examined in human liver microsomes. The