Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Nobuyuki, Kato"'
Autor:
Fumiyasu Nakamura, Haruhiko Takeda, Yoshihide Ueda, Atsushi Takai, Ken Takahashi, Yuji Eso, Soichi Arasawa, Eriko Iguchi, Takahiro Shimizu, Masako Mishima, Ken Kumagai, Taiki Yamashita, Shinji Uemoto, Nobuyuki Kato, Hiroyuki Marusawa, Akihiro Sekine, Hiroshi Seno
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The emergence of hepatitis C virus (HCV) with resistance-associated substitution (RAS), produced by mutations in the HCV genome, is a major problem in direct acting antivirals (DAA) treatment. This study aimed to clarify the mutational spect
Externí odkaz:
https://doaj.org/article/526c65e7dd094316aad06e4b64ba4aa5
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 356-373 (2021)
Abstract We previously found that N‐89 and its derivative, N‐251, which are being developed as antimalarial compounds, showed multiple antiviral activities including hepatitis C virus (HCV). In this study, we focused on the most characterized ant
Externí odkaz:
https://doaj.org/article/fc814201086c4834a23695951c5967a9
Autor:
Youki Ueda, Weilin Gu, Hiromichi Dansako, Hye-Sook Kim, Sayaka Yoshizaki, Nobuaki Okumura, Tomohiro Ishikawa, Hironori Nishitsuji, Fumihiro Kato, Takayuki Hishiki, Shinya Satoh, Koji Ishii, Michiaki Masuda, Kunitada Shimotohno, Masanori Ikeda, Nobuyuki Kato
Publikováno v:
Biochemistry and Biophysics Reports, Vol 15, Iss , Pp 1-6 (2018)
The chemically synthesized endoperoxide compound N-89 and its derivative N-251 were shown to have potent antimalarial activity. We previously demonstrated that N-89 and N-251 potently inhibited the RNA replication of hepatitis C virus (HCV), which be
Externí odkaz:
https://doaj.org/article/1aaa01e39e214450a7e4c97a3e2a8aa4
Autor:
Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai, Hidetsugu Saito
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-HCV and anticancer ef
Externí odkaz:
https://doaj.org/article/d927885653d9472a9a1f17560ba29dc0
Autor:
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Masashi Tachibana, Nobuyuki Kato, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
Publikováno v:
Molecular Therapy: Oncolytics, Vol 7, Iss , Pp 76-85 (2017)
Telomerase-specific replication-competent adenoviruses (Ads), i.e., TRADs, which possess an E1 gene expression cassette driven by the human telomerase reverse transcriptase promoter, are promising agents for cancer treatment. However, even though onc
Externí odkaz:
https://doaj.org/article/032768b245ea4985936e8bc06c45a776
Publikováno v:
International Journal of Biomathematics. 16
A nonlinear optimal control problem in the Lotka–McKendrick population model is studied. It describes rational management of age-structured farmed populations in aquaculture and indoor farms. Employing generalized functions, we prove the impulse na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d94991453251bbde33d1b5fbfc1a9d
https://doi.org/10.1142/s1793524522501285
https://doi.org/10.1142/s1793524522501285
Publikováno v:
Applicable Analysis. 102:1281-1293
We consider a nonlinear profit maximization problem in the Lotka–McKendrick model of age-structured harvested population describing farmed populations in agriculture and aquaculture. The control fu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf2c552282ecd56f957934393b1c4c9
https://doi.org/10.1080/00036811.2021.1981876
https://doi.org/10.1080/00036811.2021.1981876
Autor:
Nobuyuki Kato
Publikováno v:
Okayama Igakkai Zasshi (Journal of Okayama Medical Association). 132:131-143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e68f7ec2d5a27a8f412019473b7b96
https://doi.org/10.4044/joma.132.131
https://doi.org/10.4044/joma.132.131
Autor:
Torahiko Tanaka, Kazumichi Kuroda, Masanori Ikeda, Takaji Wakita, Nobuyuki Kato, Makoto Makishima
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 4, Pp 881-892 (2013)
Lipid droplets (LD) are dynamic storage organelles that are involved in lipid homeostasis. Hepatitis C virus (HCV) is closely associated with LDs. HCV Core and nonstructural (NS) proteins colocalize with LDs and presumably are involved in virion form
Externí odkaz:
https://doaj.org/article/a8d9dfd25e3f42a5b9e9a510bbe56305
Autor:
Aiko Fukuma, Shuetsu Fukushi, Tomoki Yoshikawa, Hideki Tani, Satoshi Taniguchi, Takeshi Kurosu, Kazutaka Egawa, Yuto Suda, Harpal Singh, Taro Nomachi, Mutsuyo Gokuden, Katsuyuki Ando, Kouji Kida, Miki Kan, Nobuyuki Kato, Akira Yoshikawa, Hiroaki Kitamoto, Yuko Sato, Tadaki Suzuki, Hideki Hasegawa, Shigeru Morikawa, Masayuki Shimojima, Masayuki Saijo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004595 (2016)
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease with a high case fatality rate, and is caused by the SFTS virus (SFTSV). SFTS is endemic to China, South Korea, and Japan. The viral RNA level in sera of patients w
Externí odkaz:
https://doaj.org/article/b6b0aad851e34abcb720b256ad5c3fd7