Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nobuyuki Kasai"'
Publikováno v:
IEEJ Transactions on Electronics, Information and Systems. 128:723-726
Monolithic dual-wavelength high-power laser diode is strongly required by DVD-R/CD-R dual optical disc drives for the purpose of not only cost reduction but also drive size minimization. In this paper, we will report on a newly developed monolithic d
Autor:
Kengo Sakaguchi, Fumio Sugawara, Hiromi Yoshida, Nobuyuki Kasai, Hiroshi Iijima, Yoshiyuki Mizushina
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 5:613-625
It was found that a class of sulfolipids known as sulfo-quinovosyl-acyl-glycerols (SQAGs) from ferns and algae are potent inhibitors of eukaryotic DNA polymerase alpha and beta and effective anti-neoplastic agents. In developing a procedure for the c
Autor:
Masahiko Oshige, Hiroyuki Chiku, Siroh Ibe, Fumio Sugawara, Kengo Sakaguchi, Osamu Koiwai, Yukinobu Uchiyama, Nobuyuki Kasai, Shinji Kamisuki, Junko Tagami
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1725:298-304
Studies of mammalian terminal deoxyribonucleotidyltransferase (TdT) are facilitated by use of inhibitors that selectively knock down the activity of the enzyme. We have screened for selective inhibitors of TdT and identified a natural compound with t
Autor:
Takayuki Yamazaki, Yoshiyuki Mizushina, Kengo Sakaguchi, Tadayasu Ohkubo, Hiroshi Murata, Fumio Sugawara, Nobuyuki Kasai
Publikováno v:
FEBS Journal. 272:4349-4361
We have previously reported that sulfoquinovosylmonoacylglycerol (SQMG) is a potent inhibitor of mammalian DNA polymerases. DNA polymerase beta (pol beta) is one of the most important enzymes protecting the cell against DNA damage by base excision re
Autor:
Taichi Yamamoto, Norihiro Sakaguchi, Kengo Sakaguchi, Nobuyuki Kasai, Yukinobu Uchiyama, Hiroyuki Chiku, Yoko Mori, Toyotaka Ishibashi, Seisuke Kimura, Ai Saotome
Publikováno v:
Biochemical and Biophysical Research Communications. 334:43-50
Previously, we described a novel DNA polymerase, designated as OsPolI-like, from rice. The OsPolI-like showed a high degree of sequence homology with the DNA polymerase I of cyanobacteria and was localized in the plastid. Here, we describe two PolI-l
Publikováno v:
Journal of Biomolecular NMR. 32:83-88
Publikováno v:
Current Computer Aided-Drug Design. 1:79-91
We found that nervonic acid (NA, 15cis-tetracosenoic acid) which is a cis-configurated unsaturated long-chain fatty acid and lithocholic acid (LCA, hydroxy-5β-cholan-24-oic acid) which is a bile acid are selective inhibitors of mammalian DNA polymer
Autor:
Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi, Masaharu Takemura, Shinya Hanashima, Yoshiyuki Mizushina, Katsumi Miura, Nobuyuki Kasai
Publikováno v:
Biochemistry. 43:10669-10677
We reported previously that lithocholic acid (LCA, 3-alpha-hydroxy-5-beta-cholan-24-oic acid), one of the major compounds in the secondary bile acids, selectively inhibited the activity of mammalian DNA polymerase beta (pol beta) [Mizushina, Y., Ohku
Autor:
Chikako Murakami, Kenji Mori, Masahiko Oshige, Osamu Koiwai, Toyofumi Yamaguchi, Mineo Saneyoshi, Noriko Shimazaki, Hiromi Yoshida, Yoshiyuki Mizushina, Kengo Sakaguchi, Nobuyuki Kasai, Hirosato Takikawa, Fumio Sugawara, Xianai Xu
Publikováno v:
Journal of Biochemistry. 133:541-552
Hippospongic acid A (HA-A) is a novel natural triterpene metabolite that exhibits inhibitory activity against the gastrulation of starfish embryos isolated from a marine sponge, Hippospongia sp. We succeeded in chemically synthesizing the natural ena
Autor:
Hitomi Asahara, Atsushi Kato, Hiromi Yoshida, Yoshiyuki Mizushina, Kengo Sakaguchi, Xianai Xu, Fumio Sugawara, Nobuyuki Kasai, Masaharu Takemura, Naoki Asano, Stuart Linn
Publikováno v:
Biochemical and Biophysical Research Communications. 304:78-85
The pyrrolidine alkaloids mimicking the structures of pentose with nitrogen in the ring are known to be inhibitors of glycosidases. We report here that a compound belonging to this category is an inhibitor of eukaryotic DNA polymerases. Among the eig